Reactome | MAPK1 [nucleoplasm]

MAPK1 [nucleoplasm]

Stable Identifier

R-XTR-199960

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

Q28H11

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-17 signaling (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - Toll-like Receptor Cascades (Xenopus tropicalis)
    - Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
      - Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
      - Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
      - MyD88-independent TLR4 cascade (Xenopus tropicalis)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)
        
        MAPK1 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28H11

Reference Genes

BioGPS Gene:549881

ENSEMBL:ENSXETG00000018576

KEGG Gene (Xenopus tropicalis):549881

Monarch:549881

NCBI Gene:549881

Reference Transcript

RefSeq:NM_001017127.2

Other Identifiers

549881

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005524

GO:0005737

GO:0005856

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0033043

GO:0043226

GO:0051716

GO:0140096

Participates

as a member of

MAPK monomers and dimers [nucleoplasm] (Xenopus tropicalis)

as a component of

MAPK1 dimer [nucleoplasm] (Xenopus tropicalis)

Other forms of this molecule

MAPK1 [azurophil granule lumen]

MAPK1 [extracellular region]

MAPK1 [ficolin-1-rich granule lumen]

MAPK1 [cytosol]

phospho-p-T185,Y187-MAPK1 [cytosol]

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

Inferred From

MAPK1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001017127.1

Ensembl

ENSXETG00000018576, ENSXETP00000079571, ENSXETT00000073723

Xenbase

XB-GENE-479467

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