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phospho-nfkb1 [cytosol]
Stable Identifier
R-XTR-451619
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
3xUb-p-S927,S932-NFKB1(1-968), F6T195
Locations in the PathwayBrowser
Expand all
Immune System (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
Signaling by Interleukins (Xenopus tropicalis)
Interleukin-1 family signaling (Xenopus tropicalis)
Interleukin-1 signaling (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Interleukin-17 signaling (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Toll-like Receptor Cascades (Xenopus tropicalis)
Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
MyD88-independent TLR4 cascade (Xenopus tropicalis)
TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
MAP kinase activation (Xenopus tropicalis)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Xenopus tropicalis)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
phospho-nfkb1 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F6T195
Gene Names
nfkb1
Reference Genes
ENSEMBL:ENSXETG00000021325 nfkb1
ENSEMBL:ENSXETG00000041752
KEGG Gene (Xenopus tropicalis):100486083 nfkb1
Reference Transcript
RefSeq:XM_002934759.4 nfkb1
Other Identifiers
100486083
GO:0003677
GO:0003700
GO:0005634
GO:0005737
GO:0006351
GO:0006355
GO:0007165
GO:0023052
GO:0043226
GO:0140110
Participates
as a component of
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Xenopus tropicalis)
This entity regulates
Negatively
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
(Xenopus tropicalis)
Other forms of this molecule
nfkb1 [specific granule lumen]
nfkb1 [extracellular region]
nfkb1 [secretory granule lumen]
nfkb1 [cytosol]
nfkb1 [nucleoplasm]
nfkb1 [cytosol]
phospho-nfkb1 [cytosol]
Inferred From
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 927 (in Homo sapiens)
Coordinate
927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 932 (in Homo sapiens)
Coordinate
932
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_002934805.3
Xenbase
XB-GENE-985746
Ensembl
ENSXETG00000021325
,
ENSXETP00000046127
,
ENSXETT00000046127
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