Reactome | UniProt:P15056 BRAF

UniProt:P15056 BRAF

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

BRAF_HUMAN, A4D1T4, B6HY61, B6HY62, B6HY63, B6HY64, B6HY65, B6HY66, Q13878, Q3MIN6, Q9UDP8, Q9Y6T3

List of interactors in Reactome

Interactors (71)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
Q02750	4	MAP2K1 [cytosol] (R-HSA-59502) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.98	65
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.968	73
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.941	15
P31946	1	YWHAB [cytosol] (R-HSA-48888)	0.932	14
P15056	3	BRAF [cytosol] (R-HSA-167224) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S446,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679)	0.927	14
P61981	1	YWHAG [cytosol] (R-HSA-380312)	0.912	12
P36507	4	MAP2K2 [cytosol] (R-HSA-59504) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) p-S,T-MAP2K2 [cytosol] (R-HSA-109848)	0.894	13
P62258	1	YWHAE [cytosol] (R-HSA-194368)	0.889	11
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.767	6
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.731	5
Q14145	1	KEAP1 [cytosol] (R-HSA-976038)	0.681	16
P01116	2	p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814)	0.68	5
Q13233	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.609	2
O00255	2	MEN1 [cytosol] (R-HSA-5672315) MEN1 [nucleoplasm] (R-HSA-2186626)	0.596	4
O14920	3	IKBKB [cytosol] (R-HSA-168114) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.596	5
O14965	3	AURKA [cytosol] (R-HSA-174254) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.596	5
O43524	11	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.596	5
P40337	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127)	0.596	7
P49840	2	GSK3A [cytosol] (R-HSA-198326) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.596	6
Q07817	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.596	7
Q13164	3	MAPK7 [cytosol] (R-HSA-198754) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738)	0.596	5
Q9UMX1	2	SUFU [ciliary tip] (R-HSA-5610426) SUFU [cytosol] (R-HSA-445455)	0.596	4
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.577	4
O15297	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.553	4
P04637	2	polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 [nucleoplasm] (R-HSA-69488)	0.553	4
P07196	1	NEFL [cytosol] (R-HSA-432284)	0.553	4
P16885	5	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-114601)	0.553	4
P21399	1	ACO1 [cytosol] (R-HSA-5690899)	0.553	4
P25311	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.553	3
P27986	1	PIK3R1 [cytosol] (R-HSA-74789)	0.553	3
P28715	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.553	3
P35221	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.553	4
P42772	1	CDKN2B [cytosol] (R-HSA-182586)	0.553	4
P49407	1	ARRB1 [cytosol] (R-HSA-264470)	0.553	4
P61024	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.553	4
P61224	1	RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.553	4
Q12967	1	RALGDS [cytosol] (R-HSA-171001)	0.553	4
Q6P1J9	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.553	4
Q92560	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.553	4
P46940	1	IQGAP1 [plasma membrane] (R-HSA-381681)	0.544	4
Q16659	6	MAPK6 [cytosol] (R-HSA-5686979) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.539	3
P11021	4	HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [plasma membrane] (R-HSA-9922467)	0.527	3
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.527	2
Q14154	3	DELE1 [mitochondrial inner membrane] (R-HSA-9840377) DELE1(143-515) [cytosol] (R-HSA-9840380) DELE1(143-515) [mitochondrial inner membrane] (R-HSA-9840386)	0.527	2
Q9UIM3	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
Q99N57	3	phospho-Raf1 [plasma membrane] (R-MMU-5672665) phospho-Raf1 [plasma membrane] (R-MMU-5675193) Raf1 [cytosol] (R-MMU-167205)	0.499	3
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.483	3
P19367	1	HK1 [cytosol] (R-HSA-70395)	0.471	2
P21912	1	SDHB [mitochondrial matrix] (R-HSA-9854983)	0.471	2
P23458	2	JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [endoplasmic reticulum lumen] (R-HSA-9931304)	0.471	2
P28347	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.471	2
P30291	4	p-S53-WEE1 [nucleoplasm] (R-HSA-156694) p-T187,T190-WEE1 [nucleoplasm] (R-HSA-9929669) p-WEE1 [nucleoplasm] (R-HSA-156491) WEE1 [nucleoplasm] (R-HSA-69253)	0.471	2
P31040	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.471	2
P32121	1	ARRB2 [cytosol] (R-HSA-416464)	0.471	2
P52333	1	JAK3 [cytosol] (R-HSA-451893)	0.471	2
P53778	2	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021)	0.471	2
P78333	1	GPI-GPC5 [plasma membrane] (R-HSA-5362430)	0.471	2
Q00534	1	CDK6 [nucleoplasm] (R-HSA-141283)	0.471	2
Q00597	1	FANCC [nucleoplasm] (R-HSA-419530)	0.471	2
Q06187	2	Active BTK [cytosol] (R-HSA-8964323) BTK [cytosol] (R-HSA-197948)	0.471	2
Q13882	4	p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000)	0.471	2
Q15561	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.471	2
Q70Z35	1	PREX2 [cytosol] (R-HSA-8850949)	0.471	2
Q86WJ1	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.471	2
Q96AV8	1	E2F7 [nucleoplasm] (R-HSA-6798305)	0.471	2
Q9BZK7	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.471	2
Q9HB63	1	NTN4 [plasma membrane] (R-HSA-561258)	0.471	2
Q9NW38	1	FANCL [nucleoplasm] (R-HSA-419520)	0.471	2
Q9NXR7	1	BRE [nucleoplasm] (R-HSA-5682579)	0.471	2
Q9UIV8	1	SERPINB13 [lysosomal lumen] (R-HSA-8938045)	0.471	2

Cite Us!