Reactome | rbm8a [cytosol]

rbm8a [cytosol]

Stable Identifier

R-XTR-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RBM8A, Q28BZ1

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
- Processing of Capped Intron-Containing Pre-mRNA (Xenopus tropicalis)
  - Transport of Mature Transcript to Cytoplasm (Xenopus tropicalis)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Xenopus tropicalis)
      - Transport of the export-competent mRNP complex through the NPC (Xenopus tropicalis)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Xenopus tropicalis)
        
        EJC [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
      - mRNP complex dissociates from cytosolic face of NPC (Xenopus tropicalis)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Xenopus tropicalis)
        
        EJC [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Xenopus tropicalis)
        
        EJC [cytosol] (Xenopus tropicalis)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Xenopus tropicalis)
        
        Magoh-Y14 complex [cytosol] (Xenopus tropicalis)
        
        rbm8a [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28BZ1

Gene Names

rbm8a

Reference Genes

BioGPS Gene:733972 rbm8a

ENSEMBL:ENSXETG00000042961

KEGG Gene (Xenopus tropicalis):733972 rbm8a

Monarch:733972 rbm8a

NCBI Gene:733972 rbm8a

Reference Transcript

RefSeq:NM_001045682.1 rbm8a

Other Identifiers

733972

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0006396

GO:0006397

GO:0006417

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0051028

GO:0071006

Participates

as a component of

Magoh-Y14 complex [cytosol] (Xenopus tropicalis)

Other forms of this molecule

rbm8a [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001039147.1

Xenbase

XB-GENE-6250837

Ensembl

ENSXETT00000120727, ENSXETP00000111743, ENSXETG00000042961

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