Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/197)
Date Identifier Pathway Reference
2021-02-17 R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 BibTex
2020-11-06 R-HSA-9682385 FLT3 signaling in disease BibTex
2020-11-06 R-HSA-9702506 Drug resistance of FLT3 mutants BibTex
2020-11-06 R-HSA-9702569 KW2449-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702600 midostaurin-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702632 sunitinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702605 pexidartinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702636 tandutinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9703009 tamatinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702624 sorafenib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702596 lestaurtinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702590 gilteritinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702620 quizartinib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702577 semaxanib-resistant FLT3 mutants BibTex
2020-11-06 R-HSA-9702998 linifanib-resistant FLT3 mutants BibTex
Authored Reactions (15/1,206)
Date Identifier Reaction Reference
2020-11-06 R-HSA-9702570 KW2449-resistant FLT3 mutants don't bind KW2449 BibTex
2020-11-06 R-HSA-9702601 midostaurin-resistant FLT3 mutants don't bind midostaurin BibTex
2020-11-06 R-HSA-9702629 sunitinib-resistant FLT3 mutants don't bind sunitinib BibTex
2020-11-06 R-HSA-9702607 pexidartinib-resistant FLT3 mutants don't bind pexidartinib BibTex
2020-11-06 R-HSA-9702638 tandutinib-resistant FLT3 mutants don't bind tandutinib BibTex
2020-11-06 R-HSA-9703008 tamatinib-resistant FLT3 mutants don't bind tamatinib BibTex
2020-11-06 R-HSA-9702623 sorafenib-resistant FLT3 mutants don't bind sorafenib BibTex
2020-11-06 R-HSA-9702593 lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib BibTex
2020-11-06 R-HSA-9702589 gilteritinib-resistant FLT3 mutants don't bind gilteritinib BibTex
2020-11-06 R-HSA-9702618 quizartinib-resistant FLT3 mutants don't bind quizartinib BibTex
2020-11-06 R-HSA-9702578 semaxanib-resistant FLT3 mutants don't bind semaxanib
BibTex
2020-11-06 R-HSA-9702997 linafinib-resistant FLT3 mutants don't bind linifanib BibTex
2020-11-06 R-HSA-9702613 ponatinib-resistant FLT3 mutants don't bind ponatinib BibTex
2020-11-06 R-HSA-9702583 crenolanib-resistant FLT3 mutants don't bind crenolanib BibTex
2020-11-06 R-HSA-9703434 FLT3 fusions recruit PIK3CA through PIK3R1 BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) BibTex
Reviewed Reactions (14/14)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2017-02-22 R-HSA-9690534 SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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