Reactome | Ghost homologue of SHC1 [cytosol]

Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - RET signaling (Xenopus tropicalis)
      - SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)

Hemostasis (Xenopus tropicalis)

- Platelet activation, signaling and aggregation (Xenopus tropicalis)
  - Platelet Aggregation (Plug Formation) (Xenopus tropicalis)
    - Integrin signaling (Xenopus tropicalis)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Integrin signaling (Xenopus tropicalis)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Xenopus tropicalis)
      - Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)
- Signaling by Nuclear Receptors (Xenopus tropicalis)
  - ESR-mediated signaling (Xenopus tropicalis)
    - Extra-nuclear estrogen signaling (Xenopus tropicalis)
      - MMPs cleave HB-EGF (Xenopus tropicalis)
        
        ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by EGFR (Xenopus tropicalis)
    - SHC1 events in EGFR signaling (Xenopus tropicalis)
      - SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)
  - Signaling by ERBB2 (Xenopus tropicalis)
    - SHC1 events in ERBB2 signaling (Xenopus tropicalis)
      - SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)
  - Signaling by ERBB4 (Xenopus tropicalis)
    - SHC1 events in ERBB4 signaling (Xenopus tropicalis)
      - Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)
        
        SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)
  - Signaling by Insulin receptor (Xenopus tropicalis)
    - Insulin receptor signalling cascade (Xenopus tropicalis)
      - Phosphorylation of SHC1 (Xenopus tropicalis)
        
        Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Xenopus tropicalis)
        
        Ghost homologue of SHC1 [cytosol] (Xenopus tropicalis)