Castagnoli, L

Authored Pathways (5/5)
Date Identifier Pathway Reference
2008-02-28 R-HSA-177929 Signaling by EGFR BibTex
2006-10-10 R-HSA-180336 SHC1 events in EGFR signaling BibTex
2006-10-10 R-HSA-179812 GRB2 events in EGFR signaling BibTex
2006-10-10 R-HSA-180292 GAB1 signalosome BibTex
2006-10-10 R-HSA-182971 EGFR downregulation BibTex
Authored Reactions (41/41)
Date Identifier Reaction Reference
2006-10-10 R-HSA-177931 Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 BibTex
2006-10-10 R-HSA-177920 Binding of GRB2 to GAB1 BibTex
2006-10-10 R-HSA-177927 PI3K binds to EGF:EGFR:GRB2:GAB1 BibTex
2006-10-10 R-HSA-177930 GAB1 phosphorylation by EGFR kinase BibTex
2006-10-10 R-HSA-177941 GRB2:GAB1 binds to phosphorylated EGFR BibTex
2006-10-10 R-HSA-179467 GAB1 binds phosphatidylinositol-3,4,5-trisphosphate BibTex
2006-10-10 R-HSA-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) BibTex
2006-10-10 R-HSA-177942 EGFR binds EGF ligand BibTex
2006-10-10 R-HSA-177946 Pro-EGF is cleaved to form mature EGF BibTex
2006-10-10 R-HSA-177922 EGFR dimerization BibTex
2006-10-10 R-HSA-177934 EGFR autophosphorylation BibTex
2006-10-10 R-HSA-177937 Phosphorylation of EGFR by SRC kinase BibTex
2006-10-10 R-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR BibTex
2006-10-10 R-HSA-177933 SHC1 phosphorylation by phosphorylated EGFR BibTex
2006-10-10 R-HSA-177925 SHC1 binds to the phosphorylated EGF receptor:ligand complex BibTex
2006-10-10 R-HSA-177943 GRB2:SOS1 complex binds to EGF:EGFR complex BibTex
2006-10-10 R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) BibTex
2006-10-10 R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) BibTex
2006-10-10 R-HSA-177923 Sustained activation of SRC kinase by SHP2 BibTex
2006-10-10 R-HSA-177926 Dephosphorylation of PAG by SHP2 BibTex
2006-10-10 R-HSA-177944 Activation of SHP2 through the binding to phospho-Gab1 BibTex
2006-10-10 R-HSA-177924 Dephosphorylation of Gab1 by SHP2 BibTex
2006-10-10 R-HSA-177935 SHP2 dephosphorylates Tyr 992 on EGFR BibTex
2006-10-10 R-HSA-182994 Assembly of EGFR complex in clathrin-coated vesicles BibTex
2006-10-10 R-HSA-183072 EGFR non-clathrin mediated endocytosis BibTex
2006-10-10 R-HSA-182986 CBL-mediated ubiquitination of CIN85 BibTex
2006-10-10 R-HSA-183051 CBL ubiquitinates Sprouty BibTex
2006-10-10 R-HSA-8951490 CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 BibTex
2006-10-10 R-HSA-183002 Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 BibTex
2006-10-10 R-HSA-182990 Sprouty sequesters CBL away from active EGFR BibTex
2006-10-10 R-HSA-183055 Binding of CBL to EGFR BibTex
2006-10-10 R-HSA-183052 CBL binds to GRB2 BibTex
2006-10-10 R-HSA-182988 Sprouty lures CBL away from EGFR BibTex
2006-10-10 R-HSA-183084 CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix BibTex
2006-10-10 R-HSA-183058 Phosphorylation of CBL (EGFR:GRB2:CBL) BibTex
2006-10-10 R-HSA-183067 Localization of CBL:GRB2 to the membrane BibTex
2006-10-10 R-HSA-183089 CBL binds and ubiquitinates phosphorylated Sprouty BibTex
2006-10-10 R-HSA-182969 Phosphorylation of CBL (EGFR:CBL) BibTex
2006-10-10 R-HSA-182993 Ubiquitination of stimulated EGFR (CBL) BibTex
2006-10-10 R-HSA-183094 CDC42:GTP binds CBL:Beta-Pix BibTex
2006-10-10 R-HSA-183036 Ubiquitination of stimulated EGFR (CBL:GRB2) BibTex
Reviewed Pathways (15/15)
Date Identifier Pathway Reference
2008-11-06 R-HSA-111997 CaM pathway BibTex
2008-11-06 R-HSA-111933 Calmodulin induced events BibTex
2008-11-06 R-HSA-111957 Cam-PDE 1 activation BibTex
2008-11-06 R-HSA-111931 PKA-mediated phosphorylation of CREB BibTex
2008-11-06 R-HSA-163615 PKA activation BibTex
2008-11-06 R-HSA-111932 CaMK IV-mediated phosphorylation of CREB BibTex
2008-11-06 R-HSA-170670 Adenylate cyclase inhibitory pathway BibTex
2008-11-06 R-HSA-111885 Opioid Signalling BibTex
2008-11-06 R-HSA-112040 G-protein mediated events BibTex
2008-11-06 R-HSA-170660 Adenylate cyclase activating pathway BibTex
2008-11-06 R-HSA-112043 PLC beta mediated events BibTex
2008-11-06 R-HSA-111996 Ca-dependent events BibTex
2008-11-06 R-HSA-111995 phospho-PLA2 pathway BibTex
2008-11-06 R-HSA-180024 DARPP-32 events BibTex
2008-11-06 R-HSA-202040 G-protein activation BibTex
Reviewed Reactions (54/54)
Date Identifier Reaction Reference
2008-11-06 R-HSA-111916 Dimerization of p-S133-CREB1 BibTex
2008-11-06 R-HSA-111879 PIP2 hydrolysis BibTex
2008-11-06 R-HSA-111870 Activation of PLC beta-1/4 BibTex
2008-11-06 R-HSA-111912 CaMK4 phosphorylates CREB1 BibTex
2008-11-06 R-HSA-111915 CAMK4 autophosphorylates BibTex
2008-11-06 R-HSA-111913 Calmodulin binds CAMK4 BibTex
2008-11-06 R-HSA-112282 CAMK4 enters the nucleus BibTex
2008-11-06 R-RNO-379960 Calmodulin binds CaMK IV BibTex
2008-11-06 R-RNO-379832 CaMKIV phosphorylates Creb1 BibTex
2008-11-06 R-HSA-111881 Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase BibTex
2008-11-06 R-HSA-111898 Phosphorylation of cPLA2 by ERK-2 BibTex
2008-11-06 R-RNO-182052 IP3 binds to the IP3 receptor, opening the Ca2+ channel BibTex
2008-11-06 R-RNO-182097 Calcium release from intracellular stores by IP3 receptor activation BibTex
2008-11-06 R-BTA-74447 Calcium binds calmodulin BibTex
2008-11-06 R-HSA-111919 PKA phosphorylates CREB1 BibTex
2008-11-06 R-HSA-111924 PKA catalytic subunit translocates to the nucleus BibTex
2008-11-06 R-HSA-111925 cAMP induces dissociation of inactive PKA tetramers BibTex
2008-11-06 R-HSA-8951727 cAMP binds PKA tetramer BibTex
2008-11-06 R-HSA-111930 Adenylate cyclase produces cAMP BibTex
2008-11-06 R-RNO-379836 PKA catalytic subunit translocates to the nucleus BibTex
2008-11-06 R-NUL-9615367 Prkaca phosphorylates Creb1 BibTex
2008-11-06 R-RNO-379842 Dimerization of p-S133-Creb1 BibTex
2008-11-06 R-HSA-111955 cAMP hydrolysis by Cam-PDE 1 BibTex
2008-11-06 R-HSA-111956 Calmodulin activates Cam-PDE 1 BibTex
2008-11-06 R-HSA-111966 GRK2 binds CALM1:4Ca2+ BibTex
2008-11-06 R-HSA-170674 Dissociation of the Gi alpha:G olf complex BibTex
2008-11-06 R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha BibTex
2008-11-06 R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf BibTex
2008-11-06 R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex BibTex
2008-11-06 R-HSA-167427 Opioid dissociates from MOR BibTex
2008-11-06 R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it BibTex
2008-11-06 R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP BibTex
2008-11-06 R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates BibTex
2008-11-06 R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf BibTex
2008-11-06 R-HSA-112037 Inactivation of PLC beta BibTex
2008-11-06 R-HSA-180038 DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function BibTex
2008-11-06 R-HSA-177275 PKA phosphorylates DARPP-32 on Thr34 BibTex
2008-11-06 R-HSA-201783 Inactive catalytic PP2B is activated by the binding of calmodulin BibTex
2008-11-06 R-BTA-375176 Inactive catalytic PP2B is activated by the binding of calmodulin BibTex
2008-11-06 R-HSA-177284 PKA phosphorylates PDE4B BibTex
2008-11-06 R-HSA-9644869 p-S54-PDE4B hydrolyses cAMP BibTex
2008-11-06 R-HSA-201787 PPP3 complex dephosphorylates DARPP-32 on Thr34 BibTex
2008-11-06 R-RNO-201760 Ppp3 complex dephosphorylates DARPP-32 on T34 BibTex
2008-11-06 R-HSA-111962 PDE4A,C,D hydrolyse cAMP BibTex
2008-11-06 R-HSA-180073 DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function BibTex
2008-11-06 R-HSA-180047 CDK5 phosphorylates DARPP-32 on Thr75 BibTex
2008-11-06 R-HSA-201790 DARPP-32 is dephosphorylated on Thr75 by PP2A BibTex
2008-11-06 R-HSA-112042 Opioid binds MOR BibTex
2008-11-06 R-HSA-167408 The high affinity receptor complex binds to G-protein BibTex
2008-11-06 R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit BibTex
2008-11-06 R-HSA-167415 G-protein alpha subunit is inactivated BibTex
2008-11-06 R-HSA-112271 The receptor:G-protein complex dissociates BibTex
2008-11-06 R-HSA-167429 The receptor:G-protein complex binds GTP BibTex
2008-11-06 R-HSA-167419 The receptor:G-protein complex releases GDP BibTex
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