Reactome | klhl41 [cytosol]

klhl41 [cytosol]

Stable Identifier

R-XTR-8863222

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

KLHL41, Q6P4N4

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl41 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6P4N4

Gene Names

klhl41

Reference Genes

BioGPS Gene:394822 klhl41

ENSEMBL:ENSXETG00000018861

KEGG:xtr:394822 klhl41

Monarch:394822 klhl41

NCBI Gene:394822 klhl41

UCSC:Q6P4N4 klhl41

Reference Transcript

RefSeq:NM_203883.1 klhl41

Participates

as a member of

BTB proteins [cytosol] (Xenopus tropicalis)

Inferred From

KLHL41 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_989214.1

Xenbase

XB-GENE-5850464

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