Reactome | UniProt:Q00987 MDM2

UniProt:Q00987 MDM2

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

MDM2_HUMAN, A6NL51, A8K2S6, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q8WYJ1, Q8WYJ2, Q9UGI3, Q9UMT8

List of interactors in Reactome

Interactors (37)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P04637	2	polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 [nucleoplasm] (R-HSA-69488)	0.995	117
Q93009	1	USP7 [nucleoplasm] (R-HSA-3215278)	0.965	34
Q9UER7	2	DAXX [nucleoplasm] (R-HSA-3222068) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.895	18
P0CG48	10	UBC [cytosol] (R-HSA-8853531) UBC(1-76) [cytosol] (R-HSA-939188) UBC(153-228) [cytosol] (R-HSA-939258) UBC(229-304) [cytosol] (R-HSA-939192) UBC(305-380) [cytosol] (R-HSA-939232) UBC(381-456) [cytosol] (R-HSA-939191) UBC(457-532) [cytosol] (R-HSA-939184) UBC(533-608) [cytosol] (R-HSA-939239) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164)	0.821	6
P62081	1	RPS7 [nucleoplasm] (R-HSA-6790635)	0.817	17
Q8N726	3	p14ARF [cytosol] (R-HSA-9645669) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.813	5
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.807	6
Q00987	7	MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.736	4
P06400	4	hyperphosphorylated RB1 [nucleoplasm] (R-HSA-188389) RB1 [cytosol] (R-HSA-9660621) RB1 [nucleoplasm] (R-HSA-68642) RB1 T738_R775del [nucleoplasm] (R-HSA-9661042)	0.734	5
P49757	1	NUMB [plasma membrane] (R-HSA-443595)	0.718	7
P19338	2	NCL [nucleoplasm] (R-HSA-6791213) NCL [plasma membrane] (R-HSA-9836466)	0.71	8
P68104	4	EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.709	9
P32121	1	ARRB2 [cytosol] (R-HSA-416464)	0.708	5
P06748	6	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) NPM1 [cytosol] (R-HSA-3008211) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) p-S4-NPM1 [cytosol] (R-HSA-6801679) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056)	0.697	5
O96017	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.66	6
P49407	1	ARRB1 [cytosol] (R-HSA-264470)	0.641	3
P29067	1	Arrb2 [cytosol] (R-RNO-416464)	0.631	4
Q9H2X6	2	HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.62	5
Q71UM5	1	RPS27L [nucleoplasm] (R-HSA-6791197)	0.619	6
P61289	1	PSME3 [cytosol] (R-HSA-68816)	0.612	8
P48730	2	CSNK1D [cytosol] (R-HSA-380315) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717)	0.61	6
P29590	4	monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.609	6
P42677	1	RPS27 [nucleoplasm] (R-HSA-6791190)	0.602	5
P53350	4	p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603) PLK1 [nucleoplasm] (R-HSA-156720)	0.602	7
Q9Y297	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.591	9
P61978	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.589	2
P04271	1	S100B [extracellular region] (R-HSA-879433)	0.558	2
O15297	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.544	4
P78352	1	DLG4 [plasma membrane] (R-HSA-202135)	0.525	3
P05412	4	JUN [cytosol] (R-HSA-168194) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [cytosol] (R-HSA-8868682) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237)	0.524	3
P15311	1	EZR [cytosol] (R-HSA-9020826)	0.524	3
P48729	2	CSNK1A1 [cilium] (R-HSA-5632507) CSNK1A1 [cytosol] (R-HSA-195263)	0.524	3
P49674	1	CSNK1E [cytosol] (R-HSA-205877)	0.524	3
Q13616	1	CUL1 [cytosol] (R-HSA-174230)	0.524	3
Q15648	1	MED1 [nucleoplasm] (R-HSA-212445)	0.524	3
P03372	2	ESR1 [nucleoplasm] (R-HSA-446168) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302)	0.508	2
Q6P5F9	2	Xpo1 [cytosol] (R-MMU-165539) Xpo1 [nucleoplasm] (R-MMU-9769779)	0.499	4

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