Reactome | PTPN11 [cytosol]

PTPN11 [cytosol]

Stable Identifier

R-XTR-162563

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

A0A6I8Q7T1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:A0A6I8Q7T1

Reference Genes

ENSEMBL:ENSXETG00000004305

Reference Transcript

RefSeq:XM_018093512.1

Other Identifiers

549586

GO:0004721

GO:0004725

GO:0005622

GO:0005737

GO:0006470

GO:0016311

GO:0016787

GO:0016791

GO:0036211

GO:0140096

Participates

as an input of

IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)
GAB1 binds PTPN11 (Xenopus tropicalis)
SHP2 interacts with p-KIT (Xenopus tropicalis)
Interaction of PECAM-1 and SHP-2 (Xenopus tropicalis)
Interaction of Tie2 and Shp2 (Xenopus tropicalis)
SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)
PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)
SHP2 binds to the active receptor (Xenopus tropicalis)
Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)
Activated FGFR3:p-FRS bind to PPTN11 (Xenopus tropicalis)

as a component of

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Xenopus tropicalis)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
PECAM-1:SHP-2 complex [plasma membrane] (Xenopus tropicalis)
pTie2 and SHP2 complex [plasma membrane] (Xenopus tropicalis)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Xenopus tropicalis)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Xenopus tropicalis)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Xenopus tropicalis)

as a member of

PTPN6,PTPN11 [cytosol] (Xenopus tropicalis)

This entity regulates

Negatively

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Xenopus tropicalis)

Other forms of this molecule

PTPN11 [nucleoplasm]

phospho-p-Y546,Y584-PTPN11 [cytosol]

Inferred From

PTPN11 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017949001.1

Ensembl

ENSXETP00000065524, ENSXETG00000004305, ENSXETT00000077449