Reactome | UniProt:P62993 GRB2

UniProt:P62993 GRB2

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

GRB2_HUMAN, P29354, Q14450, Q63057, Q63059

List of interactors in Reactome

Interactors (90)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.982	58
P29353	2	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680)	0.974	31
Q07889	1	SOS1 [cytosol] (R-HSA-64847)	0.97	27
P22681	3	CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.961	18
Q9UQC2	1	GAB2 [cytosol] (R-HSA-508239)	0.95	15
O00401	1	N-WASP [cytosol] (R-HSA-201873)	0.928	11
P18433	1	PTPRA [plasma membrane] (R-HSA-388755)	0.921	13
O95630	1	STAMBP [cytosol] (R-HSA-5693063)	0.92	9
P50570	2	DNM2 [cytosol] (R-HSA-2213180) DNM2 [plasma membrane] (R-HSA-2984201)	0.918	9
Q13094	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.918	18
P04626	1	ERBB2 [plasma membrane] (R-HSA-372889)	0.916	8
Q13480	1	GAB1 [cytosol] (R-HSA-179795)	0.898	12
Q06124	2	PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745)	0.893	10
Q07666	3	KHDRBS1 [nucleoplasm] (R-HSA-8848941) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970)	0.868	8
P27986	1	PIK3R1 [cytosol] (R-HSA-74789)	0.863	6
P61978	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.848	10
Q9UKW4	1	p-Y173-VAV3 [cytosol] (R-HSA-442287)	0.848	8
Q05193	1	DNM1 [plasma membrane] (R-HSA-177488)	0.829	7
P35235	3	Ptpn11 [cytosol] (R-MMU-210002) PTPN11 [cytosol] (R-MMU-162563) PTPN11 [nucleoplasm] (R-MMU-8937745)	0.809	7
P10721	1	KIT [plasma membrane] (R-HSA-197662)	0.743	6
Q8WV28	1	BLNK [cytosol] (R-HSA-912750)	0.743	5
P42336	1	PIK3CA [cytosol] (R-HSA-74787)	0.742	5
P62993	1	GRB2 [cytosol] (R-HSA-8983328)	0.738	5
Q6ZUJ8	1	p-4Y-PIK3AP1 [plasma membrane] (R-HSA-984814)	0.738	5
P35570	2	Irs1 [cytosol] (R-RNO-74769) Irs1 [plasma membrane] (R-RNO-2425392)	0.737	5
P21802	1	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703)	0.735	6
O43561	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.708	7
Q62245	1	Sos1 [cytosol] (R-MMU-64847)	0.704	4
O14744	2	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.666	4
Q9Y2W2	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.666	4
P15498	2	p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [cytosol] (R-HSA-195066)	0.665	3
P98078	2	Dab2 [cytosol] (R-MMU-8862456) Dab2 [plasma membrane] (R-MMU-2980808)	0.662	4
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.659	4
P35579	1	MYH9 [cytosol] (R-HSA-419173)	0.659	3
Q05397	4	PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393)	0.659	4
Q9Y2X7	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.659	4
Q9Y5K6	1	CD2AP [cytosol] (R-HSA-373620)	0.659	3
Q13905	1	RAPGEF1 [cytosol] (R-HSA-913472)	0.658	3
P27958	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
P29350	1	PTPN6 [cytosol] (R-HSA-197938)	0.646	3
Q14247	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.643	3
Q96P48	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.643	4
P18031	1	PTPN1 [cytosol] (R-HSA-210625)	0.642	4
P06400	4	hyperphosphorylated RB1 [nucleoplasm] (R-HSA-188389) RB1 [cytosol] (R-HSA-9660621) RB1 [nucleoplasm] (R-HSA-68642) RB1 T738_R775del [nucleoplasm] (R-HSA-9661042)	0.61	4
O14672	1	ADAM10 [plasma membrane] (R-HSA-157237)	0.602	5
O15357	1	INPPL1 [cytosol] (R-HSA-913354)	0.597	4
P30530	1	AXL [plasma membrane] (R-HSA-197705)	0.597	4
P34152	1	Fak1 [cytosol] (R-MMU-3928448)	0.597	3
O43597	2	p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.591	3
P98082	2	DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.573	2
P55072	2	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [cytosol] (R-HSA-1181251)	0.57	3
Q07869	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.57	3
Q8WXH5	1	SOCS4 [cytosol] (R-HSA-8936109)	0.57	3
O75369	1	FLNB [cytosol] (R-HSA-354163)	0.564	2
P19174	4	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682)	0.564	2
P21333	1	FLNA [cytosol] (R-HSA-210019)	0.564	2
Q15109	1	AGER [plasma membrane] (R-HSA-197639)	0.564	2
P14373	1	TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
P62324	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.556	3
Q08117	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
Q13352	1	ITGB3BP [cytosol] (R-HSA-3006405)	0.556	3
Q7L190	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
Q92841	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.556	3
Q96RU7	1	TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
Q9NRF2	1	SH2B1-2 [cytosol] (R-HSA-1675482)	0.556	3
Q9UIH9	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
Q09472	2	EP300 [nucleoplasm] (R-HSA-381325) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.553	2
Q8WUM4	1	PDCD6IP [cytosol] (R-HSA-917717)	0.553	2
P19338	1	NCL [nucleoplasm] (R-HSA-6791213)	0.547	2
Q06187	2	Active BTK [cytosol] (R-HSA-8964323) BTK [cytosol] (R-HSA-197948)	0.547	2
Q9Y2R2	1	PTPN22 [cytosol] (R-HSA-8852205)	0.544	2
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.527	3
P07355	2	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242)	0.527	2
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	3
P12236	1	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745)	0.527	2
P13639	7	ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) diphthine EEF2 [cytosol] (R-HSA-5358501) EEF2 [cytosol] (R-HSA-156901) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) Me3K525-EEF2 [cytosol] (R-HSA-8932237) nascent EEF2 [cytosol] (R-HSA-5358472)	0.527	2
P19105	2	MYL12A [cytosol] (R-HSA-390735) p-S19-MYL12A [cytosol] (R-HSA-390749)	0.527	2
P22626	1	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.527	2
P31946	1	YWHAB [cytosol] (R-HSA-48888)	0.527	3
P41240	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.527	2
P62258	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
P62805	11	AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	2
P62937	3	PPIA [cytosol] (R-HSA-173123) PPIA [extracellular exosome] (R-HSA-6801538) PPIA [extracellular region] (R-HSA-173646)	0.527	2
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	3
Q9Y230	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
Q9Y265	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	2
Q13177	9	K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-5S-PAK2 [cytosol] (R-HSA-211609) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) PAK2 [cytosol] (R-HSA-211604) PAK2(1-524) [plasma membrane] (R-HSA-164946) PAK2(213-524) [cytosol] (R-HSA-211653)	0.524	2
Q16236	6	NFE2L2 [cytosol] (R-HSA-201566) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) ub-NFE2L2 [cytosol] (R-HSA-9758077)	0.508	2
O14641	1	DVL2 [cytosol] (R-HSA-201694)	0.488	2
P40763	6	p-S727-STAT3 [cytosol] (R-HSA-198705) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044)	0.462	3

Cite Us!