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Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Reactions (1,283)
Date Identifier Reaction Reference
2021-05-03 R-RNO-201531 ALK dimerization BibTex
2021-03-30 R-HSA-9725338 NPM-ALK-dependent BCL2A1 gene expression BibTex
2021-03-30 R-HSA-9725357 NPM-ALK-dependent CEBPB gene expression BibTex
2021-03-30 R-HSA-9725342 NPM-ALK-dependent JUNB gene transcription BibTex
2021-03-30 R-HSA-9725345 NPM-ALK-dependent JUNB translation BibTex
2021-03-30 R-HSA-9725009 NPM-ALK translocates to the nucleus BibTex
2021-03-30 R-HSA-9725023 NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 BibTex
2021-03-30 R-HSA-9725030 MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner BibTex
2021-03-30 R-HSA-9700200 PTPRZ dephosphorylates ligand-bound ALK dimers BibTex
2021-03-30 R-NUL-9700655 Active ALK phosphorylates Src BibTex
2021-03-30 R-NUL-9700661 Active ALK binds Src BibTex
2021-03-30 R-HSA-9700648 Active ALK binds SRC BibTex
2021-03-30 R-HSA-9700647 Active ALK phosphorylates SRC BibTex
2021-03-30 R-HSA-9725117 ALK gene expression BibTex
2021-03-30 R-HSA-9700149 Active ALK binds PLCG1 BibTex
2021-03-30 R-HSA-9700171 Active ALK phosphorylates PLCG1 BibTex
2021-03-30 R-HSA-9701562 CD274 gene expression downstream of ALK signaling BibTex
2021-03-30 R-HSA-9701565 HDACs deacetylate p-STAT3 dimers BibTex
2021-03-30 R-HSA-9701549 AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter BibTex
2021-03-30 R-HSA-9701548 PRDM1 gene expression downstream of ALK signaling BibTex
2021-03-30 R-HSA-9701537 p-Y705, S727 STAT3 dimer binds CD274 gene BibTex
2021-03-30 R-HSA-9701534 p-Y705, S727 STAT3 dimer binds HIF1A gene BibTex
2021-03-30 R-HSA-9700662 (PTN/MDK):ALK dimer binds type I ALK-binding TKIs BibTex
2021-03-30 R-HSA-9701524 STAT3 is phosphorylated downstream of active ALK BibTex
2021-03-30 R-HSA-9700137 ALK:MDK dimerization BibTex
2021-03-30 R-HSA-9725332 MYC/MYCN bind the ALK gene BibTex
2021-03-30 R-HSA-9701525 p-Y705,S727-STAT3 dimerizes BibTex
2021-03-30 R-HSA-9700120 PTN and MDK bind to PTPRZ BibTex
2021-03-30 R-HSA-9700121 (PTN,MDK):PTPRZ oligomerizes BibTex
2021-03-30 R-HSA-9701529 p-Y705, p-S727 STAT3 dimer translocates to the nucleus BibTex
2021-03-30 R-HSA-9700164 Active ALK phosphorylates FRS2 BibTex
2021-03-30 R-HSA-9700142 Active ALK binds FRS2 BibTex
2021-03-30 R-NUL-9700145 Active ALK binds Frs2 BibTex
2021-03-30 R-NUL-9700161 p-7Y ALK dimer phosphorylates Frs2 BibTex
2021-03-30 R-HSA-9701507 PTPN6 dephosphorylates JAK3 BibTex
2021-03-30 R-HSA-9701488 Active ALK phosphorylates JAK3 BibTex
2021-03-30 R-HSA-9701485 Active ALK binds JAK3 BibTex
2021-03-30 R-HSA-9725315 ALK-stimulated MYCN gene expression BibTex
2021-03-30 R-HSA-9700175 Active ALK phosphorylates SHC1 BibTex
2021-03-30 R-HSA-9700154 Active ALK binds SHC1 BibTex
2021-03-30 R-HSA-9700168 Active ALK phosphorylates IRS1 BibTex
2021-03-30 R-HSA-9700156 Active ALK dimer binds IRS1 BibTex
2021-03-30 R-HSA-9701556 IL2RG gene expression downstream of ALK signaling BibTex
2021-03-30 R-HSA-9701557 AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter BibTex
2021-03-30 R-HSA-9701531 p-Y705,S727 STAT3 is acetylated BibTex
2021-03-30 R-HSA-9701569 ALK- and STAT3-dependent HIF1A gene expression BibTex
2021-03-22 R-HSA-9724099 ALK mutants:p-3Y SHC binds GRB2 BibTex
2021-03-22 R-HSA-9710914 ALK fusions bind GRB2 BibTex
2021-03-22 R-HSA-9700193 ALK mutants phosphorylate SHC1 BibTex
2021-03-22 R-HSA-9701903 ALK-, STAT3- and MECP2-dependent STAT5A gene repression BibTex
2021-03-22 R-HSA-9701810 MECP2 binds the STAT5A gene BibTex
2021-03-22 R-HSA-9724090 MYH9- and RNF213-ALK fusions are phosphorylated BibTex
2021-03-22 R-HSA-9700190 ALK mutants bind SHC BibTex
2021-03-22 R-HSA-9712088 ALK fusion proteins bind IRS BibTex
2021-03-22 R-HSA-9712082 ALK fusions phosphorylate IRS1 BibTex
2021-03-22 R-HSA-9712081 ALK fusions bind FRS BibTex
2021-03-22 R-HSA-9712087 ALK fusions phosphorylate FRS BibTex
2021-03-22 R-HSA-9710917 ALK fusion proteins bind PLCG1 BibTex
2021-03-22 R-HSA-9712086 ALK fusions phosphorylate PLCG1 BibTex
2021-03-22 R-HSA-9712079 ALK mutants bind STAT3 BibTex
2021-03-22 R-HSA-9712085 ALK mutants phosphorylate STAT3 BibTex
2021-03-22 R-HSA-9700184 Ligand-independent dimerization of point mutants of ALK BibTex
2021-03-22 R-HSA-9700186 Autophosphorylation of point mutants of ALK BibTex
2021-03-22 R-HSA-9700179 Ligand-independent dimerization of ALK fusions BibTex
2021-03-22 R-HSA-9700181 Autophosphorylation of ALK fusions BibTex
2021-03-22 R-HSA-9712078 ALK mutants bind PI3KR1 BibTex
2021-03-22 R-HSA-9712083 ALK mutants bind PI3KCA BibTex
2021-03-22 R-HSA-9712084 PI3K synthesizes PIP3 downstream of ALK mutants BibTex
2021-03-22 R-HSA-9700658 ceritinib-resistant ALK mutants don't bind ceritinib BibTex
2021-03-22 R-HSA-9715357 crizotinib-resistant ALK mutants don't bind crizotinib BibTex
2021-03-22 R-HSA-9715355 lorlatinib-resistant ALK mutants don't bind lorlatinib BibTex
2021-03-22 R-HSA-9700646 ASP-3026- resistant ALK mutants don't bind ASP-3026 BibTex
2021-03-22 R-HSA-9715356 brigatinib-resistant ALK mutants don't bind brigatinib BibTex
2021-03-22 R-HSA-9700114 NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 BibTex
2021-03-22 R-HSA-9700656 alectinib resistant ALK mutants don't bind alectinib BibTex
2021-03-22 R-HSA-9700131 ALK mutants bind type I TKIs BibTex
2020-11-06 R-HSA-9702570 KW2449-resistant FLT3 mutants don't bind KW2449 BibTex
2020-11-06 R-HSA-9702601 midostaurin-resistant FLT3 mutants don't bind midostaurin BibTex
2020-11-06 R-HSA-9702629 sunitinib-resistant FLT3 mutants don't bind sunitinib BibTex
2020-11-06 R-HSA-9702607 pexidartinib-resistant FLT3 mutants don't bind pexidartinib BibTex
2020-11-06 R-HSA-9702638 tandutinib-resistant FLT3 mutants don't bind tandutinib BibTex
2020-11-06 R-HSA-9703008 tamatinib-resistant FLT3 mutants don't bind tamatinib BibTex
2020-11-06 R-HSA-9702623 sorafenib-resistant FLT3 mutants don't bind sorafenib BibTex
2020-11-06 R-HSA-9702593 lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib BibTex
2020-11-06 R-HSA-9702589 gilteritinib-resistant FLT3 mutants don't bind gilteritinib BibTex
2020-11-06 R-HSA-9702618 quizartinib-resistant FLT3 mutants don't bind quizartinib BibTex
2020-11-06 R-HSA-9702578 semaxanib-resistant FLT3 mutants don't bind semaxanib
BibTex
2020-11-06 R-HSA-9702997 linafinib-resistant FLT3 mutants don't bind linifanib BibTex
2020-11-06 R-HSA-9702613 ponatinib-resistant FLT3 mutants don't bind ponatinib BibTex
2020-11-06 R-HSA-9702583 crenolanib-resistant FLT3 mutants don't bind crenolanib BibTex
2020-11-06 R-HSA-9703434 FLT3 fusions recruit PIK3CA through PIK3R1 BibTex
2020-11-06 R-HSA-9703435 FLT3 fusions activate STAT5 BibTex
2020-11-06 R-HSA-9703432 p-STAT5 dissociates from FLT3 fusion proteinsp- BibTex
2020-11-06 R-HSA-9703439 FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 BibTex
2020-11-06 R-HSA-9703438 FLT3 fusions phosphorylate GAB2 BibTex
2020-11-06 R-HSA-9703430 FLT3 fusions:GRB2 bind SOS1 BibTex
2020-11-06 R-HSA-9703441 SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants BibTex
2020-11-06 R-HSA-9703433 Ligand-independent dimerization of FLT3 fusion proteins BibTex
2020-11-06 R-HSA-9703437 FLT3 fusion dimers autophosphorylate BibTex
2020-11-06 R-HSA-9703442 Phosphorylated FLT3 fusions bind GRB2 BibTex
2020-11-06 R-HSA-9703440 FLT3 fusions:GRB2 bind GAB2 BibTex
2020-11-06 R-HSA-9706356 CBL mutants don't ubiquitinate FLT3 BibTex
2020-11-06 R-HSA-9702510 FLT mutants bind type II TKIs BibTex
2020-11-06 R-HSA-9702508 FLT mutants bind type I TKIs BibTex
2020-11-06 R-HSA-9706345 Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA BibTex
2020-11-06 R-HSA-9706344 FLT3 phosphorylates GRB10 BibTex
2020-11-06 R-HSA-9706340 Active FLT3:p-Y-GRB10 binds PIK3R1 BibTex
2020-11-06 R-HSA-9699578 Active FLT3 phosphorylates CDKN1B BibTex
2020-11-06 R-HSA-9699579 AKT phosphorylates FOXO3 downstream of FLT3 BibTex
2020-11-06 R-HSA-9699581 AKT-phosphorylated FOXO3 translocates to cytosol BibTex
2020-11-06 R-HSA-9699575 FOXO3-dependent CDKN1B gene expression BibTex
2020-11-06 R-HSA-9699574 FOXO3-dependent BCL2L11 gene expression BibTex
2020-11-06 R-HSA-9706315 Active FLT3 binds to SH2B3 BibTex
2020-11-06 R-HSA-9706298 Active FLT3 binds to CSK BibTex
2020-11-06 R-HSA-9706330 Active FLT3 binds to SOCS6 BibTex
2020-11-06 R-HSA-9706328 Active FLT3 binds to SOCS2 BibTex
2020-11-06 R-HSA-9706287 Active FLT3 binds to ABL2 BibTex
2020-11-06 R-HSA-9706319 Active FLT3 binds to SLA BibTex
2020-11-06 R-HSA-9698408 PTPRJ dephosphorylates active FLT3 BibTex
2020-11-06 R-HSA-9706364 Internalization of ubiquitinated FLT3 BibTex
2020-11-06 R-HSA-9706323 Active FLT3 binds to SLA2 BibTex
2020-11-06 R-HSA-9706350 FLT3 phosphorylates CBL BibTex
2020-11-06 R-HSA-9706354 Ubiquitination of FLT3 BibTex
2020-11-06 R-HSA-9706293 Active FLT3 binds to CBL BibTex
2020-11-06 R-HSA-9706304 Active FLT3 binds to GRAP2 BibTex
2020-11-06 R-HSA-9706312 Active FLT3 binds to LCK BibTex
2020-11-06 R-HSA-9706336 Active FLT3 binds to SYK BibTex
2020-11-06 R-HSA-9706308 Active FLT3 binds to GRB10 BibTex
2020-11-06 R-HSA-9695828 FLT3 binds type I TKI BibTex
2020-11-06 R-HSA-9695831 FLT3 binds type II TKI BibTex
2020-11-06 R-HSA-9695853 FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS BibTex
2020-11-06 R-HSA-9698003 FLT3 mutants phosphorylate GAB2 BibTex
2020-11-06 R-HSA-9698000 FLT3 mutants:GRB2 bind GAB2 BibTex
2020-11-06 R-HSA-9695841 FLT3 mutant dimers bind GRB2 BibTex
2020-11-06 R-HSA-9695834 Constitutive phosphorylation of FLT3 mutants BibTex
2020-11-06 R-HSA-9695838 Ligand-independent dimerization of FLT3 mutants BibTex
2020-11-06 R-HSA-9698179 FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 BibTex
2020-11-06 R-HSA-9698033 p-STAT5 translocates to nucleus downstream of mutant FLT3 BibTex
2020-11-06 R-HSA-9698029 p-STAT5 dissociates from mutant FLT3 BibTex
2020-11-06 R-HSA-9698005 FLT3 ITD mutants phosphorylate STAT5 BibTex
2020-11-06 R-HSA-9698007 FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 BibTex
2020-11-06 R-HSA-9698008 FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 BibTex
2020-11-06 R-HSA-9698043 FLT3 ITD- and STAT5-dependent CDKN1A gene expression BibTex
2020-11-06 R-HSA-9698041 p-STAT5 binds the CDKN1A gene BibTex
2020-11-06 R-HSA-9698013 PTPN11:p-STAT5 dissociates from mutant FLT3 BibTex
2020-11-06 R-HSA-9698754 p-STAT5 binds the NOX4 promoter BibTex
2020-11-06 R-HSA-9698016 PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 BibTex
2020-11-06 R-HSA-9698758 FLT3 ITD- and NOX4-dependent H2O2 production BibTex
2020-11-06 R-HSA-9698762 FLT3 ITD- and STAT5-dependent NOX4 gene expression BibTex
2020-11-06 R-HSA-9698021 PTPN11:p-STAT5 binds BCL2L1 promoter BibTex
2020-11-06 R-HSA-9703436 STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants BibTex
2020-11-06 R-HSA-9698026 FLT3 ITD- and STAT5-dependent BCL2L1 gene expression BibTex
2020-11-06 R-HSA-9695845 FLT3 mutant dimers:GRB2 bind SOS1 BibTex
2020-11-06 R-HSA-9698170 Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA BibTex
2020-11-06 R-HSA-9698174 FLT3 mutants recruit PIK3CA through PIK3R1 BibTex
2020-07-30 R-HSA-9694455 SUMO-p-N protein dimer binds genomic RNA BibTex
2020-07-30 R-HSA-9694281 Encapsidation of SARS coronavirus genomic RNA BibTex
2020-07-30 R-HSA-9694487 M protein oligomerization BibTex
2020-07-30 R-HSA-9694444 E and N are recruited to the M lattice BibTex
2020-07-30 R-HSA-9694553 Recruitment of Spike trimer to assembling virion BibTex
2020-07-30 R-HSA-9694528 Accessory proteins are recruited to the maturing virion BibTex
2020-07-30 R-HSA-9694633 SARS virus buds into ERGIC lumen BibTex
2020-07-30 R-HSA-9694641 Viral release BibTex
2020-07-14 R-HSA-9013158 CDC42 GDIs block activation of CDC42 BibTex
2020-07-14 R-HSA-9013157 CDC42 binds effectors at the plasma membrane BibTex
2020-07-14 R-HSA-9692809 CDC42 binds effectors at the ER membrane BibTex
2020-07-14 R-HSA-9692800 CDC42 translocates to the endoplasmic reticulum membrane BibTex
2020-07-14 R-HSA-9013159 CDC42 GEFs activate CDC42 BibTex
2020-07-14 R-HSA-9013161 CDC42 GAPs stimulate CDC42 GTPase activity BibTex
2020-07-14 R-HSA-9014294 RAC2 binds effectors at the plasma membrane BibTex
2020-07-14 R-HSA-9014295 RAC2 GAPs stimulate RAC2 GTPase activity BibTex
2020-07-14 R-HSA-9014293 RAC2 GDIs block activation of RAC2 BibTex
2020-07-14 R-HSA-9714477 RAC2 binds effectors at the mitochondrial outer membrane BibTex
2020-07-14 R-HSA-9714483 RAC2 translocates to the ER membrane BibTex
2020-07-14 R-HSA-9714481 RAC2 binds effectors at the ER membrane BibTex
2020-07-14 R-HSA-9714480 RAC2 translocates to the mitochondrial membrane BibTex
2020-07-14 R-HSA-9014420 RAC2 translocates to the phagocytic vesicle membrane BibTex
2020-07-14 R-HSA-9014424 RAC2 binds effectors at the phagocytic vesicle membrane BibTex
2020-07-14 R-HSA-9014296 RAC2 GEFs activate RAC2 BibTex
2020-07-14 R-HSA-9691174 RAC1 binds effectors at the ER membrane BibTex
2020-07-14 R-HSA-9691168 RAC1 translocates to the endoplasmic reticulum membrane BibTex
2020-07-14 R-HSA-9013147 RAC1 GDIs block activation of RAC1 BibTex
2020-07-14 R-HSA-9013144 RAC1 GAPs stimulate RAC1 GTPase activity BibTex
2020-07-14 R-HSA-9013143 RAC1 GEFs activate RAC1 BibTex
2020-07-14 R-HSA-9013145 RAC1 binds effectors at the plasma membrane BibTex
2020-07-14 R-HSA-9018806 RAC3 GAPs stimulate RAC3 GTPase activity BibTex
2020-07-14 R-HSA-9018807 RAC3 GDIs block activation of RAC3 BibTex
2020-07-14 R-HSA-9714691 RAC3 binds ER effectors BibTex
2020-07-14 R-HSA-9714694 RAC3 translocates to the endoplasmic reticulum membrane BibTex
2020-07-14 R-HSA-9018804 RAC3 GEFs activate RAC3 BibTex
2020-07-14 R-HSA-9018808 RAC3 binds effectors at the plasma membrane BibTex
2020-04-22 R-HSA-9684234 Encapsidation of SARS coronavirus genomic RNA BibTex
2020-04-22 R-HSA-9684238 E and N are recruited to the M lattice BibTex
2020-04-22 R-HSA-9684241 Recruitment of Spike trimer to assembling virion BibTex
2020-04-22 R-HSA-9686174 Accessory proteins are recruited to the maturing virion BibTex
2020-04-22 R-HSA-9685531 SARS virus buds into ERGIC lumen BibTex
2020-04-22 R-HSA-9685542 Viral release BibTex
2020-04-22 R-HSA-9684229 SUMO-p-N protein dimer binds genomic RNA BibTex
2020-04-22 R-HSA-9684218 M protein oligomerization BibTex
2020-04-01 R-HSA-9669893 KIT binds type I TKIs BibTex
2020-04-01 R-HSA-9680248 Phosphorylation of extracellular domain KIT mutants BibTex
2020-04-01 R-HSA-9670426 Disassociation and translocation of STATs to the nucleus downstream of KIT mutants BibTex
2020-04-01 R-HSA-9670428 KIT mutants bind GRB2-SOS BibTex
2020-04-01 R-HSA-9670436 p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS BibTex
2020-04-01 R-HSA-9670416 Recruitment of STATs by KIT mutants BibTex
2020-04-01 R-HSA-9670412 Phosphorylation of STATs downstream of KIT mutants BibTex
2020-04-01 R-HSA-9670417 Dimerization of STATs downstream of KIT mutants BibTex
2020-04-01 R-HSA-9670431 Phosphorylated KIT mutants bind PI3K BibTex
2020-04-01 R-HSA-9670433 KIT mutants:PI3K catalyze synthesis of PIP3 BibTex
2020-04-01 R-HSA-9669906 Ligand-independent dimerization of KIT juxtamembrane domain mutants BibTex
2020-04-01 R-HSA-9669911 Phosphorylation of juxtamembrane domain KIT mutants BibTex
2020-04-01 R-HSA-9669890 Constitutive phosphorylation of kinase domain KIT mutants BibTex
2020-04-01 R-HSA-9670414 KIT mutants bind SFKs BibTex
2020-04-01 R-HSA-9670413 JAK2 binds to p-KIT mutants BibTex
2020-04-01 R-HSA-9670418 Phosphorylation of JAK2 downstream of KIT mutants BibTex
2020-04-01 R-HSA-9669859 Imatinib-resistant KIT mutants do not bind imatinib BibTex
2020-04-01 R-HSA-9669878 Sunitinib-resistant KIT mutants do not bind sunitinib BibTex
2020-04-01 R-HSA-9669870 Regorafenib-resistant KIT mutants do not bind regorafenib BibTex
2020-04-01 R-HSA-9669855 Dasatinib-resistant KIT mutants do not bind dasatinib BibTex
2020-04-01 R-HSA-9669863 Masitinib-resistant KIT mutants do not bind masitinib BibTex
2020-04-01 R-HSA-9669868 Nilotinib-resistant KIT mutants do not bind nilotinib BibTex
2020-04-01 R-HSA-9669874 Sorafenib-resistant KIT mutants do not bind sorafenib BibTex
2020-04-01 R-HSA-9669900 KIT mutants bind type II TKIs BibTex
2020-04-01 R-HSA-9669898 KIT mutants bind type I TKIs BibTex
2020-04-01 R-HSA-9669854 KIT binds type II TKIs BibTex
2020-04-01 R-HSA-9681375 KIT binds ripretinib BibTex
2020-03-25 R-HSA-9680242 Ligand-independent dimerization of KIT extracellular domain mutants BibTex
2020-02-25 R-HSA-9674430 PDGFR mutants bind type II TKIs BibTex
2020-02-25 R-HSA-9674427 PDGFR mutants bind type I TKIs BibTex
2020-02-25 R-HSA-9674397 Imatinib-resistant PDGFR mutants don't bind imatinib BibTex
2020-02-25 R-HSA-9674414 Sorafenib-resistant PDGFR mutants don't bind sorefenib BibTex
2020-02-25 R-HSA-9674398 D842V PDGFRA doesn't bind sunitinib BibTex
2020-02-25 R-HSA-9674408 Regorafenib-resistant PDGFR mutants don't bind regorafenib BibTex
2020-02-25 R-HSA-9674093 PDGFRs bind type I TKI BibTex
2020-02-25 R-HSA-9674095 PDGFRs bind type II TKI BibTex
2020-02-25 R-HSA-9674015 Olaratumab binds PDGFRA BibTex
2020-02-25 R-HSA-9672177 PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR BibTex
2020-02-25 R-HSA-9672172 PI3-kinase binds to mutant PDGFR receptor BibTex
2020-02-25 R-HSA-9672175 Autophosphorylation of PDGFR mutant dimers BibTex
2020-02-25 R-HSA-9672168 Ligand-independent dimerization of PDGFR mutants BibTex
2020-02-25 R-HSA-9672176 STAT binds to the mutant PDGFRA receptor BibTex
2020-02-25 R-HSA-9672164 GRB2:SOS1 complex binds to mutant PDGFR receptor BibTex
2020-02-25 R-HSA-9672170 SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors BibTex
2020-02-25 R-HSA-9673757 Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins BibTex
2020-02-25 R-HSA-9673756 Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins BibTex
2020-02-25 R-HSA-9672163 SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9672158 GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9672173 Autophosphorylation of PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9672174 Ligand-independent dimerization of PDGFRA extracellular domain mutants BibTex
2020-02-25 R-HSA-9672178 PI3-kinase binds to PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9672162 PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9672159 STAT binds to p-11Y PDGFRA extracellular domain dimers BibTex
2020-02-25 R-HSA-9673761 Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB BibTex
2020-02-25 R-HSA-9673760 Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB BibTex
2019-10-28 R-HSA-9635739 PTPN7 dephosphorylates p-T,Y-MAPKs BibTex
2019-10-28 R-HSA-9635743 PTPN7 binds p-T,Y-MAPK BibTex
2019-10-25 R-HSA-9647978 pro-RAS proteins are farnesylated BibTex
2019-10-25 R-HSA-9647999 RCE1 cleaves S-Farn proRAS proteins BibTex
2019-10-25 R-HSA-9647977 ICMT methylates S-Farn RAS proteins BibTex
2019-10-25 R-HSA-9647982 S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated BibTex
2019-10-25 R-HSA-9647980 mature RAS proteins translocate to plasma membrane BibTex
2019-10-25 R-HSA-9649732 Mature S-Farn-Me KRAS4B translocates to plasma membrane BibTex
2019-10-25 R-HSA-9649733 mature p21 RAS binds GDP BibTex
2019-10-25 R-HSA-9649736 RAS intrinsic GTPase activity hydrolyzes GTP to GDP BibTex
2019-10-25 R-HSA-9649735 Intrinsic nucleotide exchange on RAS BibTex
2019-10-25 R-HSA-9660557 RAS:GTP binds RAL GDS proteins BibTex
2019-10-25 R-HSA-9658253 RAS:GTP binds PI3K BibTex
2019-10-25 R-HSA-9658445 MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs BibTex
2019-10-25 R-HSA-9653108 Raf dimer inhibitors bind RAF heterodimers BibTex
2019-10-25 R-HSA-9657599 Dual mechanism MAP2K inhibitors bind MAP2Ks BibTex
2019-10-25 R-HSA-9657603 Dual mechanism MAPK inhibitors bind MAPKs BibTex
2019-10-25 R-HSA-9657606 Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks BibTex
2019-10-25 R-HSA-9657608 Single mechanism MAPK inhibitors bind phosphorylated MAPK BibTex
2019-10-25 R-HSA-9647987 FNTB inhibitors bind FNTA:FNTB BibTex
2019-10-25 R-HSA-9653585 S-Farn-Me KRAS4B binds calmodulin BibTex
2019-10-25 R-HSA-9654521 Calmodulin dissociates KRAS4B from the plasma membrane BibTex
2019-10-25 R-HSA-9654525 PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ BibTex
2019-10-25 R-HSA-9654523 ARL2:GTP bind PDE6D on KRAS4B BibTex
2019-10-25 R-HSA-9653503 KRAS4B is phosphorylated on serine 181 BibTex
2019-10-25 R-HSA-9653592 pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane BibTex
2019-10-25 R-HSA-9653595 pS181-S-Farn-Me KRAS4B binds BCL2L1 BibTex
2019-10-25 R-HSA-9647994 RAS proteins are depalmitoylated BibTex
2019-10-25 R-HSA-9647991 Palmostatin B binds RAS depalmitoylases BibTex
2019-10-25 R-HSA-9654533 KRAS4B recycles to the plasma membrane BibTex
2019-10-25 R-HSA-9653514 USP17L2 deubiquitinates RCE1 BibTex
2019-10-25 R-HSA-9656775 Cysmethynil binds ICMT:Zn2+ BibTex
2019-10-25 R-HSA-9656781 Deltarasin binds PDE6D BibTex
2019-10-25 R-HSA-9652816 Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs BibTex
2019-10-25 R-HSA-9652165 MAP2K mutants constitutively phosphorylate MAPKs BibTex
2019-10-25 R-HSA-9660536 SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex BibTex
2019-10-25 R-HSA-9660538 Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs BibTex
2019-10-25 R-HSA-9656211 MAP2Ks and MAPKs bind to the activated mutant RAF1 complex BibTex
2019-10-25 R-HSA-9656212 Phosphorylation of RAF1 mutants BibTex
2019-10-25 R-HSA-9656213 RAF1 mutants show enhanced heterodimerization with BRAF BibTex
2019-10-25 R-HSA-9656209 Dissociation of RAS:RAF1 mutant complex BibTex
2019-10-25 R-HSA-9656214 MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants BibTex
2019-10-25 R-HSA-9656215 RAF1 mutant complexes phosphorylate MAP2K dimer BibTex
2019-10-25 R-HSA-9656207 CR2 RAF1 mutants don't bind YWHAB BibTex
2019-10-25 R-RNO-9616370 MyrG-Cdk5r1(2-307) binds Cdk5 BibTex
2019-08-16 R-HSA-9612076 p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters BibTex
2019-08-16 R-NUL-9616362 NAB2 binds Egr1 at the Cdk5r1 promoter BibTex
2019-08-16 R-HSA-9616367 NAB2 binds EGR1 to repress CDK5R1 gene expression BibTex
2019-08-16 R-HSA-9612073 NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression BibTex
2019-08-16 R-HSA-9613219 RRAD gene expression BibTex
2019-08-16 R-HSA-9621054 REST binds the VGF promoter BibTex
2019-08-16 R-RNO-9619853 Arc binds Sh3gl3 and Dnm2 BibTex
2019-08-16 R-HSA-9619838 ARC binds DNM2 and SH3GL3 BibTex
2019-08-16 R-RNO-9621024 Egr1 binds the Tph1 promoter BibTex
2019-08-16 R-HSA-9621032 EGR1 binds the TPH1 promoter BibTex
2019-08-16 R-HSA-9621048 TPH1 gene expression BibTex
2019-08-16 R-HSA-9613476 EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions BibTex
2019-08-16 R-HSA-9612534 Expression of ID2 and ID4 is repressed by EGR2:NAB BibTex
2019-08-16 R-RNO-9616102 Egr1 binds Cdk5r1 gene BibTex
2019-08-16 R-HSA-9616105 EGR1 binds CDK5R1 gene BibTex
2019-08-16 R-HSA-9616110 EGR1-dependent CDK5R1 gene expression BibTex
2019-08-16 R-HSA-9616368 MyrG-CDK5R1,2 bind CDK5 BibTex
2019-08-16 R-RNO-9620716 p-Creb, Ascl1, Tcf12, p300 bind the vgf promoter BibTex
2019-08-16 R-HSA-9620717 p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter BibTex
2019-08-16 R-HSA-9620663 EGR1 binds the VGF gene BibTex
2019-08-16 R-HSA-9620723 VGF gene expression BibTex
2019-08-16 R-HSA-9621035 EGR1 binds the TF gene BibTex
2019-08-16 R-HSA-9621042 TF gene expression BibTex
2019-08-16 R-HSA-9612493 EGR-dependent NAB2 gene expression BibTex
2019-08-16 R-RNO-9621388 Egr1 binds the Trib1 gene BibTex
2019-08-16 R-HSA-9621385 EGR1 binds TRIB1 gene BibTex
2019-08-16 R-HSA-9621386 TRIB1 gene expression BibTex
2019-08-16 R-HSA-9612483 EGR1,2,3 bind the NAB2 promoter BibTex
2019-08-16 R-HSA-9613451 p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes BibTex
2019-08-16 R-HSA-9613460 ID1 and ID3 gene expression BibTex
2019-08-16 R-HSA-9613207 EGR1 binds to the EGR1 promoter BibTex
2019-08-16 R-RNO-9620373 Ap-1 dimers bind Arc gene BibTex
2019-08-16 R-HSA-9612501 SGK phosphorylates CREB1 BibTex
2019-08-16 R-HSA-9613213 NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression BibTex
2019-08-16 R-HSA-9613210 EGR1, EGR2 bind the RRAD promoter BibTex
2019-08-16 R-HSA-9612516 EGR1 gene expression BibTex
2019-08-16 R-HSA-9612514 p-S133 CREB and p-S103 SRF bind the EGR1 promoter BibTex
2019-08-16 R-HSA-9612509 SGK phosphorylates SRF BibTex
2019-08-16 R-HSA-9614271 Autocleavage of ADGRG6 BibTex
2019-08-16 R-HSA-9614273 ADGRG heterodimer translocates to plasma membrane BibTex
2019-08-16 R-HSA-9619666 L-PRX:DRP2 binds dystroglycan and laminin-211 BibTex
2019-08-16 R-HSA-9619669 L-PRX dimer binds DRP2 BibTex
2019-08-16 R-HSA-9619667 PRX gene expression BibTex
2019-08-16 R-HSA-9619657 EGR2 and SOX10 bind the PRX gene BibTex
2019-08-16 R-RNO-9619658 Egr2 and Sox10 bind the Prx promoter BibTex
2019-08-16 R-MMU-9619662 Prx binds Drp2 BibTex
2019-08-16 R-MMU-9619664 L:Prx:Drp2 binds dystroglycan BibTex
2019-08-16 R-BTA-9619663 alpha-dystroglycan binds laminin-211 BibTex
2019-08-16 R-HSA-9613648 SOX10 dimer binds the POU3F1 promoter BibTex
2019-08-16 R-RNO-9614293 Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination BibTex
2019-08-16 R-HSA-9615638 EGR2 and SOX10 bind the MBP gene BibTex
2019-08-16 R-RNO-9615634 Egr2 and Sox10 bind Mbp1 gene BibTex
2019-08-16 R-HSA-9621399 SCD5 gene expression BibTex
2019-08-16 R-HSA-9621400 EGR2 and SREBF2 dimer bind SCD5 gene BibTex
2019-08-16 R-HSA-9619668 L-PRX:DRP:DGC:laminin-211 interacts with UTRN BibTex
2019-08-16 R-MMU-9619682 Utrn interacts with a complex purified with an anti-periaxin antibody BibTex
2019-08-16 R-HSA-9621406 EGR2 and SREBF2 dimer bind CYP51A1 gene BibTex
2019-08-16 R-HSA-9621404 CYP51A1 gene expression BibTex
2019-08-16 R-HSA-9614787 MPZ gene expression BibTex
2019-08-16 R-HSA-9614790 EGR2, SOX10 and SMARCA4 bind the MPZ gene BibTex
2019-08-16 R-RNO-9614784 Egr2, Sox10 and Smarca4 bind the Mpz gene BibTex
2019-08-16 R-HSA-9613760 EGR2 gene expression BibTex
2019-08-16 R-HSA-9613768 SOX10, POU3F1 and POU3F2 bind EGR2 gene BibTex
2019-08-16 R-HSA-9615626 PMP22 gene expression BibTex
2019-08-16 R-HSA-9618559 EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene BibTex
2019-08-16 R-HSA-9613644 SOX10-dependent POU3F1 gene expression BibTex
2019-08-16 R-HSA-9616116 EGR2 and SOX10 bind the MAG gene BibTex
2019-08-16 R-HSA-9614773 MBP gene expression BibTex
2019-08-16 R-HSA-9614778 MAG gene expression BibTex
2019-08-16 R-HSA-9621410 HMGCR gene expression BibTex
2019-08-16 R-HSA-9621411 EGR2 and SREBF2(1-484) dimer bind HMGCR gene BibTex
2019-08-16 R-HSA-9618725 SOX10, EGR2 and NAB proteins bind the GJB1 promoter BibTex
2019-08-16 R-HSA-9613202 EGR1 and NAB co-repressors bind EGR1 gene BibTex
2019-08-16 R-HSA-9031624 ARC gene expression BibTex
2019-08-16 R-HSA-9031610 p-S133 CREB1, MEF2D and SRF bind the ARC gene BibTex
2019-08-16 R-MMU-9620391 Creb, Srf, and Mef2d bind the ARC gene BibTex
2019-08-16 R-HSA-9031616 EGR binds ARC gene BibTex
2019-08-16 R-MMU-9620402 Egr1, Egr3 bind the Arc promoter BibTex
2019-08-16 R-RNO-9620368 Egr1, Egr2 bind the Arc gene BibTex
2019-08-16 R-HSA-9031575 AP-1 binds ARC gene BibTex
2018-12-15 R-HSA-9625487 PTK2 autophosphorylates downstream of EGFR BibTex
2018-12-15 R-HSA-9625482 PTK2 binds activated EGFR BibTex
2018-12-15 R-HSA-9634584 Estrogen receptor binds IGF1R and SHC1 in response to estrogen BibTex
2018-12-15 R-HSA-9624272 MMPs cleave HB-EGF BibTex
2018-12-15 R-HSA-9632918 PRKCZ stimulates RAS nucleotide exchange in response to estrogen BibTex
2018-12-15 R-HSA-9632910 ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus BibTex
2018-12-15 R-HSA-9632906 PRKCZ recruits RAS in response to estrogen stimulation BibTex
2018-12-15 R-HSA-9632858 PRKCZ autophosphorylates downstream of estrogen stimulation BibTex
2018-12-15 R-HSA-9632182 PRMT1 methylates ESRs BibTex
2018-12-15 R-HSA-9633044 ESR binds STRN BibTex
2018-12-15 R-HSA-9632412 PTK2 is recruited to methylated ESR1 BibTex
2018-12-15 R-HSA-9625813 S1P binds S1PR3 in response to E2 stimulation BibTex
2018-12-15 R-HSA-9625814 SPHK1 phosphorylates sphingosine in response to E2 stimulation BibTex
2018-12-15 R-HSA-9623999 BCL gene expression downstream of ESR1 BibTex
2018-12-15 R-HSA-9625465 E2-mediated FOS gene expression BibTex
2018-12-15 R-HSA-9625479 SRF and ELK1 bind the FOS gene BibTex
2018-12-15 R-HSA-9624527 AKT-phosphorylated FOXO3 translocates to cytosol BibTex
2018-12-15 R-HSA-9624526 AKT phosphorylates FOXO3 downstream of ESR1 and EGFR BibTex
2018-12-15 R-HSA-9632873 p-S10 CDKN1B translocates to the cytosol BibTex
2018-12-15 R-HSA-9632868 CDKN1B is phosphorylated in response to estrogen BibTex
2018-12-15 R-HSA-9623341 p-S133 CREB1 dimer binds the CCND1 promoter BibTex
2018-12-15 R-HSA-9623355 ESR1-dependent CCND1 expression BibTex
2018-08-09 R-RNO-9616122 Egr2 and Sox10 bind the Mag gene BibTex
2018-06-05 R-HSA-9610152 Activated BRAF recruits MAP2Ks and MAPKs to the endosome BibTex
2018-06-05 R-HSA-9610166 p-T,Y MAPK dimers translocate to nucleus BibTex
2018-06-05 R-HSA-9610163 BRAF autophosphorylates downstream of RAP1 and NGF BibTex
2018-06-05 R-HSA-9610153 Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF BibTex
2018-06-05 R-HSA-9610156 MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF BibTex
2018-06-05 R-HSA-9610154 Dissociation of phosphorylated MAP2Ks and MAPKs BibTex
2018-02-23 R-HSA-9032751 Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 BibTex
2018-02-23 R-HSA-9038052 GREB1 binds ESR1:ESTG and co-activators BibTex
2018-02-23 R-HSA-9038163 ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators BibTex
2018-02-23 R-HSA-9038161 Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG BibTex
2018-02-23 R-HSA-9038029 27-hydroxysterol binds ESR1, ESR2 BibTex
2017-11-03 R-HSA-9029434 p-S363,S380,T573 RS6K translocates to the nucleus BibTex
2017-11-03 R-HSA-9027670 ESTG binding induces ESR depalmitoylation BibTex
2017-09-29 R-HSA-9023861 PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene BibTex
2017-09-29 R-HSA-9023860 Histone acetyltransferases are recruited to the TFF1 gene BibTex
2017-09-29 R-HSA-9023859 Estrogen-responsive TFF1 gene expression BibTex
2017-09-29 R-HSA-9012208 miR-26A and B bind to the 3'UTR of the KPNA2 mRNA BibTex
2017-09-29 R-HSA-9012209 Estrogen-responsive KPNA2 gene transcription BibTex
2017-09-29 R-HSA-9011966 Estrogen-responsive KDM4B gene expression BibTex
2017-09-29 R-HSA-9011961 GREB1 translation is negatively regulated by miR-26A and B BibTex
2017-09-29 R-HSA-9009378 Estrogen-responsive CCND1 gene expression BibTex
2017-09-29 R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter BibTex
2017-09-29 R-HSA-9009065 FOXA1 and GATA3 bind to CCND1 promoter BibTex
2017-09-29 R-HSA-8939201 ESR dimerizes BibTex
2017-09-29 R-HSA-8939203 HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex BibTex
2017-09-29 R-HSA-8939204 ESTG binds ESR1:chaperone complex BibTex
2017-09-29 R-HSA-8939205 ESTG translocates to the nucleus BibTex
2017-09-29 R-HSA-9709547 ESTG binds ESR2:chaperone complex BibTex
2017-09-29 R-HSA-9021660 PI3K binds membrane-associated estrogen receptors BibTex
2017-09-29 R-HSA-9021609 ESR-associated SRC autophosphorylates BibTex
2017-09-29 R-HSA-9021596 Membrane estrogen receptors bind SRC BibTex
2017-09-29 R-HSA-9021600 G-proteins dissociate from plasma-membrane estrogen receptors BibTex
2017-09-29 R-HSA-9021601 Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG BibTex
2017-09-29 R-HSA-9021170 Estrogen stimulates dimerization of plasma membrane estrogen receptors BibTex
2017-09-29 R-HSA-9021079 PalmS-ESRs:CAVs translocate to plasma membrane BibTex
2017-09-29 R-HSA-9021068 PalmS-ESRs bind CAVs BibTex
2017-09-29 R-HSA-9021072 ZDHHC7, ZDHHC21 palmitoylate ESR1 BibTex
2017-09-29 R-HSA-9018505 Estrogen-responsive EBAG9 gene expression BibTex
2017-09-29 R-HSA-9018503 ESR1:ESTG bind the EBAG9 5' region BibTex
2017-09-29 R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes BibTex
2017-09-29 R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen BibTex
2017-09-29 R-HSA-9011984 KDM1A is recruited to MYC and BCL2 genes BibTex
2017-09-29 R-HSA-9011983 Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes BibTex
2017-09-29 R-HSA-9023884 NCOA1 recruits EP300 to TGFA promoter BibTex
2017-09-29 R-HSA-9018497 Estrogen-responsive TFF3 gene expression BibTex
2017-09-29 R-HSA-9018499 ESR1:ESTG and EP300 are recruited to TFF3 promoter BibTex
2017-09-29 R-HSA-9018494 FOXA1 and GATA3 bind TFF genes BibTex
2017-09-29 R-HSA-9011971 Estrogen-responsive MYB gene expression BibTex
2017-09-29 R-HSA-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD BibTex
2017-09-29 R-HSA-9012315 ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene BibTex
2017-09-29 R-HSA-9011975 Estrogen-responsive MYC gene expression BibTex
2017-09-29 R-HSA-9011997 ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter BibTex
2017-09-29 R-HSA-9012000 NR5A2, ZNF217 and NCOA3 bind GREB1 promoter BibTex
2017-09-29 R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers BibTex
2017-09-29 R-HSA-9011952 ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers BibTex
2017-09-29 R-HSA-9012186 CHD1 translation is negatively regulated by miR-26A and B BibTex
2017-09-29 R-HSA-9011950 Estrogen-responsive GREB1 gene transcription BibTex
2017-09-29 R-HSA-9011958 miR-26A and B bind to the 3'UTR of the GREB1 mRNA BibTex
2017-09-29 R-HSA-9018334 Estrogen-responsive CXXC5 gene expresion BibTex
2017-09-29 R-HSA-9018325 ESR1:ESTG binds CXXC5 gene BibTex
2017-09-29 R-HSA-9012203 miR-26A and B bind to the 3'UTR of the CHD11 mRNA BibTex
2017-09-29 R-HSA-9012205 Estrogen-responsive CHD1 gene transcription BibTex
2017-09-29 R-HSA-9023840 HATs and coactivators are recruited to the CTSD gene BibTex
2017-09-29 R-HSA-9023845 ESR1:ESTG binds to proximal and distal regions of the CTSD promoter BibTex
2017-09-29 R-HSA-9011941 Estrogen-responsive BCL2 gene expression BibTex
2017-09-29 R-HSA-9012196 KPNA2 translation is negatively regulated by miR-26A and B BibTex
2017-09-29 R-HSA-9023846 Estrogen-responsive CTSD expression BibTex
2016-12-13 R-HSA-8956026 CUL9:RBX1 ubiquitinates BIRC5 BibTex
2016-12-13 R-HSA-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8956031 NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8956025 AcM-UBE2M transfers NEDD8 to CUL9:RBX1 BibTex
2016-12-13 R-HSA-8956050 NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 BibTex
2016-12-13 R-HSA-8956140 NEDD8 and UBD bind NUB1 and the 26S proteasome BibTex
2016-12-13 R-HSA-8956184 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates BibTex
2016-12-13 R-HSA-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 BibTex
2016-12-13 R-HSA-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus BibTex
2016-12-13 R-HSA-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8956103 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha BibTex
2016-12-13 R-HSA-8956106 VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha BibTex
2016-12-13 R-HSA-8956234 Translation of DCUN1D3 is inhibited by PUM2 BibTex
2016-12-13 R-HSA-8951766 Doubly neddylated UBA3:NAE1 binds AcM-UBE2F BibTex
2016-12-13 R-HSA-8951764 Transfer of NEDD8 to AcM-UBE2F BibTex
2016-12-13 R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8951644 Release of mature NEDD8 BibTex
2016-12-13 R-HSA-8951648 NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 BibTex
2016-12-13 R-HSA-8951656 NEDD8-UBA3:NAE1 binds a second NEDD8 BibTex
2016-12-13 R-HSA-8951751 Doubly neddylated UBA3:NAE1 binds AcM-UBE2M BibTex
2016-12-13 R-HSA-8951661 Transfer of NEDD8 to AcM-UBE2M BibTex
2016-12-13 R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases BibTex
2016-12-13 R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes BibTex
2016-12-13 R-HSA-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex BibTex
2016-12-13 R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes BibTex
2016-11-03 R-HSA-8944362 TCF/LEF:CTNNB1 bind canonical WNT target promoters BibTex
2016-11-03 R-HSA-8944352 TCF/LEF binds WNT promoters BibTex
2016-11-03 R-HSA-8944349 TLE tetramers bind TCF/LEF at WNT promoters BibTex
2016-08-04 R-HSA-8933446 Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling BibTex
2016-08-04 R-HSA-8933452 YWHAE dimer binds phosphorylated DENND1 proteins BibTex
2016-06-29 R-HSA-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 BibTex
2016-06-29 R-HSA-8877308 MADD exchanges GTP for GDP on RAB27 BibTex
2016-06-29 R-HSA-8876188 DENND4s exchange GTP for GDP on RAB10 BibTex
2016-06-29 R-HSA-8876190 RAB8 GEFs exchange GTP for GDP on RAB8 BibTex
2016-06-29 R-HSA-8877311 RAB31 GEFs exchange GTP for GDP on RAB31 BibTex
2016-06-29 R-HSA-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 BibTex
2016-06-29 R-HSA-8877813 DENND5A,B exchange GTP for GDP on RAB39 BibTex
2016-06-29 R-HSA-8875318 RAB3 GEFs exchange GTP for GDP on RAB3A BibTex
2016-06-29 R-HSA-8876616 DENND6A,B exchange GTP for GDP on RAB14 BibTex
2016-06-29 R-HSA-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7 BibTex
2016-06-29 R-HSA-8877612 DENND1s exchange GTP for GDP on RAB35 BibTex
2016-06-29 R-HSA-8877998 RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 BibTex
2016-06-29 R-HSA-8877760 HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 BibTex
2016-06-29 R-HSA-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6 BibTex
2016-06-29 R-HSA-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 BibTex
2016-06-29 R-HSA-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 BibTex
2016-06-29 R-HSA-8876446 p-ULK1 phosphorylates DENND3 BibTex
2016-06-29 R-HSA-8876454 DENND3 exchanges GTP for GDP on RAB12 BibTex
2016-06-29 R-HSA-8876615 RAB13 GEFs exchange GTP for GDP on RAB13 BibTex
2016-06-08 R-HSA-8870457 FarC-PTP4A2 binds RABGGTB BibTex
2016-06-08 R-HSA-8870461 RABGGTA and RABGGTB bind BibTex
2016-06-08 R-HSA-8870465 RGGT binds the RAB-binding subunit BibTex
2016-06-08 R-HSA-8870466 RGGT:CHM binds RABs BibTex
2016-06-08 R-HSA-8870469 RGGT geranylgeranylates RAB proteins BibTex
2016-05-13 R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 BibTex
2016-05-13 R-HSA-8871193 Dissociation of AAK1 and dephosphorylation of AP-2 mu2 BibTex
2016-05-13 R-HSA-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 BibTex
2016-05-11 R-HSA-8866268 ADBRK1,2 phosphorylate AVPR2 BibTex
2016-05-11 R-HSA-8863721 NEDD8-STON binds TOR1 hexamer and COP9 complex BibTex
2016-05-11 R-HSA-8863723 COP9 and TOR1 deneddylate STON2 BibTex
2016-05-11 R-HSA-8863727 STON2 is neddylated BibTex
2016-05-11 R-HSA-8866275 UBQLNs bind UIM-containing adaptor proteins BibTex
2016-05-11 R-HSA-8869438 Dissociation of clathrin-associated proteins BibTex
2016-05-11 R-HSA-8868071 Clathrin recruits PIK3C2A BibTex
2016-05-11 R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit BibTex
2016-05-11 R-HSA-8866279 Epsin family proteins bind ubiquitinated cargo BibTex
2016-05-11 R-HSA-8863463 STON2 binds SYT proteins BibTex
2016-05-11 R-HSA-8863718 AGFG1 binds VAMP7 BibTex
2016-05-11 R-HSA-8866277 AP-2 directly binds some endocytic cargo BibTex
2016-05-11 R-HSA-8863472 DAB2 binds LRP2 BibTex
2016-05-11 R-HSA-8863471 LDLR is bound by DAB2 and ARH BibTex
2016-05-11 R-HSA-8866269 ARRB bind GPCRs BibTex
2016-05-11 R-HSA-8867613 PICALM binds R-SNAREs BibTex
2016-05-11 R-HSA-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 BibTex
2016-05-11 R-HSA-8856808 Recruitment of AP-2 complex and clathrin BibTex
2016-05-11 R-HSA-8862280 FCHo proteins bind nascent clathrin-coated pit BibTex
2016-05-11 R-HSA-8866283 ARBB recruits GPCRs into clathrin-coated pits BibTex
2016-05-11 R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery BibTex
2016-05-11 R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit BibTex
2016-05-11 R-HSA-8868066 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 BibTex
2016-05-11 R-HSA-8868236 BAR domain proteins recruit dynamin BibTex
2016-05-11 R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit BibTex
2016-05-11 R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 BibTex
2016-05-11 R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P BibTex
2016-05-11 R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission BibTex
2016-05-11 R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle BibTex
2016-05-11 R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle BibTex
2016-05-11 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating BibTex
2016-04-19 R-HSA-8868118 MAPK12 phosphorylates PTPN3 BibTex
2016-04-05 R-HSA-8867047 PTPN3 dephosphorylates EPS15 BibTex
2016-04-05 R-HSA-8867041 EGFR phosphorylates EPS15 BibTex
2016-04-05 R-HSA-8867044 EGFR binds EPS15, EPN1, EPS15L1 BibTex
2016-04-02 R-HSA-8866858 CFTR F508del is degraded by the 26S proteasome BibTex
2016-04-02 R-HSA-8866857 CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation BibTex
2016-04-02 R-HSA-8866856 RNF5 and RNF185 ubiquitinate CFTR F508del BibTex
2016-04-02 R-HSA-8866854 VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol BibTex
2016-04-02 R-HSA-8866551 CFTR binds components of the ERAD machinery for ubiquitination and degradation BibTex
2016-04-02 R-HSA-8866546 RNF5 and RNF185 ubiquitinate misfolded CFTR BibTex
2016-04-02 R-HSA-8866851 CFTR transits to the plasma membrane BibTex
2016-04-02 R-HSA-8866858 CFTR F508del is degraded by the 26S proteasome BibTex
2016-04-02 R-HSA-8866854 VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol BibTex
2016-04-02 R-HSA-8866553 misfolded CFTR is degraded by the 26S proteasome BibTex
2016-04-02 R-HSA-8866542 VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol BibTex
2016-03-21 R-HSA-8867658 PTPN3 dephosphorylates MAPK12 BibTex
2016-03-21 R-HSA-8867654 PTPN3 binds p-T183,Y185 MAPK12 BibTex
2016-01-09 R-HSA-8853313 FGFR2 fusions autophosphorylate BibTex
2016-01-09 R-HSA-8853319 FGFR2 fusions dimerize BibTex
2016-01-09 R-HSA-8853323 Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3 BibTex
2016-01-09 R-HSA-8853307 FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange BibTex
2016-01-09 R-HSA-8853308 Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA BibTex
2016-01-09 R-HSA-8853314 Activated FGFR3 fusions:p-FRS2 bind GRB2-SOS1 BibTex
2016-01-09 R-HSA-8853309 Autocatalytic phosphorylation of FGFR3 fusions BibTex
2016-01-09 R-HSA-8853310 Activated FGFR3 fusions bind FRS2 BibTex
2016-01-09 R-HSA-8853315 Activated FGFR3 fusions phosphorylate FRS2 BibTex
2016-01-09 R-HSA-8853316 Activated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1 BibTex
2016-01-09 R-HSA-8853317 FGFR3 fusions dimerize BibTex
2016-01-09 R-HSA-8853322 Plasma membrane FGFR1 fusions dimerize BibTex
2016-01-09 R-HSA-8853325 Plasma membrane FGFR1 fusions autophosphorylate BibTex
2016-01-09 R-NUL-8853328 Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors BibTex
2016-01-09 R-HSA-8853320 FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling BibTex
2016-01-09 R-MMU-8851711 Aberrant alternative splicing generates a soluble disease variant FGFR2 IIIa TM BibTex
2016-01-09 R-HSA-8851710 Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant BibTex
2015-11-28 R-HSA-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP BibTex
2015-11-28 R-HSA-6814831 TBC1D20 binds RAB1:GTP BibTex
2015-11-09 R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane BibTex
2015-11-09 R-HSA-8847880 CYTH proteins bind ARF1:GTP BibTex
2015-11-09 R-HSA-8847883 CYTH proteins stimulate ARF1 GTPase activity BibTex
2015-11-09 R-HSA-8847887 RAB33B:GTP binds RIC1:RGP1 BibTex
2015-11-09 R-HSA-8847875 ARF1:GTP binds Golgin TRIP11 BibTex
2015-11-09 R-HSA-8849748 The COG complex binds RABs at the Golgi membrane BibTex
2015-11-09 R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering BibTex
2015-11-09 R-HSA-8847635 Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic BibTex
2015-11-09 R-HSA-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi BibTex
2015-11-09 R-HSA-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane BibTex
2015-11-09 R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER BibTex
2015-11-09 R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane BibTex
2015-11-09 R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi BibTex
2015-11-09 R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane BibTex
2015-11-09 R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules BibTex
2015-11-09 R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs BibTex
2015-11-09 R-HSA-6811427 COPI vesicle uncoating at the ER BibTex
2015-11-09 R-HSA-6811412 Active ARF recruits coatomer to the Golgi BibTex
2015-11-09 R-HSA-6811411 GBF1 recruits ARF:GDP to the Golgi BibTex
2015-11-09 R-HSA-6811414 GBF1 stimulates nucleotide exchange on ARF BibTex
2015-11-09 R-HSA-6811415 RAB:GTP recruits GBF1 to the Golgi membrane BibTex
2015-11-09 R-HSA-8850040 RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER BibTex
2015-11-09 R-HSA-8850041 RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 BibTex
2015-11-09 R-HSA-8849353 Dynein drives COPI-independent retrograde traffic from the Golgi to the ER BibTex
2015-11-09 R-HSA-8849345 LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine BibTex
2015-11-09 R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles BibTex
2015-11-09 R-HSA-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange BibTex
2015-11-09 R-HSA-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN BibTex
2015-11-09 R-HSA-6814086 ARFRP1 recruits ARL1 to the TGN BibTex
2015-11-09 R-HSA-6814088 SYS1 binds AcM-ARFRP1 BibTex
2015-11-09 R-HSA-6814090 NatC acetylates ARFFRP1 BibTex
2015-11-09 R-SCE-6814089 NatC acetylates ARL3 BibTex
2015-11-09 R-HSA-6814671 Fusion of late-endosome derived vesicles at the TGN BibTex
2015-11-09 R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins BibTex
2015-11-09 R-HSA-6814670 ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation BibTex
2015-11-09 R-HSA-6814675 RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN BibTex
2015-11-09 R-HSA-6814094 ARL1:GTP binds ARFIP2 BibTex
2015-11-09 R-HSA-8847534 RAB43 hydrolyses GTP BibTex
2015-11-09 R-HSA-8847537 RAB43:GTP binds USP8NL BibTex
2015-11-09 R-HSA-6814091 ARL1 recruits TGN Golgin homodimers BibTex
2015-11-09 R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN BibTex
2015-11-09 R-HSA-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN BibTex
2015-11-09 R-HSA-6814096 ARL1:GTP binds SCOC BibTex
2015-11-09 R-HSA-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN BibTex
2015-11-09 R-HSA-6814682 Fusion of early-endosome derived vesicles at the TGN BibTex
2015-11-09 R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN BibTex
2015-11-09 R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex BibTex
2015-11-09 R-HSA-8849348 RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo BibTex
2015-11-09 R-HSA-8848484 PLA2s hydrolyze phospholipids at the Golgi membrane BibTex
2015-11-03 R-HSA-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi BibTex
2015-11-03 R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin BibTex
2015-11-03 R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex BibTex
2015-11-03 R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle BibTex
2015-11-03 R-HSA-6809010 COPI vesicle uncoating BibTex
2015-11-03 R-HSA-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs BibTex
2015-10-07 R-HSA-6803836 FGFR2b-specific alternative splicing produces FGFR2b transcript BibTex
2015-10-07 R-HSA-6803838 FGFR2c-specific alternative splicing produces FGFR2c transcript BibTex
2015-10-05 R-HSA-6803527 ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression BibTex
2015-10-05 R-HSA-6803523 PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA BibTex
2015-09-02 R-HSA-6807864 RAB1:GTP recruits GBF1 to the ERGIC BibTex
2015-09-02 R-HSA-6807866 GBF1 recruits ARF:GDP to the ERGIC BibTex
2015-09-02 R-HSA-6807868 GBF1 stimulates ARF nucleotide exchange BibTex
2015-09-02 R-HSA-6807872 Active ARF recruits coatomer BibTex
2015-09-02 R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex BibTex
2015-09-02 R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity BibTex
2015-08-10 R-HSA-6802932 Dissociation of BRAF/RAF fusion complex BibTex
2015-08-10 R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated BibTex
2015-08-10 R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs BibTex
2015-08-10 R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks BibTex
2015-08-10 R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers BibTex
2015-08-10 R-HSA-6802837 Loss-of-function NF1 variants don't stimulate RAS GTPase activity BibTex
2015-08-10 R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes BibTex
2015-08-10 R-HSA-6803230 Dissociation of moderate activity BRAF complexes BibTex
2015-08-10 R-HSA-6803227 Dissociation of high activity BRAF complexes BibTex
2015-08-10 R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex BibTex
2015-05-21 R-HSA-5694436 MIA2 and MIA3 dissociate from procollagen VII vesicle BibTex
2015-05-18 R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF BibTex
2015-05-18 R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs BibTex
2015-05-18 R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks BibTex
2015-05-18 R-HSA-6802937 Inactive BRAF mutants bind mutant RAS:GTP BibTex
2015-05-18 R-HSA-8936731 Inactive BRAF mutants:mutant RAS:GTP bind RAF1 BibTex
2015-05-18 R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants BibTex
2015-05-18 R-HSA-8936676 Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize BibTex
2015-05-18 R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants BibTex
2015-05-18 R-HSA-6802915 Moderate kinase activity BRAF mutants bind RAS:GTP BibTex
2015-05-18 R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants BibTex
2015-05-18 R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs BibTex
2015-05-18 R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks BibTex
2015-05-18 R-HSA-6802938 Inhibitors bind and inhibit highly active BRAF mutants BibTex
2015-05-18 R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants BibTex
2015-05-18 R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks BibTex
2015-05-18 R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs BibTex
2015-05-18 R-HSA-6802930 Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance BibTex
2015-05-18 R-HSA-6803240 Homo- or heterodimerization of RAF downstream of mutant RAS BibTex
2015-05-18 R-HSA-6802908 RAS mutants bind inactive RAF BibTex
2015-05-18 R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS BibTex
2015-05-18 R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs BibTex
2015-05-18 R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks BibTex
2015-05-18 R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS BibTex
2015-05-18 R-HSA-6802834 RAS GTPase mutants don't hydrolyze GTP BibTex
2015-04-18 R-HSA-5694427 MIA3 binds procollagen VII BibTex
2015-04-18 R-HSA-5694410 TMED2:TMED10 tetramer binds GPI anchored proteins BibTex
2015-04-18 R-HSA-5694445 CNIH1 binds TFGA and AREG precursors BibTex
2015-04-18 R-HSA-5694413 SEC4C,D bind GOSR2 and STX5 BibTex
2015-04-18 R-HSA-5694431 Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors BibTex
2015-04-18 R-HSA-5694415 SEC24A,B:SEC23A bind SEC22B BibTex
2015-04-18 R-HSA-5694435 MIA2 and MIA3 load procollagen VII into COPII vesicles BibTex
2015-04-18 R-HSA-5694428 LMAN family proteins bind glycosylated cargo BibTex
2015-04-18 R-HSA-5694433 MIA2 binds PREB BibTex
2015-04-18 R-HSA-5694442 CNIH2,3 bind GRIA1 BibTex
2015-04-15 R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE BibTex
2015-04-15 R-HSA-5694423 NSF and SNAPs bind cis-SNARE complex BibTex
2015-04-06 R-HSA-5687112 MAPK6 is degraded by the 26S proteasome BibTex
2015-04-03 R-HSA-5687097 p-S857 NCOA3 binds ETV4 BibTex
2015-04-03 R-HSA-5687090 p-S MAPK6 phosphorylates NCOA3 BibTex
2015-04-03 R-HSA-5687088 PKA phosphorylates MAPKAPK5 BibTex
2015-04-03 R-HSA-5687123 p-S115 MAPKAPK5 translocates to the cytosol BibTex
2015-04-03 R-HSA-5687099 p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter BibTex
2015-03-30 R-HSA-5687083 MYC binds MAPKAPK5 gene BibTex
2015-03-30 R-HSA-5687086 PAK1,2,3 phosphorylates MAPK6,4 BibTex
2015-03-30 R-HSA-5687079 IGF2BP1 binds MAPK4 mRNA BibTex
2015-03-30 R-HSA-5687101 p-T182 MAPKAPK5 phosphorylates FOXO3 BibTex
2015-03-30 R-HSA-5687103 FOXO3 regulates MIR34B,C expression BibTex
2015-03-30 R-HSA-5687095 p-S215 FOXO3 binds MIR34B and C gene BibTex
2015-03-30 R-HSA-5687113 MYC mRNA translation is negatively regulated by miR-34B and C BibTex
2015-03-30 R-HSA-5687081 MAPK6 is ubiquitinated at the N-terminal BibTex
2015-03-30 R-HSA-5687115 MYC positively regulates MAPKAPK5 gene expression BibTex
2015-03-30 R-HSA-5687105 IGF2BP1 represses translation of MAPK4 mRNA BibTex
2015-03-30 R-HSA-5687109 MAPK4,6 translocate to the cytoplasm BibTex
2015-03-30 R-HSA-5687121 p-S MAPKAPK5 phosphorylates HSPB1 BibTex
2015-03-30 R-HSA-5687107 MAPK4,6 translocate to nucleus BibTex
2015-03-30 R-HSA-5687091 p-S MAPK6,4 binds MAPKAPK5 BibTex
2015-03-30 R-HSA-5687094 p-S MAPK6,4 phosphorylate MAPKAPK5 BibTex
2015-03-30 R-HSA-5687120 p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol BibTex
2015-03-30 R-HSA-5687126 p-S215 FOXO3 translocates to the nucleus BibTex
2015-03-30 R-HSA-5694446 BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle BibTex
2015-03-28 R-HSA-5694522 Inner coat assembly and cargo binding BibTex
2015-03-16 R-HSA-5694421 PP6 dephosphorylates SEC24 BibTex
2015-03-16 R-HSA-5694417 SEC16 complex binds SAR1B:GTP:SEC23:SEC24 BibTex
2015-03-16 R-HSA-5694439 COPII coat binds TRAPPCII and RAB1:GDP BibTex
2015-03-16 R-HSA-5694409 Nucleotide exchange on RAB1 BibTex
2015-03-16 R-HSA-5694441 CSNK1D phosphorylates SEC23 BibTex
2015-03-16 R-HSA-5694418 RAB1:GTP binds USO1 and GORASP1:GOLGA2 BibTex
2015-02-16 R-HSA-5675417 PEBP1 binds activated RAF1 BibTex
2015-02-16 R-HSA-5675431 PP2A dephosphorylates RAF1 BibTex
2015-02-16 R-HSA-5675433 PP5 dephosphorylates RAF1 S338 BibTex
2015-02-15 R-HSA-5675376 Cytosolic DUSPs dephosphorylate MAPKs BibTex
2015-02-15 R-HSA-5675373 Nuclear DUSPs dephosphorylate MAPKs BibTex
2015-02-12 R-HSA-5672980 Dissociation of RAS:RAF complex BibTex
2015-02-12 R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange BibTex
2015-02-12 R-HSA-5675206 PEA15 binds MAPK monomers and dimers BibTex
2015-02-12 R-HSA-5675194 Activated MAPK phosphorylates RAF1 BibTex
2015-02-12 R-HSA-5675198 Activated MAPKs phosphorylate BRAF BibTex
2015-02-12 R-HSA-5674496 Activated MAPKs phosphorylate MAP2K1 BibTex
2015-02-11 R-HSA-5674373 MAP2Ks phosphorylate MAPK at the Golgi membrane BibTex
2015-02-11 R-HSA-5674366 IL17RD binds p-2S MAP2Ks and MAPKs BibTex
2015-02-11 R-HSA-5674385 p-T,Y MAPKs dimerize BibTex
2015-02-11 R-HSA-5674387 Phosphorylated MAPKs translocate into the nucleus BibTex
2015-02-11 R-HSA-5674140 PAQR3 binds inactive RAFs BibTex
2015-02-10 R-HSA-5674130 MAP2Ks and MAPKs are phosphorylated at the endosome membrane BibTex
2015-02-10 R-HSA-5674132 WDR83:LAMTOR2:LAMTOR3 binds MAPK components BibTex
2015-02-06 R-HSA-5674019 BRAP binds KSR1:MARK3 BibTex
2015-02-06 R-HSA-5674022 BRAP autoubiquitinates BibTex
2015-02-06 R-HSA-5674018 BRAP binds RAS:GTP BibTex
2015-02-06 R-HSA-5672957 PP2A dephosphorylates KSR1 BibTex
2014-12-18 R-HSA-5672960 YWHAB dimer dissociates from dephosphorylated RAF BibTex
2014-12-18 R-HSA-5672961 PP2A dephosphorylates inactive RAFs BibTex
2014-12-18 R-HSA-5672951 Inactive RAFs bind YWHAB BibTex
2014-12-18 R-HSA-5672948 MARK3 phosphorylates KSR1 BibTex
2014-12-18 R-HSA-5672954 p-S311,S406 KSR1:MARK3 binds YWHAB dimer BibTex
2014-12-18 R-HSA-5672958 YWHAB dimer dissociates from KSR1:MARK3 BibTex
2014-12-18 R-HSA-5672950 "Activator" RAF:YWHAB dimer binds RAS:GTP BibTex
2014-12-18 R-HSA-5672966 RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers BibTex
2014-12-18 R-HSA-5672969 Phosphorylation of RAF BibTex
2014-12-18 R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex BibTex
2014-12-18 R-HSA-5672978 RAF phosphorylates MAP2K dimer BibTex
2014-12-18 R-HSA-5672973 MAP2Ks phosphorylate MAPKs BibTex
2014-12-11 R-HSA-5658430 NF1 is degraded by the proteasome BibTex
2014-12-11 R-HSA-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 BibTex
2014-12-11 R-HSA-5658438 SPRED dimer binds NF1 BibTex
2014-12-10 R-HSA-8981355 RASA1 binds RAS:GTP BibTex
2014-12-10 R-HSA-8981353 RASA1 stimulates RAS GTPase activity BibTex
2014-12-10 R-HSA-5658231 RAS GAPs stimulate RAS GTPase activity BibTex
2014-12-10 R-HSA-5658435 RAS GAPs bind RAS:GTP BibTex
2014-12-08 R-HSA-5656064 Activated FGFR1 binds FLRT1,2,3 BibTex
2014-12-08 R-HSA-5656070 FGFBPs bind FGFs BibTex
2014-12-02 R-HSA-5654515 KAL1 binds HS BibTex
2014-12-02 R-HSA-5654514 KAL1 binds FGFR1c BibTex
2014-11-20 R-HSA-5654510 FGFRL1 binds SPRED1/2 BibTex
2014-11-20 R-HSA-5654511 FGFRL1 dimer binds FGFs BibTex
2014-11-07 R-HSA-5635868 ub-GLI is degraded by the proteasome BibTex
2014-11-07 R-HSA-445448 HHIP binds Hedgehog BibTex
2014-11-07 R-HSA-5635854 GLI2,3 are degraded by the proteasome BibTex
2014-10-31 R-HSA-5635850 GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters BibTex
2014-10-31 R-HSA-5635848 GLI proteins bind PTCH1 gene BibTex
2014-10-31 R-HSA-5635845 GLI proteins bind CDC73 BibTex
2014-10-31 R-HSA-5635102 GPR161 is internalized BibTex
2014-10-31 R-HSA-5635846 GLI proteins bind GLI1 gene BibTex
2014-10-31 R-HSA-5635853 Hh-dependent expression of GLI1 gene BibTex
2014-10-31 R-HSA-5635861 NUMB:ITCH binds GLI1 BibTex
2014-10-31 R-HSA-5635865 SMURF1/2 dissociates from ub-PTCH1 BibTex
2014-10-31 R-HSA-5635855 phosphorylated GLI proteins bind SPOP:CUL3:RBX1 BibTex
2014-10-31 R-HSA-5635856 SPOP:CUL3:RBX1 ubiquitinates GLI2,3 BibTex
2014-10-31 R-HSA-5635839 ULK3:SUFU dissociates BibTex
2014-10-31 R-HSA-5635860 GLI:SUFU translocates to the ciliary tip in response to Hh signaling BibTex
2014-10-31 R-HSA-5635859 GLI:SUFU dissociates BibTex
2014-10-31 R-HSA-5635842 ULK3 phosphorylates GLI BibTex
2014-10-31 R-HSA-5635843 GLI translocates to the nucleus BibTex
2014-10-31 R-HSA-5635841 GLI proteins are phosphorylated BibTex
2014-10-31 R-HSA-5635864 NUMB:ITCH ubiquitinates GLI1 BibTex
2014-10-30 R-HSA-5638016 RP2:ARL3:GDP:UNC119B dissociates BibTex
2014-10-30 R-HSA-5638004 RP2 binds ARL3:GTP:UNC119B BibTex
2014-10-30 R-HSA-5638012 PDE6D dissociates from ARL13B:INPP5E BibTex
2014-10-30 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body BibTex
2014-10-30 R-HSA-5638014 RAB11A:GTP-containing Golgi vesicles recruit RAB3IP BibTex
2014-10-28 R-HSA-5633051 EFCAB7:IQCE binds EVC2:EVC BibTex
2014-10-28 R-HSA-5633040 CSNK1A1 and ADRBK1 dissociate from p-SMO dimer BibTex
2014-10-28 R-HSA-5632674 ADRBK1 binds phosphorylated SMO dimer BibTex
2014-10-28 R-MMU-5633169 Evc2:Evc binds Smo BibTex
2014-10-24 R-MMU-5632665 Adrbk1 phosphorylates Smo dimer BibTex
2014-10-24 R-MMU-5632663 Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1 BibTex
2014-10-24 R-MMU-5632661 Csnk1a1 phosphorylates Smo dimer BibTex
2014-10-24 R-HSA-5632671 CSNK1A1 binds SMO dimer BibTex
2014-10-24 R-HSA-5632670 CSNK1A1 phosphorylates SMO dimer BibTex
2014-10-24 R-HSA-5632672 ADRBK1 phosphorylates SMO dimer BibTex
2014-10-24 R-HSA-5632679 EVC2:EVC binds p-SMO BibTex
2014-10-24 R-MMU-5632658 Csnk1a1 binds Smo dimer BibTex
2014-10-20 R-HSA-5632649 Hh-Npp binds GAS1 and PTCH BibTex
2014-10-20 R-HSA-5632652 Hh-Npp binds CDON and PTCH BibTex
2014-10-20 R-MMU-5632654 Shh binds Boc:Ptch1 BibTex
2014-10-20 R-HSA-5632653 Hh-Npp binds BOC:PTCH1 BibTex
2014-10-20 R-MMU-5632657 Smo dimer binds Arrb and Kif3a BibTex
2014-10-20 R-HSA-5632667 SMO dimer binds ARRB and KIF3A BibTex
2014-10-20 R-MMU-5632644 Smurf1/2 ubiquitinates Ptch1 BibTex
2014-10-20 R-MMU-5632642 Smurf1/2 bind Ptch1 BibTex
2014-10-20 R-HSA-5632646 SMURF1/2 bind PTCH1 BibTex
2014-10-20 R-HSA-5632648 SMURF1/2 ubiquitinates PTCH1 BibTex
2014-10-20 R-HSA-5632677 PTCH is internalized BibTex
2014-10-09 R-HSA-5626681 Recruitment of transition zone proteins BibTex
2014-10-09 R-HSA-5626699 MARK4 binds ODF2 in the centriole BibTex
2014-10-04 R-HSA-5626227 CP110 and CEP97 dissociate from the centriole BibTex
2014-10-04 R-HSA-5626220 C2CD3 binds the mother centriole BibTex
2014-10-04 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole BibTex
2014-10-04 R-HSA-5626228 The distal appendage proteins recruit TTBK2 BibTex
2014-10-04 R-HSA-5625416 Anterograde IFT BibTex
2014-09-30 R-HSA-5625421 The anterograde IFT train dissociates BibTex
2014-09-30 R-HSA-5625426 Retrograde IFT BibTex
2014-09-30 R-HSA-5625424 The retrograde IFT train dissociates BibTex
2014-09-19 R-HSA-5624954 INPP5E translocates to the primary cilium BibTex
2014-09-19 R-HSA-5624953 ARL13B binds INPP5E BibTex
2014-09-19 R-HSA-5624956 PDE6D binds INPP5E BibTex
2014-09-19 R-HSA-5624952 Assembly of the retrograde IFT train BibTex
2014-09-19 R-HSA-5624951 TNPO1 binds KIF17 dimer BibTex
2014-09-19 R-HSA-5624948 KIF17 enters the cilium BibTex
2014-09-19 R-HSA-5624949 Assembly of the anterograde IFT train BibTex
2014-09-19 R-HSA-5624129 LZTFL1 binds the BBSome and prevents its traffic to the cilium BibTex
2014-09-15 R-HSA-5624130 Myristoylated NPHP3 translocates into the ciliary membrane BibTex
2014-09-15 R-HSA-5638007 RP2 activates the GTPase activity of ARL3 BibTex
2014-09-15 R-HSA-5638006 ARL3 hydrolyzes GTP BibTex
2014-09-15 R-HSA-5624131 UNC119B binds myristoylated proteins BibTex
2014-09-15 R-HSA-5624132 UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium BibTex
2014-09-15 R-HSA-5624133 ARL3:GTP binds the UNC119B complex BibTex
2014-09-15 R-HSA-5624126 ARL6:GTP and the BBSome bind ciliary cargo BibTex
2014-09-15 R-HSA-5624127 ARL6:GTP and the BBSome target cargo to the primary cilium BibTex
2014-09-15 R-HSA-5624125 Formation of the BBSome BibTex
2014-09-12 R-HSA-5623508 GBF1 stimulates nucleotide exchange on ARF4 BibTex
2014-08-28 R-HSA-5623527 VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane BibTex
2014-08-28 R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex BibTex
2014-08-28 R-NUL-5623510 Asap1 binds the FR motif of Rho BibTex
2014-08-28 R-HSA-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex BibTex
2014-08-28 R-HSA-5623513 ASAP1 stimulates GTPase activity of ARF4 BibTex
2014-08-28 R-HSA-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex BibTex
2014-08-28 R-HSA-5623521 RAB3IP stimulates nucleotide exchange on RAB8A BibTex
2014-08-28 R-HSA-5623525 Cargo-carrying vesicles bud from the TGN BibTex
2014-08-28 R-HSA-5620918 ASAP1 dimer binds membrane proteins BibTex
2014-08-22 R-HSA-5620914 ARF4:GTP binds VxPx-motifs of membrane proteins BibTex
2014-08-15 R-HSA-5618331 HDAC6 deacetylates microtubules BibTex
2014-08-15 R-HSA-5618328 ATAT acetylates microtubules BibTex
2014-08-13 R-MMU-5617824 assembly of IftB complex BibTex
2014-08-13 R-HSA-5617825 TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi BibTex
2014-08-07 R-HSA-5617815 BBSome binds RAB3IP BibTex
2014-08-07 R-MMU-5617819 Traf3ip1 binds Ift20 BibTex
2014-08-07 R-HSA-5617820 Assembly of IFT B complex BibTex
2014-08-07 R-HSA-5617828 TRIP11:IFT20 dissociates BibTex
2014-08-07 R-HSA-5617829 Assembly of IFT A complex BibTex
2014-08-07 R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A BibTex
2014-08-07 R-HSA-5632668 SMO translocates to the cilium BibTex
2014-07-23 R-HSA-5612510 Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling BibTex
2014-07-23 R-HSA-5612508 GLI3R binds the PTCH1 promoter BibTex
2014-07-23 R-HSA-5617408 GLI3R binds the GLI1 promoter BibTex
2014-07-23 R-HSA-5617412 Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling BibTex
2014-07-23 R-HSA-5617410 GLI3R binds the GLI2 promoter BibTex
2014-07-23 R-HSA-5617413 Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling BibTex
2014-07-17 R-HSA-5610763 PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal BibTex
2014-07-17 R-HSA-5610767 The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip BibTex
2014-07-17 R-HSA-5610766 The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base BibTex
2014-07-17 R-HSA-5610726 The IFT-A complex recruits TULP3 BibTex
2014-07-17 R-HSA-5610725 TULP3 is required for GPR161 localization in the cilium BibTex
2014-07-17 R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner BibTex
2014-07-17 R-HSA-5610749 cAMP dissociates PKA, promoting GLI processing BibTex
2014-05-16 R-HSA-5483238 Hh processing variants are ubiquitinated BibTex
2014-05-13 R-HSA-5483229 HHAT G287V doesn't palmitoylate Hh-Np BibTex
2014-05-08 R-HSA-5610733 KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules BibTex
2014-05-08 R-NUL-5610751 Gli2is degraded by the proteasome BibTex
2014-05-08 R-NUL-5610711 SCF(beta-TrCP) ubiquitinates p-Gli2 BibTex
2014-05-08 R-NUL-5610714 GSK3 phosphorylates p-Gli2 BibTex
2014-05-08 R-NUL-5610715 CK1 phosphorylates p-Gli2 BibTex
2014-05-08 R-MMU-5610710 Pka phosphorylates Gli2 BibTex
2014-05-08 R-HSA-5610717 PKA phosphorylates GLI2 BibTex
2014-05-08 R-HSA-5610718 CK1 phosphorylates p-GLI2 BibTex
2014-05-08 R-HSA-5610730 GSK3 phosphorylates p-GLI2 BibTex
2014-05-08 R-HSA-5610745 SCF(beta-TrCP) ubiquitinates p-GLI2 BibTex
2014-05-08 R-HSA-5610757 GLI2 is degraded by the proteasome BibTex
2014-05-08 R-HSA-5610760 GLI1 is degraded by the proteasome after ubiquitination by ITCH BibTex
2014-05-08 R-HSA-5610737 NUMB:ITCH bind and ubiquitnate GLI1 BibTex
2014-05-08 R-HSA-5610758 GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP BibTex
2014-05-08 R-HSA-5610742 SCF(beta-TrCP) ubiquitinates p-GLI1 BibTex
2014-05-08 R-NUL-5610740 Pka phosphorylates GLI1 BibTex
2014-05-08 R-HSA-5610741 PKA phosphorylates GLI1 BibTex
2014-05-08 R-HSA-5610735 NUMB binds ITCH BibTex
2014-05-08 R-HSA-5610723 GLI proteins bind SUFU BibTex
2014-05-08 R-HSA-5610720 PKA phosphorylates GLI3 BibTex
2014-05-08 R-HSA-5610722 CK1 phosphorylates p-GLI3 BibTex
2014-05-08 R-HSA-5610732 GSK3 phosphorylates p-GLI3 BibTex
2014-05-08 R-HSA-5610746 SCF(beta-TrCP) ubiquitinates p-GLI3 BibTex
2014-05-08 R-HSA-5610754 GLI3 is partially degraded by the proteasome to yield the GLI3 repressor BibTex
2014-05-08 R-HSA-5610752 GLI3R translocates to the nucleus BibTex
2014-04-21 R-HSA-5387386 Hh processing variants are recruited to SEL1:SYVN at the ER membrane BibTex
2014-04-16 R-NUL-5362792 Shh is released from the plasma membrane by ADAM17-mediated cleavage BibTex
2014-04-16 R-HSA-5362793 Hh-Np is cleaved by ADAM17 to promote ligand shedding BibTex
2014-04-08 R-HSA-5362427 Hh-Np binds GPC5 BibTex
2014-04-08 R-HSA-5362553 NOTUM releases Hh-Np:GPC5 from the plasma membrane BibTex
2014-04-08 R-NUL-5362406 mouse Disp2 binds SHH N-terminal fragment BibTex
2014-04-08 R-HSA-5362422 Hh-Np binds to DISP2 BibTex
2014-04-08 R-HSA-5362551 Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling BibTex
2014-04-08 R-HSA-5362549 Hh-Np traffics to the plasma membrane BibTex
2014-04-08 R-HSA-5362441 C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane BibTex
2014-04-08 R-HSA-5362412 SYVN1 ubiquitinates Hh C-terminal fragments BibTex
2014-04-08 R-HSA-5362459 VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol BibTex
2014-04-08 R-HSA-5387389 Hh processing variants are translocated to the cytosol in a VCP-dependent manner BibTex
2014-04-03 R-HSA-4827388 CTNNB1 S45 mutants aren't phosphorylated by CK1alpha BibTex
2014-04-03 R-HSA-5334052 TFC7L2 mutants don't bind CTBP BibTex
2014-03-29 R-HSA-5362437 C-terminal Hh fragments are bound by lectins BibTex
2014-03-29 R-HSA-5362448 Hh C-terminal fragments are degraded by the proteasome BibTex
2014-03-29 R-HSA-5362386 Glycosylation of Hh BibTex
2014-03-29 R-HSA-5362450 Hh processing variants bind lectins BibTex
2014-03-29 R-HSA-5387392 processing defective Hh variants are degraded by the proteasome BibTex
2014-03-28 R-HSA-5358460 HPE SHH variants don't undergo autoproteolytic cleavage BibTex
2014-03-24 R-HSA-5358343 HHAT palmitoylates Hh N-terminal fragment BibTex
2014-03-24 R-HSA-5358336 P4HB forms mixed disulphides with Hh precursors BibTex
2014-03-24 R-HSA-5358340 Autoproteolytic cleavage of Hh precursors BibTex
2014-03-11 R-HSA-5340587 RNF43 frameshift mutants show enhanced WNT siganling BibTex
2014-03-11 R-HSA-5340560 PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion BibTex
2014-02-22 R-HSA-5339713 Misspliced GSK3beta mutants stabilize beta-catenin levels BibTex
2014-02-22 R-HSA-5339711 misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling BibTex
2014-02-18 R-HSA-5334050 TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes BibTex
2014-02-10 R-HSA-5323545 Canonical WNT signaling through the atypical receptor RYK BibTex
2014-02-10 R-HSA-5323526 FRAT proteins bind GSK3beta BibTex
2014-02-06 R-HSA-5262606 XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling BibTex
2014-01-23 R-HSA-5251562 Deletions in the AXIN1 gene prevent expression of AXIN1 protein BibTex
2014-01-23 R-HSA-5251559 Deletions of the AMER1 gene prevent expression of AMER1 protein BibTex
2014-01-23 R-HSA-5251557 Expression of AMER1 gene BibTex
2014-01-23 R-HSA-5251555 Expression of AXIN1 gene BibTex
2014-01-17 R-HSA-5246696 APC truncation mutants are not K63 polyubiquitinated BibTex
2014-01-17 R-HSA-5246693 APC is K63-polyubiquitinated BibTex
2014-01-17 R-HSA-5229343 AXIN is phosphorylated in the destruction complex BibTex
2014-01-14 R-HSA-5229348 Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes BibTex
2013-11-12 R-HSA-5099886 WNT5A binding to FZD promotes PRICKLE1 degradation BibTex
2013-11-01 R-HSA-4839734 AXIN mutants destabilize the destruction complex BibTex
2013-10-30 R-HSA-4839746 Truncated AMER1 mutants destabilize the destruction complex BibTex
2013-10-30 R-HSA-4839635 CTNNB1 S37 mutants aren't phosphorylated by GSK3beta BibTex
2013-10-30 R-HSA-4839634 CTNNB1 S33 mutants aren't phosphorylated by GSK3beta BibTex
2013-10-30 R-HSA-4839638 CTNNB1 T41 mutants aren't phosphorylated by GSK3beta BibTex
2013-10-08 R-HSA-4791278 APC truncation mutants have impaired AXIN binding BibTex
2013-09-28 R-NUL-4649029 Gro binds Aes BibTex
2013-09-28 R-HSA-4649028 TLE forms non-functional complexes with AES BibTex
2013-09-24 R-HSA-4641231 TLE recruits HDAC1 to WNT promoters BibTex
2013-09-24 R-HSA-4641229 TLE oligomerizes BibTex
2013-09-24 R-HSA-4641260 Ubiquitinated DVL1 is degraded by the proteasome BibTex
2013-09-24 R-HSA-4641147 DACT1 binds DVL2 BibTex
2013-09-24 R-HSA-4641159 DVL1 is ubiquitinated by HECW1 BibTex
2013-09-24 R-HSA-4641155 DVL1 is bound by the HECT ubiquitin ligase HECW1 BibTex
2013-09-24 R-HSA-4641256 Ubiquitinated AXIN is degraded by the proteasome BibTex
2013-09-24 R-HSA-4641129 AXIN is ubiquitinated by SMURF2 BibTex
2013-09-24 R-HSA-4641134 SMURF2 binds AXIN BibTex
2013-09-24 R-HSA-4641246 ZNRF3 autoubiquitinates to promote its internalization BibTex
2013-09-24 R-HSA-4641205 RSPO:LGR binds ZNRF3 BibTex
2013-09-24 R-HSA-4641206 RSPOs bind LGRs BibTex
2013-09-24 R-HSA-4641236 USP8 deubiquitinates FZD to potentiate WNT signaling BibTex
2013-09-24 R-HSA-4641253 ZNRF3 ubiquitinates FZD to promote its downregulation BibTex
2013-09-24 R-HSA-4641249 ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex BibTex
2013-09-19 R-HSA-4608852 SMURF1/2 ubiquitinates PRICKLE1 BibTex
2013-09-19 R-HSA-4608855 PRICKLE1 is degraded by the proteasome BibTex
2013-09-19 R-HSA-4608825 DVL2 is phosphorylated after WNT5A binding to FZD BibTex
2013-09-19 R-HSA-4608854 SMURF1/2 are recruited to the DVL2:PARD6A complex BibTex
2013-09-14 R-MMU-4608842 Fz3 asymmetric membrane localization depends on direct interaction with Vangl2 BibTex
2013-09-14 R-MMU-4608838 Scrib is required for Vangl2 asymmetric membrane localization in mouse BibTex
2013-09-14 R-HSA-4608862 SCRIB is required for asymmetric membrane localization of VANGL2 BibTex
2013-09-14 R-HSA-4608866 VANGL2 is required for asymmetric membrane localization of FZD3 BibTex
2013-09-14 R-XLA-4568832 Wnt11 binds Fzd7 to regulate convergent extension in Xenopus BibTex
2013-09-14 R-HSA-4551465 Translocation of NFATC1:CaN:CaM to nucleus BibTex
2013-09-12 R-MMU-4551572 Vangl2 is phosphorylated in response to Wnt5a BibTex
2013-09-12 R-HSA-4551570 VANGL2 is phosphorylated in response to WNT5A BibTex
2013-09-12 R-MMU-4551566 Wnt5a binds Ror2 and Vangl2 BibTex
2013-09-12 R-HSA-4551571 WNT5A binds ROR2 and VANGL2 BibTex
2013-09-06 R-NUL-4551554 Wnt5a binds RYK and VANGL2 BibTex
2013-09-06 R-HSA-4551555 RYK binds WNT5A and VANGL2 BibTex
2013-09-04 R-HSA-4551451 Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling BibTex
2013-09-04 R-MMU-4551446 Prkg is activated upon cGMP binding BibTex
2013-09-04 R-HSA-4551453 PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling BibTex
2013-09-03 R-NUL-4551534 RFzd binds trimeric G-proteins BibTex
2013-08-29 R-HSA-4518575 miR-92b binds 3'UTR of NLK mRNA BibTex
2013-08-29 R-HSA-4411365 Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF BibTex
2013-08-29 R-HSA-4518585 NLK mRNA translation controlled by miR-92b BibTex
2013-08-29 R-HSA-4332390 Translocation and activation of PKC alpha in response to WNT signaling BibTex
2013-08-29 R-HSA-4420052 Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT BibTex
2013-08-24 R-HSA-4411372 TCF/LEF:CTNNB1 promote transcription of AXIN2 BibTex
2013-08-24 R-HSA-4411351 TCF/LEF:CTNNB1 bind the AXIN2 gene BibTex
2013-08-24 R-HSA-201717 CSNK2-mediated phosphorylation of DVL BibTex
2013-08-24 R-HSA-201669 Beta-catenin translocates to the nucleus BibTex
2013-08-24 R-HSA-201712 Beta-catenin:TCF associates with BCL9 and PYGO BibTex
2013-08-24 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta BibTex
2013-08-24 R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI BibTex
2013-08-24 R-HSA-4411367 TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene BibTex
2013-08-24 R-HSA-4411357 TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene BibTex
2013-08-24 R-HSA-4411402 Activation of NLK BibTex
2013-08-24 R-HSA-4411373 NLK translocates to nucleus BibTex
2013-08-24 R-HSA-4411383 NLK phosphorylates TCF/LEF BibTex
2013-08-17 R-XLA-4332392 translocation of Xenopus prkca to plasma membrane BibTex
2013-08-17 R-HSA-4332363 Autophosphorylation and activation of CAMK2 BibTex
2013-08-17 R-HSA-4332358 Dissociation of CaM and CAMK2 autophosphorylation BibTex
2013-08-17 R-HSA-4332359 Active calmodulin binds CAMK2 BibTex
2013-08-08 R-HSA-4332388 Activation of MAP3K7 in response to WNT