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xpa [nucleoplasm]
Stable Identifier
R-XTR-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
nucleoplasm
Synonyms
XPA, A0A803KI50
Locations in the PathwayBrowser
Expand all
DNA Repair (Xenopus tropicalis)
Nucleotide Excision Repair (Xenopus tropicalis)
Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
Dual Incision in GG-NER (Xenopus tropicalis)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Xenopus tropicalis)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Xenopus tropicalis)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Formation of Incision Complex in GG-NER (Xenopus tropicalis)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Recruitment of XPA and release of CAK (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
Dual incision in TC-NER (Xenopus tropicalis)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)
TC-NER incision complex [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Formation of TC-NER Pre-Incision Complex (Xenopus tropicalis)
UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)
TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Xenopus tropicalis)
xpa [nucleoplasm] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A803KI50
Gene Names
xpa
Reference Genes
BioGPS Gene:549490 xpa
ENSEMBL:ENSXETG00000010181
KEGG:xtr:549490 xpa
Monarch:549490 xpa
NCBI Gene:549490 xpa
UCSC:A0A803KI50 xpa
Reference Transcript
RefSeq:NM_001016736.2 xpa
Participates
as a component of
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex [nucleoplasm] (Xenopus tropicalis)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Xenopus tropicalis)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Xenopus tropicalis)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Xenopus tropicalis)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Xenopus tropicalis)
as an input of
Recruitment of XPA and release of CAK (Xenopus tropicalis)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
Xenbase
XB-GENE-977981
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