Reactome | tab2 [endosome membrane]

tab2 [endosome membrane]

Stable Identifier

R-XTR-450279

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

endosome membrane

Synonyms

TAB2, F6YEZ3

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Innate Immune System (Xenopus tropicalis)
  - Toll-like Receptor Cascades (Xenopus tropicalis)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Xenopus tropicalis)
        
        Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Xenopus tropicalis)
        
        TAK1 complex [endosome membrane] (Xenopus tropicalis)
        
        TAB2/3 [endosome membrane] (Xenopus tropicalis)
        
        tab2 [endosome membrane] (Xenopus tropicalis)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Xenopus tropicalis)
        
        TAB2/3 [endosome membrane] (Xenopus tropicalis)
        
        tab2 [endosome membrane] (Xenopus tropicalis)
    - Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Xenopus tropicalis)
        
        Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Xenopus tropicalis)
        
        TAK1 complex [endosome membrane] (Xenopus tropicalis)
        
        TAB2/3 [endosome membrane] (Xenopus tropicalis)
        
        tab2 [endosome membrane] (Xenopus tropicalis)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Xenopus tropicalis)
        
        TAB2/3 [endosome membrane] (Xenopus tropicalis)
        
        tab2 [endosome membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6YEZ3

Gene Names

tab2

Reference Genes

BioGPS Gene:100037849 tab2

ENSEMBL:ENSXETG00000021389

KEGG:xtr:100037849 tab2

Monarch:100037849 tab2

NCBI Gene:100037849 tab2

UCSC:F6YEZ3 tab2

Reference Transcript

Other Identifiers

100037849

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005829

GO:0007507

GO:0008270

GO:0010008

GO:0016020

GO:0016301

GO:0043123

GO:0043130

GO:0046872

GO:0048856

GO:0070530

Participates

as a member of

TAB2/3 [endosome membrane] (Xenopus tropicalis)

Other forms of this molecule

tab2 [plasma membrane]

tab2 [cytosol]

Inferred From

TAB2 [endosome membrane] (Homo sapiens)

Cross References

RefSeq

XP_012817985.1, NP_001090763.1, XP_017949214.1, XP_017949215.1, XP_017949216.1, XP_017949217.1

ENSEMBL

ENSXETG00000021389, ENSXETT00000046262, ENSXETP00000046262

Xenbase

XB-GENE-975095

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