Reactome | UniProt:Q96EB6 SIRT1

UniProt:Q96EB6 SIRT1

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

SIR1_HUMAN, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0

List of interactors in Reactome

Interactors (34)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P04637	2	polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 [nucleoplasm] (R-HSA-69488)	0.957	18
Q8N163	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.769	16
Q14191	2	monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904) WRN [nucleoplasm] (R-HSA-67387)	0.761	9
P26358	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.752	11
Q09472	2	EP300 [nucleoplasm] (R-HSA-381325) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.734	4
Q86WX3	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.733	11
Q04206	1	p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.729	5
O43524	9	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.704	5
Q12778	5	Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306)	0.702	4
Q01094	1	E2F1 [nucleoplasm] (R-HSA-68639)	0.656	3
Q13573	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.639	7
O60934	2	NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.632	5
P27695	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.619	6
P01106	1	MYC [nucleoplasm] (R-HSA-188379)	0.602	4
P23025	1	XPA [nucleoplasm] (R-HSA-67437)	0.602	8
P31749	7	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.602	5
Q9UBC3	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.597	4
Q13085	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.591	3
Q9Y4H2	1	IRS2 [cytosol] (R-HSA-57528)	0.589	2
P10276	2	polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.577	3
P37231	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.576	5
P04608	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	3
O43463	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.544	5
P04198	1	MYCN [nucleoplasm] (R-HSA-452357)	0.544	3
P36956	1	SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761)	0.544	2
P98177	4	Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655)	0.544	3
Q14469	1	HES1 [nucleoplasm] (R-HSA-210825)	0.544	4
Q9GZQ8	2	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651)	0.544	2
Q9UBP5	1	HEY2 [nucleoplasm] (R-HSA-1606745)	0.544	3
Q92831	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.525	3
O43159	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.524	3
P33076	1	CIITA [nucleoplasm] (R-HSA-1031702)	0.524	4
Q03164	2	KMT2A [cytosol] (R-HSA-9818584) KMT2A [nucleoplasm] (R-HSA-1183223)	0.508	5
Q15910	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.462	2