Reactome | dusp4 [nucleoplasm]

dusp4 [nucleoplasm]

Stable Identifier

R-XTR-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

DUSP4, Q28F83

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-17 signaling (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - Toll-like Receptor Cascades (Xenopus tropicalis)
    - Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
      - Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
      - Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
      - MyD88-independent TLR4 cascade (Xenopus tropicalis)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERKs are inactivated (Xenopus tropicalis)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
        
        ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)
        
        dusp4 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28F83

Gene Names

dusp4

Reference Genes

BioGPS Gene:548863 dusp4

ENSEMBL:ENSXETG00000008156

KEGG Gene (Xenopus tropicalis):548863 dusp4

Monarch:548863 dusp4

NCBI Gene:548863 dusp4

Reference Transcript

RefSeq:NM_001016109.2 dusp4

Other Identifiers

548863

GO:0001706

GO:0001714

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005634

GO:0008138

GO:0016311

GO:0016787

GO:0017017

GO:0017018

GO:0023052

GO:0030154

GO:0040037

GO:0043226

GO:0048856

GO:0070373

GO:0140096

GO:1903225

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Xenopus tropicalis)

as a member of

ERK-specific DUSP [nucleoplasm] (Xenopus tropicalis)

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001016109.1

Xenbase

XB-GENE-1007215

Ensembl

ENSXETG00000008156, ENSXETT00000017889, ENSXETP00000017889

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