Reactome | phospho-erbb2 [plasma membrane]

phospho-erbb2 [plasma membrane]

Stable Identifier

R-XTR-8864084

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

p-Y1023,Y1139,Y1221,Y1222-ERBB2, A0A6I8S7Y3

Locations in the PathwayBrowser

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Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by ERBB2 (Xenopus tropicalis)
    - Downregulation of ERBB2 signaling (Xenopus tropicalis)
      - PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18 [plasma membrane] (Xenopus tropicalis)
        
        Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] (Xenopus tropicalis)
        
        EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Xenopus tropicalis)
        
        phospho-erbb2 [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8S7Y3

Gene Names

erbb2

Reference Genes

BioGPS Gene:100492078 erbb2

ENSEMBL:ENSXETG00000015145

KEGG Gene (Xenopus tropicalis):100492078 erbb2

Monarch:100492078 erbb2

NCBI Gene:100492078 erbb2

Reference Transcript

RefSeq:XM_002940374.4 erbb2

Participates

as a component of

EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Xenopus tropicalis)

Other forms of this molecule

phospho-erbb2 [plasma membrane]

erbb2 [plasma membrane]

phospho-erbb2 [plasma membrane]

Inferred From

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1023 (in Homo sapiens)

Coordinate

1023

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1139 (in Homo sapiens)

Coordinate

1139

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1221 (in Homo sapiens)

Coordinate

1221

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1222 (in Homo sapiens)

Coordinate

1222

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_002940420.2

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