Reactome | RPA heterotrimer [nucleoplasm]

RPA heterotrimer [nucleoplasm]

Stable Identifier

R-XTR-68462

Type

Complex

Species

Xenopus tropicalis

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - Regulation of TP53 Activity (Xenopus tropicalis)
        
        Regulation of TP53 Activity through Phosphorylation (Xenopus tropicalis)
        
        ATR phosphorylates TP53 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Xenopus tropicalis)
        
        RPA heterotrimer [nucleoplasm] (Xenopus tropicalis)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

as an input of

Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)

as an output of

PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)

Inferred From

RPA heterotrimer [nucleoplasm] (Homo sapiens)

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