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phospho-smad2 [cytosol]
Stable Identifier
R-XTR-3009186
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
p-S465,S467-SMAD2, F7AQA6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Xenopus tropicalis)
Signaling by NODAL (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by Activin (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Signaling by TGF-beta Receptor Complex (Xenopus tropicalis)
TGF-beta receptor signaling activates SMADs (Xenopus tropicalis)
Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Downregulation of TGF-beta receptor signaling (Xenopus tropicalis)
MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
phospho-smad2 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F7AQA6
Gene Names
smad2
Reference Genes
BioGPS Gene:496586 smad2
ENSEMBL:ENSXETG00000020292
Monarch:496586 smad2
NCBI Gene:496586 smad2
UCSC:F7AQA6 smad2
Reference Transcript
RefSeq:XM_031899046.1 smad2
RefSeq:XM_018092817.1 smad2
RefSeq:XM_012960839.2 smad2
RefSeq:XM_012960846.2 smad2
RefSeq:XM_031899043.1 smad2
RefSeq:XM_018092812.1 smad2
Other Identifiers
496586
GO:0000978
GO:0000981
GO:0001228
GO:0001702
GO:0003002
GO:0003677
GO:0003690
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006355
GO:0007179
GO:0007369
GO:0007498
GO:0009653
GO:0009880
GO:0010172
GO:0010629
GO:0030154
GO:0032924
GO:0032991
GO:0042802
GO:0045944
GO:0046332
GO:0046872
GO:0048856
GO:0051239
GO:0060395
GO:0060485
GO:0070411
GO:0071144
GO:0071363
GO:0140297
GO:0141091
Participates
as an input of
PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)
MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)
as a component of
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Xenopus tropicalis)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Xenopus tropicalis)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Xenopus tropicalis)
as an output of
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)
Other forms of this molecule
smad2 [cytosol]
phospho-smad2 [cytosol]
smad2 [nucleoplasm]
phospho-smad2 [nucleoplasm]
phospho-smad2 [nucleoplasm]
smad2 [cytosol]
phospho-smad2 [nucleoplasm]
Inferred From
p-2S-SMAD2,3 [cytosol]
(Homo sapiens)
p-S465,S467-SMAD2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 465 (in Homo sapiens)
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467 (in Homo sapiens)
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_031754903.1
,
XP_017948301.1
,
XP_012816293.1
,
XP_012816300.1
,
XP_017948306.1
,
XP_031754906.1
ENSEMBL
ENSXETT00000043789
,
ENSXETP00000043789
,
ENSXETG00000020292
Xenbase
XB-GENE-482930
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