Reactome | plcg1 [cytosol]

plcg1 [cytosol]

Stable Identifier

R-XTR-202320

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

PLCG1, F6Z8A1

Locations in the PathwayBrowser

Expand all

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - TCR signaling (Xenopus tropicalis)
    - Generation of second messenger molecules (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma1 (Xenopus tropicalis)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - DAP12 interactions (Xenopus tropicalis)
    - DAP12 signaling (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
      - Autophosphorylation of BTK/ITK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Autophosphorylation of PAK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation and activation of VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        PLC gamma1,2 [cytosol] (Xenopus tropicalis)
        
        plcg1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6Z8A1

Gene Names

plcg1

Reference Genes

BioGPS Gene:100496674 plcg1

ENSEMBL:ENSXETG00000019423

KEGG:xtr:100496674 plcg1

Monarch:100496674 plcg1

NCBI Gene:100496674 plcg1

UCSC:F6Z8A1 plcg1

Reference Transcript

Other Identifiers

100496674

GO:0001726

GO:0004435

GO:0005509

GO:0005737

GO:0006629

GO:0007165

GO:0008081

GO:0009395

GO:0010634

GO:0016042

GO:0016787

GO:0030027

GO:0032587

GO:0035556

GO:0042995

GO:0046488

GO:0046872

GO:0048015

GO:0051209

GO:0055085

Participates

as a component of

as an input of

as a member of

PLC gamma1,2 [cytosol] (Xenopus tropicalis)

Other forms of this molecule

phospho-plcg1 [cytosol]

plcg1 [plasma membrane]

phospho-plcg1 [plasma membrane]

Inferred From

PLCG1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017953385.2, XP_017953384.2, XP_012808222.3

ENSEMBL

ENSXETT00000068525, ENSXETG00000019423, ENSXETP00000042118, ENSXETP00000091697, ENSXETT00000042118

Xenbase

XB-GENE-982496

Cite Us!