Reactome | klhl13 [cytosol]

klhl13 [cytosol]

Stable Identifier

R-XTR-976041

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

KLHL13, F7BS33

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        RBX1:CUL3:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Xenopus tropicalis)
        
        BTB proteins [cytosol] (Xenopus tropicalis)
        
        klhl13 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7BS33

Gene Names

klhl13

Reference Genes

BioGPS Gene:493457 klhl13

ENSEMBL:ENSXETG00000003672

Monarch:493457 klhl13

NCBI Gene:493457 klhl13

UCSC:F7BS33 klhl13

Reference Transcript

Other Identifiers

493457

GO:0003824

GO:0004842

GO:0005829

GO:0016567

GO:0016740

GO:0031463

GO:0032465

GO:0051301

GO:0097602

GO:0140096

Participates

as a member of

BTB proteins [cytosol] (Xenopus tropicalis)

Other forms of this molecule

klhl13 [cytosol]

Inferred From

KLHL13 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_031746247.1, XP_012823725.1

ENSEMBL

ENSXETT00000007921, ENSXETG00000003672, ENSXETP00000007921

Xenbase

XB-GENE-923144

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