<<< Go back

Veronica Shamovsky

 ORCID
https://orcid.org/0000-0002-2187-2241
Project
Reactome
Affiliation
NYU School of Medicine, Department of Biochemistry
Authored Reactions (667)
Date Identifier Reaction Reference
2020-12-25 R-HSA-9705320 TBK1, IKBKE are autophosphorylated at Ser172 BibTex
2020-12-25 R-HSA-9705137 TBK1 or IKBKE forms homodimers BibTex
2020-12-25 R-HSA-9705323 Phosphorylation of TBK1/IKBKE BibTex
2020-12-25 R-HSA-9705145 TBK1, IKBKE form homodimers BibTex
2020-12-25 R-HSA-9709831 HSP90 binds TBK1 and IRF3 BibTex
2020-12-25 R-HSA-9709842 MAVS binds TOMM70 BibTex
2020-12-25 R-HSA-9709852 MAVS:TOMM70 recruits HSP90:TBK1:IRF3 BibTex
2020-11-09 R-HSA-9710490 The GSDME gene promoter is hypermethylated BibTex
2020-11-09 R-HSA-9710480 Decitabine triphosphate incorporates into DNA BibTex
2020-11-09 R-HSA-9710468 GSDME variant does not bind PIPs BibTex
2020-11-09 R-HSA-9693324 Disulfiram covalently modifies Cys191 in GSDMD BibTex
2020-11-09 R-HSA-9716258 Dimethyl fumarate modifies Cys191 in GSDMD BibTex
2020-11-09 R-HSA-9647643 GSDMD (1-275) binds bacterial cardiolipin BibTex
2020-11-09 R-HSA-9710354 GSDME (1-270) binds cardiolipin BibTex
2020-11-09 R-HSA-9710353 GSDMD (1-275) binds cardiolipin BibTex
2020-11-09 R-HSA-9710254 GSDME oligomerizes BibTex
2020-11-09 R-HSA-9647632 CASP3 cleaves GSDME BibTex
2020-11-09 R-HSA-9710323 TP53 or TP63 binds the GSDME gene BibTex
2020-11-09 R-HSA-9710306 GSDME expression mediated by TP53, TP63 BibTex
2020-11-09 R-HSA-9710263 GZMB cleaves GSDME BibTex
2020-11-09 R-HSA-9647660 GSDME (1-270) binds PIPs BibTex
2020-11-09 R-HSA-9686088 CASP3 cleaves GSDMD BibTex
2020-11-09 R-HSA-9647680 CASP1 cleaves GSDMD BibTex
2020-11-09 R-HSA-9710101 CASP4, CASP5 cleave GSDMD BibTex
2020-11-09 R-HSA-9710295 IRF2 or IRF1 binds the GSDMD gene promoter BibTex
2020-11-09 R-HSA-9710294 GSDMD expression mediated by IRF2, IRF1 BibTex
2020-11-09 R-HSA-9710106 ELANE cleaves GSDMD BibTex
2020-11-09 R-HSA-9647631 GSDMD (1-275) binds PIPs BibTex
2020-11-09 R-HSA-9647645 GSDMD oligomerizes into arc-, slit-shaped structures BibTex
2020-11-09 R-HSA-9647619 GSDMD forms ring?shaped oligomers BibTex
2020-08-19 R-HSA-9697750 RIPK1 is cleaved by CASP8:FLIP(L) BibTex
2020-08-19 R-HSA-9697747 Caspase-8 and FLIP(L) processing at TNFR signaling complex BibTex
2020-07-08 R-HSA-9693929 RIPK1 variant is not cleaved by CASP8 BibTex
2020-05-21 R-HSA-9688456 MLKL binds FLOT1, FLOT2 BibTex
2020-05-21 R-HSA-9686920 PELI1 ubiquitinates RIPK3 at K363 BibTex
2020-05-21 R-HSA-9687625 ATP binds MLKL BibTex
2020-05-21 R-HSA-9686922 PELI1 binds activated RIPK1:RIPK3 BibTex
2020-05-21 R-HSA-9688459 RIPK3 binds HSP90:CDC37 BibTex
2020-05-21 R-HSA-9688832 MLKL binds PDCD6IP and SDCBP BibTex
2020-05-21 R-HSA-9698844 MLKL binds HSP90:CDC37 BibTex
2020-05-21 R-HSA-9688838 RIPK3 binds STUB1 BibTex
2020-05-21 R-HSA-9688831 STUB1 ubiquitinates RIPK3 at K55, K363 BibTex
2020-05-21 R-HSA-9693978 Small molecule inhibitor binds RIPK1, RIPK3 BibTex
2020-05-21 R-HSA-9687828 O-GlcNAcylation of RIPK3 (TLR4 signaling) BibTex
2020-05-21 R-HSA-9687638 MLKL binds IP4, IP5 and IP6 BibTex
2020-05-21 R-HSA-9686930 RIPK3 is cleaved by CASP8 BibTex
2020-05-21 R-HSA-9687455 HSV1 RIR1 binds RIPK3 BibTex
2020-05-21 R-HSA-9687465 HSV1 RIR1 binds RIPK1 BibTex
2020-05-21 R-HSA-9698677 HCMV UL36 binds MLKL BibTex
2020-05-21 R-HSA-9686343 IAV NS1 binds MLKL BibTex
2020-05-21 R-HSA-9687458 HSV1 RIR1 binds CASP8 BibTex
2020-05-21 R-HSA-9686345 SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer BibTex
2020-05-21 R-HSA-9686336 SARS-CoV-1 3a oligomerizes BibTex
2020-05-21 R-HSA-9686338 SARS-CoV-1 3a binds the lysosomal membrane BibTex
2019-12-12 R-HSA-9670673 FIX is secreted BibTex
2019-12-04 R-HSA-9670014 Factor VIIIa dissociates BibTex
2019-11-19 R-HSA-9668023 TPST1,2 transfer SO4(2-) from PAPS to FVIII BibTex
2019-09-18 R-HSA-9661625 FVIII is secreted BibTex
2019-09-09 R-HSA-9668253 Hyperactivation of factor X by FVIIIa:FIXa R384L BibTex
2019-09-09 R-HSA-9655046 Cleavage of FXII variant by KLKB1 BibTex
2019-09-09 R-HSA-9653249 Cleavage of factor XII variant by activated thrombin BibTex
2019-09-09 R-HSA-9650447 SERPING1 variant is not secreted BibTex
2019-09-09 R-HSA-9651467 SERPING1 variant does not bind kallikrein BibTex
2019-09-09 R-HSA-9651456 SERPING1 variant does not bind factor XIIa BibTex
2019-09-09 R-HSA-9673231 GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) BibTex
2019-09-09 R-HSA-9673223 FIX(29-461) variant is not activated (factor XIa catalyst) BibTex
2019-09-09 R-HSA-9670874 FIXa variant:FVIIIa does not convert FX to the active FXa BibTex
2019-09-09 R-HSA-9670888 F9 variant is not secreted BibTex
2019-09-09 R-HSA-9668365 FVIIIa variant:FIXa does not convert FX to the active FXa BibTex
2019-09-09 R-HSA-9661980 F8 variant is not secreted BibTex
2019-09-09 R-HSA-9665809 F8 variant does not bind von Willebrand factor BibTex
2019-09-09 R-HSA-9670189 F8 variant does not bind the cell membrane BibTex
2019-09-09 R-HSA-9666383 F8 variant is not cleaved by thrombin BibTex
2019-09-09 R-HSA-9668148 F8 variant is not sulfonated at Y1699 BibTex
2019-09-09 R-HSA-9670054 Defects in F8 A2 domain accelerate dissociation of the A2 domain BibTex
2019-09-09 R-HSA-9670049 Defects in F8 A1 domain accelerate dissociation of the A2 domain BibTex
2019-06-21 R-HSA-9650473 SERPING1 is secreted BibTex
2019-05-17 R-HSA-9645428 ALPK1 binds ADP-heptose BibTex
2019-05-17 R-HSA-9645524 ALPK1:ADP-heptose binds TIFA BibTex
2019-05-17 R-HSA-9645535 ALPK1 phosphorylates TIFA BibTex
2019-05-17 R-HSA-9645481 TIFA oligomerization BibTex
2019-05-17 R-HSA-9645520 ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 BibTex
2019-05-17 R-HSA-9645501 TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex BibTex
2019-05-17 R-HSA-9645414 Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer BibTex
2019-05-17 R-HSA-9645394 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation BibTex
2019-05-17 R-HSA-9645406 ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) BibTex
2019-05-17 R-HSA-9645442 Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex BibTex
2019-02-20 R-HSA-9657836 NR1H2,3 binds the ANGPTL3 gene BibTex
2019-02-20 R-HSA-9657775 Expression of ANGPTL3 regulated by NR1H2 or NR1H3 BibTex
2019-02-20 R-HSA-9657767 Expression of APOD regulated by NR1H2 or NR1H3 BibTex
2019-02-20 R-HSA-9657791 miR-144 binds to the 3'UTR of the ABCA1 mRNA BibTex
2019-02-20 R-HSA-9657786 NR1H2,3 binds the APOD gene BibTex
2018-11-30 R-HSA-9630921 NFKBIA variant binds NFkB complex BibTex
2018-11-30 R-HSA-9630923 NFkB inhibitor binds NFkB complex BibTex
2018-11-02 R-MMU-6804642 Uaca binds apoptosome BibTex
2018-10-30 R-HSA-9626817 PKC phosphorylates NCF1 BibTex
2018-10-30 R-HSA-9626848 S100A8:S100A9:AA:Ca(2+) binds NOX2 complex BibTex
2018-10-30 R-HSA-9626816 PIN1 binds p-S345-NCF1 BibTex
2018-10-30 R-HSA-9626880 MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 BibTex
2018-10-30 R-HSA-9626832 MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 BibTex
2018-10-23 R-HSA-6803998 Nitrite ion and HNO2 form a conjugated acid-base pair BibTex
2018-10-23 R-HSA-6803999 HNO2 produces N2O3 BibTex
2018-10-23 R-HSA-8942075 Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate BibTex
2018-10-23 R-HSA-6803988 N2O3 enters bacteria BibTex
2018-10-23 R-HSA-6803978 S-nitrosylation of cysteine residues in proteins by N2O3 BibTex
2018-10-23 R-HSA-8942052 Superoxide and nitric oxide react to peroxynitrite in the phagosome BibTex
2018-10-23 R-HSA-6804035 N2O3 diffuses to phagosome BibTex
2018-10-23 R-HSA-6788999 HV1-mediated H+ transfer BibTex
2018-10-23 R-HSA-6789114 Hydroxyl radical reacts with the base and sugar moiety of DNA BibTex
2018-10-23 R-HSA-8948180 Peroxynitrite oxidizes Cys residues BibTex
2018-10-23 R-HSA-6789042 Hydroxyl-initiated lipid peroxidation BibTex
2018-10-23 R-HSA-9626753 H2O2 oxidizes Cys residues to form Cys-sulfenic acid BibTex
2018-10-23 R-HSA-6789109 Superoxide anion reacts with Fe-S cluster BibTex
2018-10-23 R-HSA-6789077 Hydrogen peroxide enters the bacterium BibTex
2018-10-23 R-HSA-6789160 Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ BibTex
2018-10-23 R-HSA-6788975 Superoxide anion dismutates to H2O2 BibTex
2018-10-23 R-HSA-6803989 Nitric oxide and O2 react to NO2 BibTex
2018-10-23 R-HSA-6804006 NO and NO2 react to N2O3 BibTex
2018-10-23 R-HSA-6789208 HOCl-induced glycosaminoglycan fragmentation BibTex
2018-10-23 R-HSA-9625548 Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride BibTex
2018-10-23 R-HSA-9625540 Cys-sulfenyl chloride is converted to Cys-sulfenic acid BibTex
2018-10-23 R-HSA-8941411 OSCN- reacts with Cys residues BibTex
2018-10-23 R-HSA-9625913 Hypochlorous acid (HOCL) reacts with Lys-monochloramine BibTex
2018-10-23 R-HSA-6788974 Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) BibTex
2018-10-23 R-HSA-6789185 Chloride ion and N-acyl group react to chloramide BibTex
2018-10-23 R-HSA-6789218 Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins BibTex
2018-10-23 R-HSA-6789092 NOX2 generates superoxide anion from oxygen BibTex
2018-10-23 R-HSA-6789126 Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) BibTex
2018-10-23 R-HSA-8855490 Lactoperoxidase (LPO) produces OSCN- BibTex
2018-10-23 R-HSA-6789136 Myeloperoxidase (MPO) binds to the bacterial cell surface BibTex
2018-10-23 R-HSA-6789031 Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) BibTex
2018-10-23 R-HSA-8933635 Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide BibTex
2018-10-23 R-HSA-9625904 Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine BibTex
2018-07-27 R-HSA-9615042 Viral 2',5'-PDE cleaves 2'-5' oligoadenylates BibTex
2018-01-19 R-HSA-9028526 NR1H2 or NR1H3, NRIP1 bind the SCD gene BibTex
2018-01-19 R-HSA-9605060 Expression of SCD regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9028533 NR1H2,3, NRIP1 bind the FASN gene BibTex
2018-01-19 R-HSA-9605063 Expression of FASN regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9028525 NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene BibTex
2018-01-19 R-HSA-9605056 Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9605051 Expression of PCK1 regulated by NR1H3 BibTex
2018-01-19 R-HSA-9028524 NR1H3, NRIP1 bind the PCK1 gene BibTex
2018-01-19 R-HSA-9623365 Expression of MYLIP regulated by NR1H2,3 BibTex
2018-01-19 R-HSA-9623366 NR1H2,3 binds the MYLIP gene BibTex
2018-01-19 R-HSA-9608048 Expression of PLIN1 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9608039 NR1H2,3 binds the PLIN1 gene BibTex
2018-01-19 R-HSA-9035279 Expression of APOC4 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9024334 Co-repressor complex dissociates from the transcription unit of the ABCA1 gene BibTex
2018-01-19 R-HSA-9024326 Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex BibTex
2018-01-19 R-HSA-9618394 ARL4C gene transcription regulated by NR1H2,3 BibTex
2018-01-19 R-HSA-9618407 NR1H2,3 binds the ARL4C gene BibTex
2018-01-19 R-HSA-9618392 miR-26 binds to the 3'UTR of the ARL4C mRNA BibTex
2018-01-19 R-HSA-9024386 Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene BibTex
2018-01-19 R-HSA-9035143 NR1H2,3 binds the APOC4 gene BibTex
2018-01-19 R-HSA-9624925 miR-33 binds to the 3'UTR of the ABCA1 mRNA BibTex
2018-01-19 R-HSA-9605057 ABCA1 gene transcription regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9031512 Expression of APOE regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9031522 NR1H2,3 binds the APOE gene BibTex
2018-01-19 R-HSA-9029531 Expression of ABCG5 regulated by NR1H2,3 BibTex
2018-01-19 R-HSA-9035167 NR1H2,3 binds the EEPD1 gene BibTex
2018-01-19 R-HSA-9031518 NR1H2,3 binds the APOC1 gene BibTex
2018-01-19 R-HSA-9029521 NR1H2,3 binds the ABCG5 gene BibTex
2018-01-19 R-HSA-9035281 NR1H3 gene transcription regulated by NR1H2,3 BibTex
2018-01-19 R-HSA-9038545 miR-613 binds to the 3'UTR of the NR1H3 mRNA BibTex
2018-01-19 R-HSA-9029591 Expression of ABCG8 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9031510 Expression of APOC1 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9024361 Expression of ABCG1 regulated by NR1H2,3 BibTex
2018-01-19 R-HSA-9618486 miR-26 binds to the 3'UTR of the ABCA1 mRNA BibTex
2018-01-19 R-HSA-9035180 Expression of EEPD1 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9029551 NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex BibTex
2018-01-19 R-HSA-9035169 Expression of CETP regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9035133 NR1H2,3 binds the CETP gene BibTex
2018-01-19 R-HSA-9031521 NR1H2,3 binds the APOC2 gene BibTex
2018-01-19 R-HSA-9031527 Expression of APOC2 regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9605052 NR1H3 mRNA is translated BibTex
2018-01-19 R-HSA-9029561 NCOA1 recruits EP300 to the ABCA1 promoter BibTex
2018-01-19 R-HSA-9624353 NR1H2,3 binds the PLTP gene BibTex
2018-01-19 R-HSA-9618405 ARL4C mRNA is translated BibTex
2018-01-19 R-HSA-9035185 NR1H2,3 binds the NR1H3 gene BibTex
2018-01-19 R-HSA-9029555 NR1H2,3 binds the ABCG8 gene BibTex
2018-01-19 R-HSA-9618479 ABCA1 mRNA is translated BibTex
2018-01-19 R-HSA-9619756 NR1H2 binds ABCA1 BibTex
2018-01-19 R-HSA-9624365 Expression of PLTP regulated by NR1H2 or NR1H3 BibTex
2018-01-19 R-HSA-9631296 NR1H2,3 binds the FABP6 gene BibTex
2018-01-19 R-HSA-9029517 Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex BibTex
2018-01-19 R-HSA-9029580 NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex BibTex
2018-01-19 R-HSA-9029566 Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene BibTex
2018-01-19 R-HSA-9029536 Expression of UGT1A3 BibTex
2018-01-19 R-HSA-9607342 Expression of FABP6 regulated by NR1H2,3 BibTex
2017-07-26 R-HSA-9627056 Procaspase 9 forms dimer BibTex
2017-07-26 R-HSA-9627106 SMAC (DIABLO) forms dimer BibTex
2017-07-26 R-HSA-6805811 Release of SEPT4 from mitochondria BibTex
2017-07-26 R-HSA-6805507 APAF1 binds AVEN BibTex
2017-07-26 R-HSA-9627078 XIAP binds CASP9 BibTex
2017-07-26 R-HSA-6804596 APAF1:CYCS binds APIP BibTex
2017-07-26 R-HSA-9627089 CASP9 is phosphorylated at T125 BibTex
2017-07-26 R-HSA-6805426 CARD8 binds CASP9(1-416) BibTex
2017-07-26 R-HSA-6804652 UACA binds apoptosome BibTex
2017-07-26 R-HSA-9627107 XIAP binds CASP7 BibTex
2017-07-26 R-HSA-9627104 XIAP binds CASP3 BibTex
2017-07-26 R-HSA-9627350 SMAC (DIABLO) binds XIAP BibTex
2017-07-26 R-HSA-9627369 SEPT4 binds XIAP BibTex
2017-06-20 R-HSA-9009526 CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene BibTex
2017-06-20 R-HSA-9009533 TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter BibTex
2017-06-20 R-HSA-9008315 TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen BibTex
2017-06-20 R-HSA-9008285 NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 BibTex
2017-06-20 R-HSA-9009541 ESR1 binds to TFF1 gene promoter BibTex
2017-06-20 R-HSA-9009536 DDX5 binds ESR1:estrogen:TFF1 gene promoter BibTex
2017-06-20 R-HSA-9008271 CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter BibTex
2017-06-20 R-HSA-9008267 ESR1 binds to TGFA gene promoter BibTex
2017-06-08 R-HSA-9008258 NCOA3 binds ESR1:estrogen:TFGA gene BibTex
2017-06-08 R-HSA-9008270 NCOA1 binds ESR1:estrogen:TGFA gene BibTex
2017-03-27 R-HSA-9009941 RNASEL cleaves viral ssRNA BibTex
2017-03-27 R-HSA-9009936 RNASEL cleaves cellular ssRNA BibTex
2017-03-27 R-HSA-8985201 ABCE1 binds RNASEL BibTex
2017-03-27 R-HSA-9009950 PDE12 cleaves 2'-5' oligoadenylates BibTex
2017-03-27 R-HSA-8985104 OAS2 produces oligoadenylates BibTex
2017-03-27 R-HSA-8985123 RNASEL binds 2'-5' oligoadenylate BibTex
2017-03-27 R-HSA-8985157 OAS3 binds viral dsRNA BibTex
2017-03-27 R-HSA-8985091 OAS3 produces oligoadenylates BibTex
2017-03-27 R-HSA-8983680 OAS1 produces oligoadenylates BibTex
2017-03-27 R-HSA-8985153 OASL binds DDX58 BibTex
2017-03-27 R-HSA-8983688 OAS1 oligomerizes BibTex
2017-03-27 R-HSA-8985138 OAS2 binds viral dsRNA BibTex
2017-03-27 R-HSA-8985097 OAS2 dimerizes BibTex
2017-03-27 R-HSA-8983671 OAS1 binds viral dsRNA BibTex
2016-11-19 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-11-19 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-11-19 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-11-19 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-11-19 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-11-19 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-11-19 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
2016-11-19 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-11-19 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-11-19 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-11-19 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-11-19 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-11-19 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-11-19 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-05-10 R-HSA-8870678 Cleaved fibrinogen products bind TLR4:LY96 BibTex
2016-05-06 R-HSA-8869694 oxPL binds CD14 BibTex
2016-05-06 R-HSA-8869683 oxPL binds LBP BibTex
2016-05-06 R-HSA-8869667 oxLDL:CD36 binds TLR4:TLR6 BibTex
2015-12-19 R-HSA-8850356 TCR binds microbial lipid-based antigen via CD1 BibTex
2015-12-19 R-HSA-8850326 TCR binds self-lipid-based antigen via CD1 BibTex
2015-10-05 R-HSA-6807581 HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 BibTex
2015-10-05 R-HSA-6810643 EPPIN protein complex binds bacteria BibTex
2015-10-05 R-HSA-6809521 BPIF binds bacteria BibTex
2015-10-05 R-HSA-6807144 HTN1,HTN3 or HTN5 binds the bacterial anionic surface BibTex
2015-10-05 R-HSA-6801687 PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) BibTex
2015-10-05 R-HSA-6803104 DCD forms oligomeric complex BibTex
2015-10-05 R-HSA-6803060 DCD(63-110) is processed to DCD(63-109) BibTex
2015-10-05 R-HSA-6802999 DCD is processed into DCD(63-110) BibTex
2015-10-05 R-HSA-6803047 DCD peptide binds bacterial membrane phospholipids BibTex
2015-10-05 R-HSA-6801808 REG3A,REG3G binds bacterial peptidoglycan BibTex
2015-10-05 R-HSA-6798528 S100A8:S100A9 binds Mn2+ BibTex
2015-10-05 R-HSA-6798474 S100A8:S100A9 binds Zn2+ BibTex
2015-10-05 R-HSA-6798489 S100A7 or S100A7A binds Zn2+ BibTex
2015-10-05 R-HSA-8948027 RNASEs bind bacterial phospholipids BibTex
2015-10-05 R-HSA-6803545 ATP7A transports cytosolic Cu2+ to phagosomal lumen BibTex
2015-10-05 R-HSA-6799977 PGLYRP2 hydrolyzes bacterial peptidoglycan BibTex
2015-10-05 R-HSA-6789072 PGLYRP1 binds bacterial peptidoglycan BibTex
2015-10-05 R-HSA-6803063 RNASEs bind bacterial LPS, PGN BibTex
2015-10-05 R-HSA-6806732 GNLY binds the bacterial cell surface BibTex
2015-10-05 R-HSA-8862300 LYZ binds bacterial peptidoglycan BibTex
2015-10-05 R-HSA-8862320 LYZ hydrolyzes peptidoglycans in the bacterial cell wall BibTex
2015-10-05 R-HSA-6799981 PGLYRP2 binds bacterial peptidoglycan BibTex
2015-10-05 R-HSA-6810724 PI3 binds the bacterial surface BibTex
2015-10-05 R-HSA-6813626 LEAP2 binds bacteria BibTex
2015-10-05 R-HSA-6808566 CHGA-derived peptide binds the bacterial cell surface BibTex
2015-10-05 R-HSA-6801762 REG3A oligomerize to form a pore complex BibTex
2015-10-05 R-HSA-6804527 INTL1 binds bacterial glycans BibTex
2015-10-05 R-HSA-6807565 GNLY is transferred to the phagosome BibTex
2015-10-05 R-HSA-6807578 GNLY binds the bacterial cell surface in the phagosome BibTex
2015-10-05 R-HSA-6807585 BPI binds LPS on the bacterial surface BibTex
2015-10-05 R-HSA-6801776 REG3A binds bacterial phospholipids BibTex
2015-10-05 R-HSA-6799959 PGLYRP3,4 binds bacterial peptidoglycan BibTex
2015-10-05 R-HSA-8862771 PLA2G2A binds bacterial phospholipids BibTex
2015-10-05 R-HSA-6813659 ELANE, CTSG or PRTN3 binds bacteria BibTex
2015-10-05 R-HSA-6801766 Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) BibTex
2015-09-12 R-HSA-5432852 SFTPA/SFTPD binds TLR4:LY96 BibTex
2015-09-12 R-HSA-6804100 HMGB1 binds LPS BibTex
2015-09-12 R-HSA-5432814 SFTPA/SFTPD binds TLR2:TLR1 BibTex
2015-09-12 R-HSA-6804099 HMGB1 binds LTP BibTex
2015-09-12 R-HSA-6805981 HMGB1 release from cells BibTex
2015-09-12 R-HSA-5432825 HMGB1 binds TLR4:LY96 BibTex
2015-09-12 R-HSA-5432849 S100A8:S100A9 binds TLR4:LY96 BibTex
2015-09-12 R-HSA-6805943 S100A1 binds TLR4:LY96 BibTex
2015-05-18 R-HSA-5693055 TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes BibTex
2015-05-13 R-HSA-5693108 TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains BibTex
2015-05-13 R-HSA-5684275 IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 BibTex
2015-05-13 R-HSA-5684261 MAP3K8 is phosphorylated BibTex
2015-05-13 R-HSA-5684267 IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex BibTex
2015-05-13 R-HSA-5684248 SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 BibTex
2015-05-13 R-HSA-5684250 SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 BibTex
2015-05-13 R-HSA-5684273 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 BibTex
2015-05-12 R-HSA-5692550 Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 BibTex
2015-05-12 R-HSA-5661517 LUBAC comlex binds OTULIN BibTex
2015-05-12 R-HSA-5626962 GNB2L1 binds IKKA:IKKB:NEMO BibTex
2015-05-12 R-HSA-5357928 CLIP3 and CYLD bind TNF signaling complex BibTex
2015-05-12 R-HSA-5634228 TRAF1 is cleaved by caspases BibTex
2015-05-12 R-HSA-5626953 TNF-alpha:TNFR1 binds DENN/MADD BibTex
2015-05-12 R-HSA-5634221 TRAF1 binds TRAF2 within TNFR1 signaling complex BibTex
2015-05-12 R-HSA-5357845 RIPK1 is deubiquitinated BibTex
2015-05-12 R-HSA-5357831 CYLD is phosphorylated by IKK BibTex
2015-05-12 R-HSA-5357776 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG BibTex
2015-05-12 R-HSA-5357757 BIRC(cIAP1/2) ubiquitinates RIPK1 BibTex
2015-05-12 R-HSA-5357860 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex BibTex
2015-05-12 R-HSA-5357780 TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) BibTex
2015-05-12 R-HSA-5357904 TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC BibTex
2015-05-12 R-HSA-5626988 TNF-alpha:TNFR1 binds NSMAF BibTex
2015-05-12 R-HSA-5626982 TNF-alpha:TNFR1:NSMAF binds GNB2L1 BibTex
2015-05-12 R-HSA-5626981 TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 BibTex
2015-05-12 R-HSA-5357828 RIPK1 is cleaved by CASP8 BibTex
2015-02-15 R-HSA-5609665 IKBKA, IKBKB and IKBKG form IKK complex BibTex
2015-02-10 R-HSA-5675470 BIRC2/3 (cIAP1/2) is autoubiquitinated BibTex
2014-05-21 R-HSA-5602549 Defective TLR3 does not bind viral dsRNA BibTex
2014-05-21 R-HSA-5602624 Defective TRAF3 does not transmit the signal BibTex
2014-05-21 R-HSA-5602316 Defective MyD88 does not oligomerize within the complex of activated TLR5 BibTex
2014-05-21 R-HSA-5607838 Defective UNC93B1 does not bind TLR3 BibTex
2014-05-21 R-HSA-5228840 Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG BibTex
2014-05-21 R-HSA-5602603 IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway BibTex
2014-05-21 R-HSA-5602472 Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex BibTex
2014-05-21 R-HSA-5602606 Defective MyD88 does not bind MAL(TIRAP):TLR2/4 BibTex
2014-05-21 R-HSA-5602383 Defective MyD88 does not oligomerize within the activated TLR2/4 complex BibTex
2014-05-21 R-HSA-5262921 Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) BibTex
2014-05-21 R-HSA-5602672 Defective IRAK4 does not bind MyD88 within the TLR2/4 complex BibTex
2014-05-21 R-HSA-5602353 Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 BibTex
2014-05-21 R-HSA-5602712 TICAM1 deficiency blocks TLR3 pathway BibTex
2014-05-21 R-HSA-5228811 NFKBIA variant is not phosphorylated within IkBA:NF-kappaB BibTex
2014-05-16 R-HSA-9013985 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 BibTex
2014-05-16 R-HSA-9013990 TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA BibTex
2014-05-16 R-HSA-5362486 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 BibTex
2014-05-16 R-HSA-5362500 TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 BibTex
2014-02-18 R-HSA-5333051 RPA1 binds HSF1 BibTex
2013-12-20 R-HSA-5620975 MLKL binds PIPs BibTex
2013-12-20 R-HSA-5357927 MLKL oligomerizes BibTex
2013-12-20 R-HSA-5218906 RIPK3 phosphorylates MLKL BibTex
2013-12-20 R-HSA-5213464 RIPK1 is phosphorylated BibTex
2013-12-20 R-HSA-5213462 RIPK3 binds RIPK1 BibTex
2013-12-20 R-HSA-5213466 RIPK3 is phosphorylated BibTex
2013-12-20 R-HSA-5218905 RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils BibTex
2013-12-20 R-HSA-5218891 RIPK1:RIPK3 oligomer binds MLKL BibTex
2013-11-19 R-HSA-5324617 HSP90:FKBP4:PTGES3 binds HSF1 trimer BibTex
2013-10-29 R-HSA-4793911 MAPKAPK2 phosphorylates HSF1 BibTex
2013-10-29 R-HSA-3371467 SIRT1 deacetylates HSF1 BibTex
2013-10-29 R-HSA-3371518 SIRT1 binds to HSF1 BibTex
2013-10-29 R-HSA-3371435 Constitutive phosphorylation by GSK3 BibTex
2013-10-29 R-HSA-3371531 Constitutive phosphorylation by pERK1/2 BibTex
2013-10-29 R-HSA-4793925 p-S303,307-HSF1 binds YWHAE (14-3-3) BibTex
2013-10-29 R-HSA-3371567 DBC1 is phosphorylated by ATM/ART BibTex
2013-10-29 R-HSA-3371537 DBC1 binds SIRT1 BibTex
2013-10-29 R-HSA-5082387 Phosphorylation of HSF1 at Ser230 induces transactivation BibTex
2013-10-29 R-HSA-5082409 Dissociation of HSF1:HSP90 complex in the nucleus BibTex
2013-10-29 R-HSA-5082391 Trimerization of HSF1 in the nucleus BibTex
2013-10-29 R-HSA-3371586 Dissociation of cytosolic HSF1:HSP90 complex BibTex
2013-10-29 R-HSA-5324632 Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates BibTex
2013-10-29 R-HSA-3371591 Trimerization of cytosolic HSF1 BibTex
2013-10-29 R-HSA-3371527 HSF1 trimer translocates to the nucleus BibTex
2013-10-29 R-HSA-4793819 HSF1 trimer binds HSE on the target gene BibTex
2013-10-29 R-HSA-5082356 HSF1-mediated gene expression BibTex
2013-10-29 R-HSA-5082405 Phosphorylation of HSF1 at Ser326 induces transactivation BibTex
2013-10-29 R-HSA-3371582 HSBP1 binds HSF1 trimer BibTex
2013-10-29 R-HSA-5082384 HSP70:DNAJB1 binds HSF1 BibTex
2013-10-29 R-HSA-5082369 Acetylated HSF1 dissociates from DNA BibTex
2013-10-29 R-HSA-3371554 HSF1 acetylation at Lys80 BibTex
2013-05-13 R-HSA-5675456 FLIP(L) and procaspase-8 form heterodimer BibTex
2013-05-13 R-HSA-3465429 FLIP(S) and procaspase-8 form heterodimer BibTex
2013-05-13 R-HSA-2672196 Viral serpin blocks caspase-8 activity BibTex
2013-05-13 R-HSA-3371359 FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling BibTex
2013-05-13 R-HSA-3465448 Caspase-8 and FLIP(L) processing at DISC BibTex
2013-05-13 R-HSA-3465459 FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling BibTex
2013-05-13 R-HSA-3371360 FLIP(L) and procaspase-8 form heterodimer in TNF signaling BibTex
2013-05-13 R-HSA-3371385 TNF-alpha is cleaved by ADAM17 (TACE) BibTex
2013-05-13 R-HSA-3371353 Soluble TNF-alpha binds TNFR1 BibTex
2013-03-28 R-HSA-8948703 NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 BibTex
2013-03-28 R-HSA-3249392 NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 BibTex
2013-02-06 R-HSA-3134821 DNA-PK binds microbial dsDNA BibTex
2013-02-06 R-HSA-3204303 MRE11 binds cytosolic DNA BibTex
2013-02-06 R-HSA-3134953 DHX36 or DHX9 binds MyD88 BibTex
2013-02-06 R-HSA-3134962 DHX36 binds DNA BibTex
2013-02-06 R-HSA-3134954 DHX9 binds DNA BibTex
2013-02-06 R-HSA-3134883 Beta-catenin enhances association of IRF3 with CBP/p300 BibTex
2013-02-06 R-HSA-3134896 LRR FLII-interacting protein 1 binds dsDNA BibTex
2013-02-06 R-HSA-3134901 LRR FLII-interacting protein 1 associates with beta-catenin BibTex
2013-02-06 R-HSA-3134904 Phosphorylation of beta-catenin at Ser552 BibTex
2013-02-06 R-HSA-3134914 Beta-catenin migrates to the nucleus BibTex
2013-02-06 R-HSA-9013869 DDX41 binds bacterial c-di-AMP, c-di-GMP BibTex
2013-02-06 R-HSA-3134822 DDX41 binds viral dsDNA BibTex
2013-02-06 R-HSA-3244647 cGAS binds cytosolic DNA BibTex
2013-02-06 R-HSA-3244614 cGAS produces cyclic GMP-AMP BibTex
2013-02-06 R-HSA-3134800 STING dimerization BibTex
2013-02-06 R-HSA-3134946 DDX41 ubiquitination by TRIM21 BibTex
2013-02-06 R-HSA-3249386 DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 BibTex
2013-02-06 R-HSA-3244605 TREX1 binds retroviral-derived DNA BibTex
2013-02-06 R-HSA-3245943 Viral DNA cleavage by TREX1 BibTex
2013-02-06 R-HSA-8948709 DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 BibTex
2013-02-06 R-HSA-3134804 STING ubiquitination by TRIM32 or TRIM56 BibTex
2013-02-06 R-HSA-1964496 STING binds TRIM32 or TRIM56 BibTex
2012-12-20 R-HSA-2870221 E-selectin binds E-selectin ligand BibTex
2012-12-20 R-GGA-2173317 C3a anaphylatoxin binds C3a receptor BibTex
2012-12-20 R-GGA-2132085 Cleavage of C3 by surface-bound C3 convertases BibTex
2012-12-20 R-GGA-2132100 Fluid-phase proteolytic cleavage of factor B BibTex
2012-12-20 R-GGA-2132104 Complement factor B binds to the hydrolyzed form of C3 BibTex
2012-12-20 R-GGA-2132047 Spontaneous hydrolysis of an internal thioester bond in complement factor C3 BibTex
2012-12-20 R-GGA-2132074 Cleavage of surface-bound factor B BibTex
2012-12-20 R-GGA-2132061 Complement factor B binds to surface-bound C3b fragment BibTex
2012-12-20 R-GGA-2132210 C3b fragment binds to the target cell surface BibTex
2012-12-20 R-GGA-2173323 Cleavage of C3 by fluid-phase C3i:factor B BibTex
2012-12-20 R-GGA-2132222 Cleavage of factor B to form classical C3 convertase BibTex
2012-12-20 R-GGA-2132096 Formation of C4b:factor B complex BibTex
2012-12-20 R-GGA-2132248 C4b binds to target cell surface BibTex
2012-12-20 R-GGA-2132233 Proteolytic cleavage of complement factor C4 BibTex
2012-12-20 R-GGA-2132065 C1r activates C1s component within C1 complement complex BibTex
2012-12-20 R-GGA-2132122 Activation of C1r within the C1complement complex BibTex
2012-12-20 R-GGA-2132064 Antigen bound antibody interacts with C1complement complex BibTex
2012-12-20 R-GGA-2132206 MASPs activation BibTex
2012-12-20 R-GGA-2132187 MBL or ficolin binds an oligosaccharide pattern on the target cell surface BibTex
2012-12-20 R-GGA-2173318 C5a anaphylatoxin binds C5a receptor BibTex
2012-12-20 R-GGA-2132278 Cleavage of C5 by C5 convertases BibTex
2012-12-20 R-GGA-2132264 Formation of alternate C5 convertase BibTex
2012-12-20 R-GGA-2132269 Formation of classical C5 convertase BibTex
2012-12-20 R-GGA-2132201 Opsonization with C3b or C4b BibTex
2012-12-20 R-GGA-2859050 Hydrolysis of C4b BibTex
2012-12-20 R-GGA-2530565 iC3b proteolysis BibTex
2012-12-20 R-GGA-2132276 Complement factor I inactivates C3b BibTex
2012-12-20 R-GGA-2132261 Complement factor H binds to C3b BibTex
2012-12-20 R-GGA-2132260 Complement factor I inactivates surface-bound C3b BibTex
2012-12-20 R-GGA-2132277 Complement factor H binds to surface-bound C3b BibTex
2012-12-20 R-GGA-2132271 Factor H displaces Bb in Cb:Bb complex BibTex
2012-12-20 R-GGA-2132136 Vitronectin binds to C5b-C7 complex BibTex
2012-12-20 R-GGA-2132060 Formation of C5b:C6:C7 BibTex
2012-12-20 R-GGA-2132284 Formation of C5b:C6 BibTex
2012-12-20 R-GGA-2530573 CREG(CR1L) binds to surface-bound C3 convertases BibTex
2012-12-20 R-GGA-2132247 CD59 binds C5b:C6:C7:C8 BibTex
2012-12-20 R-GGA-2132094 C8 binds to C5b:C6:C7 complement complex BibTex
2012-12-20 R-GGA-2132133 C5b:C6:C7 inserts into the target cell membrane BibTex
2012-12-20 R-GGA-2132088 Vitronectin prevents C9 polymerization BibTex
2012-12-20 R-GGA-2530591 CREG (CR1L) causes dissociation of C3 convertases BibTex
2012-12-20 R-GGA-2132283 Factor H binds to host cell surface BibTex
2012-12-20 R-GGA-2530584 CREM (CREMP) binds to surface-bound C3b or C4b BibTex
2012-12-20 R-GGA-2132221 C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) BibTex
2012-10-17 R-HSA-2855125 Ficolin-1 binds to molecular patterns on the target cell surface BibTex
2012-10-17 R-HSA-2855054 Ficolin-2 binds to molecular patterns on the target cell surface BibTex
2012-10-17 R-HSA-2855077 Ficolin-3 binds to molecular patterns on the target cell surface BibTex
2012-10-17 R-HSA-3266557 Factor I cleaves iC3b BibTex
2012-10-17 R-HSA-2855047 Hydrolysis of internal thioester in C4b BibTex
2012-10-17 R-HSA-2530453 Vitronectin (VTN) binds to C5b:C6:C7 BibTex
2012-10-17 R-HSA-2530445 CD59 inhibits MAC formation BibTex
2012-10-17 R-HSA-2530429 Formation of soluble VTN:C5b-C9 BibTex
2012-07-09 R-HSA-3249370 p-S407,Y641-STAT6 dimer migrates to the nucleus BibTex
2012-07-09 R-HSA-3249372 p-S407,Y641-STAT6 is dimerized BibTex
2012-07-09 R-HSA-3249379 p-S407-STAT6 is phosphorylated at Tyr641 BibTex
2012-07-09 R-HSA-3249378 STING recruits TBK1 and STAT6 BibTex
2012-07-09 R-HSA-3249390 TBK1 is phosphorylated within STING:TBK1:STAT6 complex BibTex
2012-07-09 R-HSA-3249371 TBK1 phosphorylates STAT6 at Ser407 BibTex
2012-07-09 R-HSA-1834951 IFI16 binds cytosolic dsDNA BibTex
2012-07-09 R-HSA-1834939 STING recruits TBK1 and IRF3 BibTex
2012-07-09 R-HSA-2396002 TBK1 is phosphorylated within STING:TBK1:IRF3 complex BibTex
2012-07-09 R-HSA-2396007 IRF3 is phosphorylated by TBK1 BibTex
2012-07-09 R-HSA-3244643 STING binds cyclic GMP-AMP BibTex
2012-07-09 R-HSA-2396009 STING binds c-di-GMP BibTex
2012-07-09 R-HSA-2395992 p-T,4S-IRF3 is dimerized BibTex
2012-07-09 R-HSA-1964482 RNA polymerase III transcribes microbial dsDNA to dsRNA BibTex
2012-05-15 R-HSA-9013895 Caspase-8 processing within TLR3 complex BibTex
2012-05-15 R-HSA-9013889 TLR3-induced ripoptosome assembly BibTex
2012-05-15 R-HSA-9013963 RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis BibTex
2012-05-15 R-HSA-9014320 SARM binds viral dsRNA:TLR3:TICAM1 BibTex
2012-05-15 R-HSA-2559439 CD14:LPS binds CR3 BibTex
2012-05-15 R-HSA-2559568 SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 BibTex
2012-05-15 R-HSA-2559456 TIRAP binds PIP2-rich regions in the plasma membrane BibTex
2012-05-15 R-HSA-2569057 RIP3 binds TRIF to mediate necroptosis BibTex
2012-05-15 R-HSA-2562541 TLR4-induced ripoptosome assembly BibTex
2012-05-15 R-HSA-2562564 Caspase-8 processing within TLR4 complex BibTex
2012-05-15 R-HSA-2559468 TLR1/2 ligand binds to CD14 BibTex
2012-05-15 R-HSA-2559464 TLR6/2 ligand associates with CD14 and CD36 within lipid rafts BibTex
2012-04-26 R-HSA-9013974 Auto-ubiquitination of TRAF3 within activated TLR3 complex BibTex
2012-04-26 R-HSA-9013992 TRAF3 binds to TRIF:activated TLR3 complex BibTex
2012-04-26 R-HSA-2201338 TRAF3 binds TICAM1:activated TLR4 complex BibTex
2012-04-26 R-HSA-2213017 Auto-ubiquitination of TRAF3 BibTex
2012-04-20 R-HSA-2262777 TRAF6 binds to p-IRAK2 BibTex
2012-04-20 R-HSA-2201341 Endocytosis of TRAM (TICAM2) BibTex
2012-04-20 R-HSA-2201293 Endocytosis of TLR4:LY96:LPS:CD14 BibTex
2012-04-20 R-HSA-2201316 Activated TLR2/4 interacts with MAL (TIRAP) BibTex
2012-04-20 R-HSA-2559414 Activated TLR2/4:TIRAP interacts with BTK BibTex
2012-04-20 R-HSA-2201322 TIRAP is phosphorylated by BTK BibTex
2011-10-19 R-HSA-1678981 TLR9 processing at neutral pH BibTex
2011-10-19 R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 BibTex
2011-10-19 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex BibTex
2011-10-19 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 BibTex
2011-10-19 R-HSA-1678998 Endosomal TLRs pass through the Golgi BibTex
2011-10-19 R-HSA-1678927 UNC93B1 delivers endosomal full-length TLRs to endolysosome BibTex
2011-10-19 R-HSA-1678920 TLR processing at low pH BibTex
2011-09-21 R-HSA-1679589 Engulfed CpG DNA binds to endosomal full-length TLR9 BibTex
2011-09-21 R-HSA-1679098 Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer BibTex
2011-09-21 R-HSA-2032396 Dimerized phospho-IRF3 migrates to the nucleus BibTex
2011-09-21 R-HSA-1606324 Recruitment TBK1 to dsDNA:ZBP1 followed by its activation BibTex
2011-09-21 R-MMU-1810473 Recruitment Tbk1 to dsDNA:Dai followed by its activation BibTex
2011-09-21 R-MMU-1810458 Recruitment of Irf3 to activated Dai:Tbk1 BibTex
2011-09-21 R-HSA-1606345 Recruitment of IRF3 to activated ZBP1:TBK1 BibTex
2011-09-21 R-HSA-1606327 Phosphorylation and release of IRF3 BibTex
2011-09-21 R-HSA-1591234 ZBP1 binds cytosolic DNA BibTex
2011-09-21 R-HSA-1810457 ZBP1(DAI) recruits RIP1 and RIP3 BibTex
2011-01-05 R-GGA-1227753 Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization BibTex
2011-01-05 R-GGA-1227755 Recruitment of IKK complex BibTex
2011-01-05 R-GGA-1227732 IPS1 interacts with TRADD, RIP1 and FADD BibTex
2011-01-05 R-GGA-1227804 Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate BibTex
2011-01-05 R-GGA-1227695 NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. BibTex
2011-01-05 R-GGA-1227860 ITCH homolog downregulates MDA5/IPS1 signaling BibTex
2011-01-05 R-GGA-1227698 NLRX1 inhibits IPS1 signaling BibTex
2011-01-05 R-GGA-1227891 TRAF3/or TRAF6 interacts with IPS-1 BibTex
2011-01-05 R-GGA-1227893 TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex BibTex
2011-01-05 R-GGA-1227867 TANK binds polyubiquitinated TRAF3/6 BibTex
2011-01-05 R-GGA-1227885 TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation BibTex
2011-01-05 R-GGA-1227863 Recruitment of IRF to activated TBK1/IKK epsilon BibTex
2011-01-05 R-GGA-1227881 Phosphorylation and release of IRF3 BibTex
2011-01-05 R-GGA-1227694 dsRNA binds to MDA5 BibTex
2011-01-05 R-GGA-1227709 Activated MDA5 binds IPS-1 BibTex
2011-01-05 R-GGA-1227775 TRAF6/or TRAF2 interacts with IPS-1 BibTex
2011-01-05 R-GGA-1227769 TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex BibTex
2011-01-05 R-GGA-1227778 MEKK1 binds TRAF6 BibTex
2011-01-05 R-GGA-1227783 Phosphorylation of IKKs complex mediated by MEKK1 BibTex
2010-11-30 R-GGA-573297 TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation BibTex
2010-11-30 R-GGA-571318 Autoubiquitination of oligoTRAF6 bound to p-IRAK2 BibTex
2010-11-30 R-GGA-573294 Activated TRAF6 synthesizes free K63 linked pUb chains. BibTex
2010-11-30 R-GGA-573296 Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation BibTex
2010-11-30 R-GGA-571327 IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex BibTex
2010-11-30 R-GGA-571316 Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. BibTex
2010-11-30 R-GGA-451506 TLR21homodimer binds to DNA BibTex
2010-11-30 R-GGA-451439 Activated TLR7 or 21 recruits MyD88 BibTex
2010-11-30 R-GGA-451461 IRAK4 binds to the activated TLR7 or 21 BibTex
2010-11-30 R-GGA-977250 Autophosphorylation of IRAK4 bound to activated TLR5 or 15 BibTex
2010-11-30 R-GGA-977237 IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex BibTex
2010-11-30 R-GGA-977239 Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 BibTex
2010-11-30 R-GGA-532630 p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 BibTex
2010-11-30 R-GGA-451511 TLR15 binds to recognized ligand BibTex
2010-11-30 R-GGA-977238 Activated TLR5/TLR15 homodimer recruits MyD88 adaptor BibTex
2010-11-30 R-GGA-434130 IRAK4 binds to activated TLR5 or 15. BibTex
2010-10-06 R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex BibTex
2010-10-06 R-HSA-975866 MyD88 forms a complex with the activated TLR receptor BibTex
2010-10-06 R-HSA-975880 MyD88 oligomerization within the complex of activated TLR:MyD88 BibTex
2010-10-06 R-HSA-975873 IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor BibTex
2010-10-06 R-HSA-975865 IRAK4 autophosphorylation within the complex activated TLR:MyD88 BibTex
2010-10-06 R-HSA-975852 IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex BibTex
2010-10-06 R-HSA-975878 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR BibTex
2010-10-06 R-HSA-975874 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex BibTex
2010-10-06 R-HSA-975853 Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR BibTex
2010-10-06 R-HSA-975879 Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex BibTex
2010-10-02 R-GGA-1008270 Activated TAK1 leaves endosome membrane BibTex
2010-09-22 R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 BibTex
2010-08-25 R-HSA-937075 Phosphorylated TAK1 leaves activated TLR receptor complex BibTex
2010-08-25 R-HSA-975118 TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex BibTex
2010-08-25 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation BibTex
2010-08-25 R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation BibTex
2010-08-25 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 BibTex
2010-08-25 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 BibTex
2010-08-25 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 BibTex
2010-08-25 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 BibTex
2010-08-25 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex BibTex
2010-08-25 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. BibTex
2010-08-25 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 BibTex
2010-08-25 R-HSA-975857 TRAF6 binds to hp- IRAK1 or p-IRAK2 BibTex
2010-08-05 R-GGA-921145 Activated chicken TAK1 dissociates from the activated TLR3 complex BibTex
2010-06-01 R-HSA-975119 NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. BibTex
2010-06-01 R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
BibTex
2010-06-01 R-HSA-975142 Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation BibTex
2010-06-01 R-HSA-975139 IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation BibTex
2010-06-01 R-HSA-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation BibTex
2010-06-01 R-HSA-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation BibTex
2010-06-01 R-HSA-9014343 IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex BibTex
2010-06-01 R-HSA-9013986 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation BibTex
2010-06-01 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex BibTex
2010-06-01 R-HSA-937044 Pellino binds hp-IRAK1:TRAF6 BibTex
2010-06-01 R-HSA-937034 IRAK1 phosphorylates Pellino BibTex
2010-06-01 R-HSA-937050 Pellino ubiquitinates hp-IRAK1 BibTex
2010-06-01 R-HSA-937032 NEMO subunit of IKK complex binds to activated IRAK1 BibTex
2010-06-01 R-HSA-937029 IKBKG subunit of IKK complex binds polyubiquinated RIP1 BibTex
2010-06-01 R-HSA-936941 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation BibTex
2010-06-01 R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 BibTex
2010-06-01 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 BibTex
2010-06-01 R-HSA-975185 IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments BibTex
2010-06-01 R-HSA-975147 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane BibTex
2010-06-01 R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 BibTex
2010-06-01 R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP BibTex
2010-06-01 R-HSA-936963 IRAK2 induces TRAF6 oligomerization BibTex
2010-06-01 R-HSA-936942 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 BibTex
2010-06-01 R-HSA-936986 Activated TRAF6 synthesizes unanchored polyubiquitin chains BibTex
2010-06-01 R-HSA-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex BibTex
2010-06-01 R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 BibTex
2010-06-01 R-HSA-936985 Activated TLR4:TICAM1 recruits TRAF6 BibTex
2010-06-01 R-HSA-936952 Auto ubiquitination of TRAF6 bound to the activated TLR4 complex BibTex
2010-06-01 R-HSA-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex BibTex
2010-06-01 R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex BibTex
2010-05-21 R-HSA-847070 Phosphorylated TAK1 dissociates from the TLR3 receptor complex BibTex
2010-05-18 R-GGA-434058 LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 BibTex
2010-05-18 R-GGA-433940 Association of LBP with bacterial LPS BibTex
2010-04-02 R-GGA-571324 IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex BibTex
2010-03-02 R-GGA-532632 TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 BibTex
2010-02-20 R-GGA-517850 TLR2-1 : TLR1-2 heterodimer binds to its ligand BibTex
2010-02-20 R-GGA-517846 TLR2-1 :TLR1-1 binds to triacyl lipopeptide BibTex
2010-01-05 R-GGA-451470 Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 BibTex
2010-01-05 R-GGA-451463 pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex BibTex
2010-01-05 R-GGA-451466 TRAF6 binding to activated IRAK2 stimulates its oligomerization BibTex
2010-01-05 R-GGA-451450 Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 BibTex
2010-01-05 R-GGA-994000 Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation BibTex
2010-01-05 R-GGA-451447 Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 BibTex
2010-01-05 R-GGA-451481 TLR7 binds to recognized ligands BibTex
2010-01-05 R-GGA-451474 Bacterial Flagellin binds TLR5 homodimer BibTex
2009-12-16 R-HSA-9604480 NFkB complex translocates from the cytosol to the nucleus BibTex
2009-12-16 R-HSA-168166 NFkB complex is transported from cytosol to nucleus BibTex
2009-12-16 R-HSA-177694 Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 BibTex
2009-12-16 R-HSA-168933 Dimerization of phosphorylated IRF3/IRF7 BibTex
2009-12-16 R-HSA-177690 Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex BibTex
2009-12-16 R-HSA-177671 Dimerized phospho-IRF3/IRF7 is transported to the nucleus BibTex
2009-12-16 R-HSA-450358 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation BibTex
2009-12-16 R-HSA-450257 Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 BibTex
2009-12-16 R-HSA-450222 Active p38 MAPK phosphorylates MAPKAPK2 or 3 BibTex
2009-12-16 R-HSA-450325 c-FOS activation by phospho ERK1/2 BibTex
2009-12-16 R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7 BibTex
2009-12-16 R-HSA-450348 Activated human JNKs migrate to nucleoplasm BibTex
2009-12-16 R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6 BibTex
2009-12-16 R-HSA-450296 Phosphorylated MKK3/MKK6 migrates to nucleus BibTex
2009-12-16 R-HSA-450333 Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 BibTex
2009-12-16 R-HSA-177692 Activation of recruited TAK1 within the activated TLR3 complex BibTex
2009-12-16 R-HSA-9628444 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation BibTex
2009-12-16 R-HSA-450259 Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex BibTex
2009-09-22 R-GGA-442862 Nuclear export of p38 MAPK mediated by its substrate MAPKAPK2 or 3 BibTex
2009-09-22 R-GGA-442913 Active p38 MAPK phosphorylates MAPKAPK2 or 3 BibTex
2009-09-22 R-GGA-437984 Phosphorylation of MKK3/MKK6 by activated TAK1 BibTex
2009-09-22 R-GGA-442938 activated MAPK3/MAPK6 migrates to nucleus BibTex
2009-09-22 R-GGA-438019 activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 BibTex
2009-09-22 R-GGA-437995 Activated JNK migrates to the nucleoplasm BibTex
2009-09-22 R-GGA-438026 Activation and dimerization of c-JUN in the nucleus BibTex
2009-09-22 R-GGA-437999 Phosphorylation of MKK4 by activated TAK1 BibTex
2009-09-22 R-GGA-438005 MKK4 phosphorylates JNK BibTex
2009-09-22 R-GGA-451482 activated MEK2 binds ERK2 BibTex
2009-09-22 R-GGA-451516 activated MEK2 phosphorylates ERK2 BibTex
2009-09-22 R-GGA-451505 Dissociation of phospho ERK2 :phospho MEK2 complex BibTex
2009-09-22 R-GGA-451535 Dimerization of activated ERK2 BibTex
2009-09-22 R-GGA-451508 Nuclear translocation of phospho ERK2 dimer BibTex
2009-09-01 R-GGA-434097 viral dsRNA:TRL3:TICAM1 activates RIP1 BibTex
2009-08-27 R-GGA-433786 Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 BibTex
2009-08-27 R-GGA-434027 Dimerization of Phospho-IRF3 BibTex
2009-08-27 R-GGA-433967 Dimerized Phospho-IRF3 is Transported To The Nucleus BibTex
2009-08-27 R-GGA-433804 IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex BibTex
2009-08-27 R-GGA-434030 TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex BibTex
2009-08-27 R-GGA-433826 Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. BibTex
2009-08-27 R-GGA-433864 IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 BibTex
2009-08-27 R-GGA-434047 phosphorylation of IRAK2 by activated IRAK4 BibTex
2009-08-27 R-GGA-433961 Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 BibTex
2009-08-27 R-GGA-434073 IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 BibTex
2009-08-27 R-GGA-434018 Autophosphorylation of chicken IRAK4 BibTex
2009-08-27 R-GGA-434003 LPS binding to CD14 co-receptor BibTex
2009-08-27 R-GGA-433823 Released NFkB complex migrates to the nucleus and turns on transcription BibTex
2009-08-27 R-GGA-433808 viral dsRNA: TLR3: TICAM1 recruits TRAF6 BibTex
2009-08-27 R-GGA-433981 Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 BibTex
2009-08-27 R-GGA-433936 Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 BibTex
2009-08-27 R-GGA-433950 TRAF6 recruits TAK1 kinase complex BibTex
2009-08-27 R-GGA-433957 Activation of recruited TAK1 BibTex
2009-08-27 R-GGA-434053 TRAF6 binds to p-IRAK2 complexed with activated TLR BibTex
2009-08-27 R-GGA-434084 p-IRAK2- TRAF6 dissociates from the activated chTLR complex BibTex
2009-08-27 R-GGA-433955 Phosphorylation of IKKs complex by activated TAK1 BibTex
2009-08-27 R-GGA-434004 viral dsRNA binds the toll-like receptor 3 (TLR3) BibTex
2009-08-27 R-GGA-433815 viral dsRNA : TRL3 recruits TICAM1 BibTex
2009-08-27 R-GGA-433845 chicken RIP1 facilitates IKKs complex activation BibTex
2009-08-27 R-GGA-433986 activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB BibTex
Cite Us!