Reactome | klhl2 [cytosol]

klhl2 [cytosol]

Stable Identifier

R-XTR-8863217

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

KLHL2, A0A6I8RN17

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8RN17

Gene Names

klhl2

Reference Genes

BioGPS Gene:100495582 klhl2

ENSEMBL:ENSXETG00000034185

Monarch:100495582 klhl2

NCBI Gene:100495582 klhl2

UCSC:A0A6I8RN17 klhl2

Reference Transcript

RefSeq:XM_012955640.3 klhl2

Other Identifiers

100495582

Participates

as a member of

BTB proteins [cytosol] (Xenopus tropicalis)

Inferred From

KLHL2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012811094.1

ENSEMBL

ENSXETP00000086228, ENSXETT00000090039

Xenbase

XB-GENE-494633

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