Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ywhae [cytosol]
Stable Identifier
R-XTR-194368
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
YWHAE, Q66IF5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
M Phase (Xenopus tropicalis)
Mitotic Prometaphase (Xenopus tropicalis)
Recruitment of NuMA to mitotic centrosomes (Xenopus tropicalis)
Association of NuMA with microtubules (Xenopus tropicalis)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Xenopus tropicalis)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Xenopus tropicalis)
Mature centrosome:nucleated microtubules [cytosol] (Xenopus tropicalis)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Translocation of NuMA to the centrosomes (Xenopus tropicalis)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Xenopus tropicalis)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Mitotic G2-G2/M phases (Xenopus tropicalis)
G2/M Transition (Xenopus tropicalis)
AURKA Activation by TPX2 (Xenopus tropicalis)
TPX2 binds AURKA at centrosomes (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome maturation (Xenopus tropicalis)
Loss of proteins required for interphase microtubule organization from the centrosome (Xenopus tropicalis)
Loss of Nlp from mitotic centrosomes (Xenopus tropicalis)
Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)
Nlp-depleted centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome containing phosphorylated Nlp [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome containing phosphorylated Nlp [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Recruitment of mitotic centrosome proteins and complexes (Xenopus tropicalis)
Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)
Centrosomes containing recruited CDK11p58 [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Recruitment of Plk1 to centrosomes (Xenopus tropicalis)
Centrosome associated Plk1 [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Regulation of PLK1 Activity at G2/M Transition (Xenopus tropicalis)
AJUBA binds centrosome-associated AURKA (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:AURKA:AJUBA [cytosol] (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)
Centrosome:AURKA:AJUBA [cytosol] (Xenopus tropicalis)
Centrosome:AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
AURKA phosphorylates PLK1 (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
BORA binds PLK1 and AURKA (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Xenopus tropicalis)
Centrosome:p-T288-AURKA [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
TP53 Regulates Metabolic Genes (Xenopus tropicalis)
DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
DDIT4:14-3-3 dimer [cytosol] (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
DDIT4:14-3-3 dimer [cytosol] (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Organelle biogenesis and maintenance (Xenopus tropicalis)
Cilium Assembly (Xenopus tropicalis)
Anchoring of the basal body to the plasma membrane (Xenopus tropicalis)
C2CD3 binds the mother centriole (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)
basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
basal body [cytosol] (Xenopus tropicalis)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
basal body [cytosol] (Xenopus tropicalis)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)
basal body [cytosol] (Xenopus tropicalis)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Xenopus tropicalis)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
basal body [cytosol] (Xenopus tropicalis)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Programmed Cell Death (Xenopus tropicalis)
Apoptosis (Xenopus tropicalis)
Intrinsic Pathway for Apoptosis (Xenopus tropicalis)
Activation of BH3-only proteins (Xenopus tropicalis)
Activation of BAD and translocation to mitochondria (Xenopus tropicalis)
Activation of BAD by calcineurin (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Sequestration of BAD protein by 14-3-3 (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Xenopus tropicalis)
14-3-3 dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by Hippo (Xenopus tropicalis)
YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
p-WWTR1:YWHAE [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
Vesicle-mediated transport (Xenopus tropicalis)
Membrane Trafficking (Xenopus tropicalis)
Rab regulation of trafficking (Xenopus tropicalis)
RAB GEFs exchange GTP for GDP on RABs (Xenopus tropicalis)
DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)
RAB35 GEFs [cytosol] (Xenopus tropicalis)
p-2S-DENND1A,B:YWHAE dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
p-2S-DENND1A,B:YWHAE dimer [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
ywhae [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q66IF5
Gene Names
ywhae
Reference Genes
BioGPS Gene:493518 ywhae
ENSEMBL:ENSXETG00000022893
KEGG:xtr:493518 ywhae
Monarch:493518 ywhae
NCBI Gene:493518 ywhae
UCSC:Q66IF5 ywhae
Reference Transcript
RefSeq:NM_001008155.1 ywhae
Other Identifiers
493518
GO:0003824
GO:0004497
GO:0016491
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
mother centriole [cytosol] (Xenopus tropicalis)
Nlp-depleted centrosome [cytosol] (Xenopus tropicalis)
centrosome containing phosphorylated Nlp [cytosol] (Xenopus tropicalis)
cNAP-1 depleted centrosome [cytosol] (Xenopus tropicalis)
YWHAE dimer [cytosol] (Xenopus tropicalis)
centrosome [cytosol] (Xenopus tropicalis)
Inferred From
YWHAE [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001008156.1
ENSEMBL
ENSXETP00000074359
,
ENSXETT00000078196
Xenbase
XB-GENE-996375
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
