Reactome | tcp10l2 [cytosol]

tcp10l2 [cytosol]

Stable Identifier

R-XTR-380291

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

CENPJ, A0A803JNS2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - TP53 Regulates Transcription of Cell Cycle Genes (Xenopus tropicalis)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Xenopus tropicalis)
        
        PLK2 phosphorylates CENPJ (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)

Organelle biogenesis and maintenance (Xenopus tropicalis)

- Cilium Assembly (Xenopus tropicalis)
  - Anchoring of the basal body to the plasma membrane (Xenopus tropicalis)
    - C2CD3 binds the mother centriole (Xenopus tropicalis)
      - mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)
      - basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
        
        basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)
      - basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - MARK4 binds ODF2 in the centriole (Xenopus tropicalis)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Xenopus tropicalis)
        
        basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - Recruitment of transition zone proteins (Xenopus tropicalis)
      - basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - basal body:transition zone proteins [cytosol] (Xenopus tropicalis)
        
        basal body [cytosol] (Xenopus tropicalis)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
    - The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Xenopus tropicalis)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Xenopus tropicalis)
        
        mother centriole:C2CD3 [cytosol] (Xenopus tropicalis)
        
        mother centriole [cytosol] (Xenopus tropicalis)
        
        tcp10l2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A803JNS2

Gene Names

tcp10l2

Reference Genes

ENSEMBL:ENSXETG00000042751

KEGG Gene (Xenopus tropicalis):100493055 tcp10l2

Reference Transcript

RefSeq:XM_012963719.3 tcp10l2

Other Identifiers

100493055

GO:0005814

GO:0005815

GO:0005856

GO:0007010

GO:0008092

GO:0015631

GO:0043226

GO:0046599

GO:0051301

Participates

as a component of

as an input of

PLK2 phosphorylates CENPJ (Xenopus tropicalis)

Other forms of this molecule

phospho-tcp10l2 [cytosol]

Inferred From

CENPJ [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012819173.2

Ensembl

ENSXETG00000042751, ENSXETT00000118561, ENSXETP00000109614

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