Reactome | UniProt:P31749 AKT1

UniProt:P31749 AKT1

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

AKT1_HUMAN, B2RAM5, B7Z5R1, Q9BWB6

List of interactors in Reactome

Interactors (85)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P49841	3	GSK3B [cytosol] (R-HSA-2997551) GSK3B [endoplasmic reticulum lumen] (R-HSA-9931408) GSK3B [nucleoplasm] (R-HSA-2022823)	0.825	5
O15530	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.815	5
Q00987	7	MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.807	6
P67775	1	PPP2CA [cytosol] (R-HSA-165971)	0.756	4
O43524	11	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.753	4
Q15047	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.72	10
P46527	5	CDKN1B [cytosol] (R-HSA-198622) CDKN1B [nucleoplasm] (R-HSA-182563) p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-Y88-CDKN1B [cytosol] (R-HSA-8848438)	0.712	4
P08670	7	VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(2-429) [cytosol] (R-HSA-350317) VIM(2-85) [cytosol] (R-HSA-350264) VIM(260-466) [cytosol] (R-HSA-350314) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294)	0.706	29
P32121	1	ARRB2 [cytosol] (R-HSA-416464)	0.701	5
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.692	4
O95999	3	BCL10 [cytosol] (R-HSA-202447) K48polyUb-BCL10 [cytosol] (R-HSA-8939329) p-BCL10 [cytosol] (R-HSA-202488)	0.69	5
Q6GPH4	1	XAF1 [cytosol] (R-HSA-1015680)	0.666	4
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.653	4
P31751	1	p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056)	0.641	3
P23443	2	p-T412-RPS6KB1 [cytosol] (R-HSA-165714) RPS6KB1 [cytosol] (R-HSA-165716)	0.64	3
Q86V81	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.639	5
Q13315	4	ATM [cytosol] (R-HSA-9665171) ATM [nucleoplasm] (R-HSA-69484) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527)	0.636	5
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.623	3
Q13043	1	STK4(327-487) [cytosol] (R-HSA-2028668)	0.619	13
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.615	4
P26358	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.611	6
Q00597	1	FANCC [nucleoplasm] (R-HSA-419530)	0.609	4
Q9HB96	1	FANCE [nucleoplasm] (R-HSA-419543)	0.609	4
P19174	4	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682)	0.602	9
Q96EB6	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	5
P62324	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.596	4
Q13309	1	SKP2 [nucleoplasm] (R-HSA-975554)	0.596	4
P10276	2	polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.583	3
P15056	3	BRAF [cytosol] (R-HSA-167224) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S446,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679)	0.577	4
Q13485	4	SMAD4 [cytosol] (R-HSA-170862) SMAD4 [nucleoplasm] (R-HSA-177103) Ub-SMAD4 [cytosol] (R-HSA-9773859) Ub-SMAD4 [nucleoplasm] (R-HSA-9773863)	0.577	6
O60437	1	PPL [cytosol] (R-HSA-6810850)	0.573	2
P62136	1	PPP1CA [cytosol] (R-HSA-163525)	0.571	4
Q12778	5	Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306)	0.571	2
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.564	3
Q5S007	1	LRRK2 [cytosol] (R-HSA-5661173)	0.558	6
Q99683	1	MAP3K5 [cytosol] (R-HSA-167709)	0.558	2
P06241	3	FYN [cytosol] (R-HSA-200917) p-Y420-FYN [cytosol] (R-HSA-391821) p-Y531-FYN [cytosol] (R-HSA-391819)	0.556	3
P10599	4	2xHC-TXN [cytosol] (R-HSA-73668) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [cytosol] (R-HSA-66000) TXN [nucleoplasm] (R-HSA-9617732)	0.556	3
P17612	2	PRKACA [cytosol] (R-HSA-57844) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
P22466	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
P42858	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
P04198	1	MYCN [nucleoplasm] (R-HSA-452357)	0.553	3
P25963	4	monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA [cytosol] (R-HSA-168151) NFKBIA [nucleoplasm] (R-HSA-4656929) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677)	0.553	3
P30281	1	CCND3 [nucleoplasm] (R-HSA-113835)	0.553	3
P54646	2	PRKAA2 [cytosol] (R-HSA-200405) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.553	3
Q07820	1	MCL1 [cytosol] (R-HSA-5661490)	0.553	3
Q15910	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.553	3
Q99728	1	BARD1 [nucleoplasm] (R-HSA-5659775)	0.553	3
P05771	1	PRKCB [cytosol] (R-HSA-58198)	0.547	2
P49327	2	FASN [cytosol] (R-HSA-199233) FASN [cytosol] (R-HSA-54659)	0.547	2
Q05513	1	PRKCZ [cytosol] (R-HSA-58218)	0.544	2
Q92547	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	2
P15880	2	Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.529	3
P24468	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.527	3
P20248	2	CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.524	2
P29067	1	Arrb2 [cytosol] (R-RNO-416464)	0.524	2
O14965	3	AURKA [cytosol] (R-HSA-174254) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.519	2
P43246	1	MSH2 [nucleoplasm] (R-HSA-5357525)	0.519	2
P54278	1	PMS2 [nucleoplasm] (R-HSA-5357527)	0.519	2
Q15796	1	SMAD2 [cytosol] (R-HSA-3006353)	0.519	2
Q15831	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.519	2
Q9UKG1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.519	2
P29474	3	2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) NOS3 [cytosol] (R-HSA-202114)	0.509	3
P10636	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.499	2
Q92793	3	CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.499	3
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.483	3
P17844	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186)	0.483	3
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.483	2
O95750	1	FGF19 [extracellular region] (R-HSA-189888)	0.471	2
P01106	1	MYC [nucleoplasm] (R-HSA-188379)	0.471	2
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.471	2
P31040	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.471	2
P49815	3	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548)	0.471	2
Q15116	1	PDCD1 [plasma membrane] (R-HSA-197604)	0.471	2
Q86WJ1	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.471	2
Q92956	1	TNFRSF14 [plasma membrane] (R-HSA-198101)	0.471	2
Q96GD4	1	AURKB [nucleoplasm] (R-HSA-4655360)	0.471	2
Q9GZV9	3	FGF23(25-251) [Golgi lumen] (R-HSA-8851630) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624)	0.471	2
Q9HCE7	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.471	2
P27540	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.454	2
P63000	1	RAC1 [cytosol] (R-HSA-442615)	0.454	2
Q01094	1	E2F1 [nucleoplasm] (R-HSA-68639)	0.454	2
Q01196	3	p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) RUNX1 [nucleoplasm] (R-HSA-8865295) RUNX1 [plasma membrane] (R-HSA-5667138)	0.454	2
Q06124	2	PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745)	0.454	3

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