Reactome | nsl1 [cytosol]

nsl1 [cytosol]

Stable Identifier

R-XTR-375309

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

NSL1, A0A6I8Q2C1

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - Mitotic Spindle Checkpoint (Xenopus tropicalis)
    - Amplification of signal from the kinetochores (Xenopus tropicalis)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Xenopus tropicalis)
        
        MAD2 associates with the Mad1 kinetochore complex (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Mad1 binds kinetochore (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Release of activated MAD2 from kinetochores (Xenopus tropicalis)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Mad1:kinetochore complex [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
- Cell Cycle, Mitotic (Xenopus tropicalis)
  - M Phase (Xenopus tropicalis)
    - Mitotic Metaphase and Anaphase (Xenopus tropicalis)
      - Mitotic Anaphase (Xenopus tropicalis)
        
        Separation of Sister Chromatids (Xenopus tropicalis)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Xenopus tropicalis)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
    - Mitotic Prometaphase (Xenopus tropicalis)
      - EML4 and NUDC in mitotic spindle formation (Xenopus tropicalis)
        
        EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
      - Kinetochore capture of astral microtubules (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
      - Resolution of Sister Chromatid Cohesion (Xenopus tropicalis)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Kinetochore assembly (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase Effectors (Xenopus tropicalis)
      - RHO GTPases Activate Formins (Xenopus tropicalis)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)
        
        Microtubule-bound kinetochore [cytosol] (Xenopus tropicalis)
        
        Kinetochore [cytosol] (Xenopus tropicalis)
        
        KMN network [cytosol] (Xenopus tropicalis)
        
        Mis12 complex [cytosol] (Xenopus tropicalis)
        
        nsl1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8Q2C1

Gene Names

nsl1

Reference Genes

ENSEMBL:ENSXETG00000030886

KEGG Gene (Xenopus tropicalis):100380008 nsl1

Reference Transcript

RefSeq:XM_002934685.5 nsl1

Other Identifiers

100380008

GO:0000070

GO:0000278

GO:0000776

GO:0005694

GO:0007059

GO:0043226

GO:0140014

Participates

as a component of

Mis12 complex [cytosol] (Xenopus tropicalis)

Inferred From

NSL1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002934731.3

Xenbase

XB-GENE-952201

Ensembl

ENSXETT00000092603, ENSXETP00000066720, ENSXETG00000030886

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