Reactome | phospho-p-Y-JAK1 [cytosol]

phospho-p-Y-JAK1 [cytosol]

Stable Identifier

R-XTR-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

F7DKS0

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by CSF3 (G-CSF) (Xenopus tropicalis)
    - Inactivation of CSF3 (G-CSF) signaling (Xenopus tropicalis)
      - CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Xenopus tropicalis)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-10 signaling (Xenopus tropicalis)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y-JAK1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7DKS0

Reference Genes

BioGPS Gene:100038172

ENSEMBL:ENSXETG00000020396

KEGG:xtr:100038172

Monarch:100038172

NCBI Gene:100038172

UCSC:F7DKS0

Reference Transcript

RefSeq:XM_002931596.5

Other Identifiers

100038172

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005524

GO:0005737

GO:0005829

GO:0005856

GO:0007165

GO:0007259

GO:0012505

GO:0016020

GO:0016301

GO:0016740

GO:0019221

GO:0030154

GO:0035556

GO:0046872

GO:0060397

GO:0098761

GO:0140096

Participates

as a component of

Other forms of this molecule

phospho-p-Y1034,Y1035-JAK1 [cytosol]

phospho-p-JAK1 [cytosol]

phospho-p-Y1034-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSXETT00000044013, ENSXETG00000020396, ENSXETP00000044013

Xenbase

XB-GENE-483750

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