2021-05-04
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R-HSA-9725357
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NPM1-ALK-dependent CEBPB gene expression
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BibTex
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2021-05-04
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R-HSA-9725030
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MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner
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BibTex
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2021-05-04
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R-HSA-9701903
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ALK-, STAT3- and MECP2-dependent STAT5A gene repression
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BibTex
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2021-05-04
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R-HSA-9701810
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MECP2 binds the STAT5A gene
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BibTex
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2021-05-04
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R-HSA-9725338
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NPM1-ALK-dependent BCL2A1 gene expression
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BibTex
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2021-05-04
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R-HSA-9725023
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NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
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BibTex
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2021-05-04
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R-HSA-9725345
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NPM1-ALK-dependent JUNB translation
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BibTex
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2021-05-04
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R-HSA-9725342
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NPM1-ALK-dependent JUNB gene transcription
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BibTex
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2021-05-04
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R-HSA-9725009
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NPM1-ALK translocates to the nucleus
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BibTex
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2021-05-04
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R-HSA-9724090
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MYH9- and RNF213-ALK fusions are phosphorylated
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BibTex
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2021-05-04
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R-HSA-9724099
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ALK mutants:p-3Y SHC binds GRB2
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BibTex
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2021-05-04
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R-HSA-9700193
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ALK mutants phosphorylate SHC1
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BibTex
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2021-05-04
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R-HSA-9710914
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ALK fusions bind GRB2
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BibTex
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2021-05-04
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R-HSA-9700190
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ALK mutants bind SHC
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BibTex
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2021-05-04
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R-HSA-9712082
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ALK fusions phosphorylate IRS1
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BibTex
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2021-05-04
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R-HSA-9712088
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ALK fusion proteins bind IRS
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BibTex
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2021-05-04
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R-HSA-9712087
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ALK fusions phosphorylate FRS
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BibTex
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2021-05-04
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R-HSA-9712081
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ALK fusions bind FRS
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BibTex
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2021-05-04
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R-HSA-9712086
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ALK fusions phosphorylate PLCG1
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BibTex
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2021-05-04
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R-HSA-9710917
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ALK fusion proteins bind PLCG1
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BibTex
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2021-05-04
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R-HSA-9712085
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ALK mutants phosphorylate STAT3
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BibTex
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2021-05-04
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R-HSA-9712079
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ALK mutants bind STAT3
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BibTex
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2021-05-04
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R-HSA-9712084
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PI3K synthesizes PIP3 downstream of ALK mutants
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BibTex
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2021-05-04
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R-HSA-9712083
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ALK mutants bind PI3KCA
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BibTex
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2021-05-04
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R-HSA-9712078
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ALK mutants bind PI3KR1
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BibTex
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2021-05-04
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R-HSA-9700186
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Autophosphorylation of point mutants of ALK
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BibTex
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2021-05-04
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R-HSA-9700184
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Ligand-independent dimerization of point mutants of ALK
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BibTex
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2021-05-04
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R-HSA-9700181
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Autophosphorylation of ALK fusions
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BibTex
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2021-05-04
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R-HSA-9700179
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Ligand-independent dimerization of ALK fusions
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BibTex
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2021-05-04
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R-HSA-9700658
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ceritinib-resistant ALK mutants don't bind ceritinib
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BibTex
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2021-05-04
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R-HSA-9715357
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crizotinib-resistant ALK mutants don't bind crizotinib
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BibTex
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2021-05-04
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R-HSA-9715355
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lorlatinib-resistant ALK mutants don't bind lorlatinib
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BibTex
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2021-05-04
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R-HSA-9700646
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ASP-3026- resistant ALK mutants don't bind ASP-3026
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BibTex
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2021-05-04
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R-HSA-9715356
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brigatinib-resistant ALK mutants don't bind brigatinib
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BibTex
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2021-05-04
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R-HSA-9700114
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NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
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BibTex
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2021-05-04
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R-HSA-9700656
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alectinib resistant ALK mutants don't bind alectinib
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BibTex
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2021-05-04
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R-HSA-9667914
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ALK binds ligand midkine (MDK)
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BibTex
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2021-05-04
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R-HSA-201486
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ALK binds ligand pleiotrophin (PTN)
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BibTex
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2021-05-04
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R-HSA-9700662
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Liganded-ALK dimer binds type I ALK-binding TKIs
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BibTex
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2021-05-04
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R-HSA-9700131
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ALK mutants bind type I TKIs
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BibTex
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2021-05-04
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R-RNO-201531
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ALK dimerization
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BibTex
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2021-05-04
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R-HSA-201519
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ALK:PTN dimerization
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BibTex
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2021-05-04
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R-HSA-9700137
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ALK:MDK dimerization
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BibTex
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2021-05-04
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R-HSA-201521
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ALK autophosphorylation
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BibTex
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2021-05-04
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R-HSA-9701524
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STAT3 is phosphorylated downstream of active ALK
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BibTex
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2021-05-04
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R-HSA-9725332
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MYC/MYCN bind the ALK gene
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BibTex
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2021-05-04
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R-HSA-9701525
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p-Y705,S727-STAT3 dimerizes
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BibTex
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2021-05-04
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R-HSA-9701529
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p-Y705, p-S727 STAT3 dimer translocates to the nucleus
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BibTex
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2021-05-04
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R-NUL-9700145
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Active ALK binds Frs2
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BibTex
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2021-05-04
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R-HSA-9700142
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Active ALK binds FRS2
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BibTex
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2021-05-04
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R-NUL-9700161
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p-7Y ALK dimer phosphorylates Frs2
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BibTex
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2021-05-04
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R-HSA-9700164
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Active ALK phosphorylates FRS2
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BibTex
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2021-05-04
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R-HSA-9701485
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Active ALK binds JAK3
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BibTex
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2021-05-04
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R-HSA-9701488
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Active ALK phosphorylates JAK3
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BibTex
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2021-05-04
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R-HSA-9701507
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PTPN6 dephosphorylates JAK3
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BibTex
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2021-05-04
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R-HSA-9725315
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ALK-stimulated MYCN gene expression
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BibTex
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2021-05-04
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R-HSA-9700200
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PTPRZ dephosphorylates ligand-bound ALK dimers
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BibTex
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2021-05-04
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R-HSA-9700120
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PTN and MDK bind to PTPRZ
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BibTex
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2021-05-04
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R-HSA-9700121
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(PTN,MDK):PTPRZ oligomerizes
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BibTex
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2021-05-04
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R-HSA-9700154
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Active ALK binds SHC1
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BibTex
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2021-05-04
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R-HSA-9700175
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Active ALK phosphorylates SHC1
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BibTex
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2021-05-04
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R-HSA-9700156
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Active ALK dimer binds IRS1
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BibTex
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2021-05-04
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R-HSA-9700168
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Active ALK phosphorylates IRS1
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BibTex
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2021-05-04
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R-HSA-9701531
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p-Y705,S727 STAT3 is acetylated
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BibTex
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2021-05-04
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R-HSA-9701557
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AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter
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BibTex
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2021-05-04
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R-HSA-9701556
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IL2RG gene expression downstream of ALK signaling
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BibTex
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2021-05-04
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R-HSA-9701534
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p-Y705, S727 STAT3 dimer binds HIF1A gene
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BibTex
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2021-05-04
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R-HSA-9701569
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ALK- and STAT3-dependent HIF1A gene expression
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BibTex
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2021-05-04
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R-HSA-9701537
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p-Y705, S727 STAT3 dimer binds CD274 gene
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BibTex
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2021-05-04
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R-HSA-9701549
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AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter
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BibTex
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2021-05-04
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R-HSA-9701548
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PRDM1 gene expression downstream of ALK signaling
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BibTex
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2021-05-04
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R-HSA-9701565
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HDACs deacetylate p-STAT3 dimers
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BibTex
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2021-05-04
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R-HSA-9701562
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CD274 gene expression downstream of ALK signaling
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BibTex
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2021-05-04
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R-HSA-9700149
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Active ALK binds PLCG1
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BibTex
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2021-05-04
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R-HSA-9700171
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Active ALK phosphorylates PLCG1
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BibTex
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2021-05-04
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R-HSA-201515
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Active ALK recruits PI3K
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BibTex
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2021-05-04
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R-HSA-201510
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PI3K synthesizes PIP3 downstream of ALK
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BibTex
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2021-05-04
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R-HSA-9725117
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ALK gene expression
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BibTex
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2021-05-04
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R-NUL-9700661
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Active ALK binds Src
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BibTex
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2021-05-04
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R-HSA-9700648
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Active ALK binds SRC
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BibTex
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2021-05-04
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R-NUL-9700655
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Active ALK phosphorylates Src
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BibTex
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2021-05-04
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R-HSA-9700647
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Active ALK phosphorylates SRC
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BibTex
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