Reactome | LYN [cytosol]

LYN [cytosol]

Stable Identifier

R-XTR-354251

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

Q28IV0

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        EPHA binds TIAM1 (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPHA-mediated growth cone collapse (Xenopus tropicalis)
        
        NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPHB-mediated forward signaling (Xenopus tropicalis)
        
        EPHB phosphorylates TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)

Hemostasis (Xenopus tropicalis)

- Cell surface interactions at the vascular wall (Xenopus tropicalis)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
      - LYN [cytosol] (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
- Platelet Adhesion to exposed collagen (Xenopus tropicalis)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
      - LYN [cytosol] (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
  - GPVI binds Fyn and Lyn (Xenopus tropicalis)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
      - LYN [cytosol] (Xenopus tropicalis)
    - LYN [cytosol] (Xenopus tropicalis)
- Platelet activation, signaling and aggregation (Xenopus tropicalis)
  - GPVI-mediated activation cascade (Xenopus tropicalis)
    - Binding of Syk tyrosine kinase (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - SYK autophosphorylates (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - p-Y348-SYK dissociates (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Xenopus tropicalis)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Regulation of T cell activation by CD28 family (Xenopus tropicalis)
    - Co-inhibition by CTLA4 (Xenopus tropicalis)
      - SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Co-stimulation by CD28 (Xenopus tropicalis)
      - Phosphorylation of CD28 (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Xenopus tropicalis)
      - Regulation of signaling by CBL (Xenopus tropicalis)
        
        CBL ubiquitinates PI3K (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - C-type lectin receptors (CLRs) (Xenopus tropicalis)
    - CD209 (DC-SIGN) signaling (Xenopus tropicalis)
      - SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)
        
        FYN, LYN [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Erythropoietin (Xenopus tropicalis)
  - EPOR binds EPOR agonists (Xenopus tropicalis)
    - EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
      - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
      - LYN [cytosol] (Xenopus tropicalis)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Xenopus tropicalis)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
      - PI3K bound to EPOR [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
  - Erythropoietin activates RAS (Xenopus tropicalis)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Xenopus tropicalis)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by SCF-KIT (Xenopus tropicalis)
    - Dimerization of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - JAK2 binds to p-KIT (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation and activation of VAV1 (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of JAK2 (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Recruitment of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Regulation of KIT signaling (Xenopus tropicalis)
      - Interaction of APS and p-KIT (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - Phosphorylation of APS (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - SHP2 interacts with p-KIT (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)
    - Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        LYN [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28IV0

Reference Genes

BioGPS Gene:549989

ENSEMBL:ENSXETG00000005650

KEGG:xtr:549989

Monarch:549989

NCBI Gene:549989

UCSC:Q28IV0

Reference Transcript

RefSeq:NM_001017235.2

Participates

as a candidate of

FYN-like kinases [cytosol] (Xenopus tropicalis)

as a component of

as a member of

as an input of

GPVI binds Fyn and Lyn (Xenopus tropicalis)

Other forms of this molecule

MyrG2-PalmC3-LYN [lysosomal membrane]

MyrG2-PalmC3-LYN [endocytic vesicle membrane]

LYN [plasma membrane]

phospho-p-Y397-LYN [cytosol]

phospho-p-Y397-LYN [plasma membrane]

MyrG2-PalmC3-LYN [plasma membrane]

Inferred From

LYN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001017235.1

Xenbase

XB-GENE-1015126

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