Carl-Henrik Heldin

Affiliation
Ludwig Institute for Cancer Research, Uppsala Branch
Authored Pathways (1/1)
Date Identifier Pathway Reference
2006-02-02 R-HSA-170834 Signaling by TGF-beta Receptor Complex BibTex
Authored Reactions (22/22)
Date Identifier Reaction Reference
2006-02-02 R-HSA-173488 The SMAD2/3:SMAD4 complex transfers to the nucleus BibTex
2006-02-02 R-HSA-170847 Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 BibTex
2006-02-02 R-HSA-170850 Phosphorylated SMAD2/3 dissociates from TGFBR BibTex
2006-02-02 R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly BibTex
2006-02-02 R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 BibTex
2006-02-02 R-HSA-170843 TGFBR2 phosphorylates TGFBR1 BibTex
2006-02-02 R-HSA-170846 TGFBR2 recruits TGFBR1 BibTex
2006-02-02 R-HSA-170861 Dimeric TGF-beta-1 binds to the receptor BibTex
2006-02-02 R-HSA-173481 SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling BibTex
2006-02-02 R-HSA-173545 Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling BibTex
2006-02-02 R-HSA-177107 Secretion and activation of the latent large complex of TGF-beta-1 BibTex
2006-02-02 R-HSA-170844 Latent TGF-beta-1 is cleaved by FURIN BibTex
2006-02-02 R-HSA-178178 PP1 dephosphorylates TGFBR1 BibTex
2006-02-02 R-HSA-178189 SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR BibTex
2006-02-02 R-HSA-173512 I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) BibTex
2006-02-02 R-NUL-2167890 Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex BibTex
2006-02-02 R-NUL-2167872 PP1CC dephosphorylates TGFBR1 BibTex
2006-02-02 R-HSA-2167917 SMAD7 binds to SMURF1 BibTex
2006-02-02 R-HSA-178208 SMAD7 binds to SMURF2 BibTex
2006-02-02 R-HSA-173542 SMURF2 ubiquitinates SMAD2 BibTex
2006-02-02 R-HSA-178215 SMAD7:SMURF1 complex is exported to the cytosol BibTex
2006-02-02 R-HSA-178218 SMAD7:SMURF complex binds to phosphorylated TGFBR1 BibTex
Reviewed Pathways (10/10)
Date Identifier Pathway Reference
2008-11-24 R-HSA-186763 Downstream signal transduction BibTex
2008-11-24 R-HSA-186797 Signaling by PDGF BibTex
2008-02-28 R-HSA-177929 Signaling by EGFR BibTex
2008-02-12 R-HSA-180336 SHC1 events in EGFR signaling BibTex
2008-02-12 R-HSA-179812 GRB2 events in EGFR signaling BibTex
2008-02-12 R-HSA-180292 GAB1 signalosome BibTex
2008-02-12 R-HSA-182971 EGFR downregulation BibTex
2008-02-12 R-HSA-212718 EGFR interacts with phospholipase C-gamma BibTex
2007-11-12 R-HSA-201451 Signaling by BMP BibTex
2006-04-18 R-HSA-170834 Signaling by TGF-beta Receptor Complex BibTex
Reviewed Reactions (96/96)
Date Identifier Reaction Reference
2008-11-24 R-HSA-186826 GRB2:SOS1 complex binds to the active receptor BibTex
2008-11-24 R-HSA-186786 Autophosphorylation of PDGF beta receptors BibTex
2008-11-24 R-HSA-186773 PDGF dimer binds two receptors simultaneously BibTex
2008-11-24 R-HSA-186785 PDGF-AA clevage by Furin BibTex
2008-11-24 R-HSA-382053 Translocation of PDGF from ER to Golgi BibTex
2008-11-24 R-HSA-8865276 PDGF-AB clevage by Furin BibTex
2008-11-24 R-HSA-8865275 PDGF-BB clevage by Furin BibTex
2008-11-24 R-HSA-389086 Autophosphorylation of PDGF alpha/beta receptors BibTex
2008-11-24 R-HSA-389083 Autophosphorylation of PDGF alpha receptors BibTex
2008-11-24 R-HSA-186780 PI3-kinase binds to the active receptor BibTex
2008-11-24 R-HSA-382054 PDGF binds to extracellular matrix proteins BibTex
2008-11-24 R-HSA-382057 Release of novel PDGFs as latent factors BibTex
2008-11-24 R-HSA-382061 Extracellular processing of novel PDGFs BibTex
2008-11-24 R-HSA-382056 Crk binds to the active PDGF receptor BibTex
2008-11-24 R-HSA-186834 SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) BibTex
2008-11-24 R-HSA-186819 SH2 domain of Src binds to the active receptor BibTex
2008-11-24 R-HSA-380780 Activation of Src BibTex
2008-11-24 R-HSA-380782 STAT binds to the active receptor BibTex
2008-11-24 R-HSA-1524186 Phosphorylation of PLCgamma by PDGFR BibTex
2008-11-24 R-HSA-186765 PLC-gamma binds to the active receptor BibTex
2008-11-24 R-HSA-382058 Nck binds to the active PDGF receptor BibTex
2008-11-24 R-HSA-186800 PI3K catalyses the phosphorylation of PIP2 to PIP3 BibTex
2008-11-24 R-HSA-1524182 Activated PLC gamma dissociates from the PDGF receptor BibTex
2008-11-24 R-HSA-382052 p130Cas and C3G bind PDGFR bound Crk BibTex
2008-11-24 R-HSA-382055 Grb7 binds to the active PDGF receptor BibTex
2008-11-24 R-HSA-186798 GAP binds to PDGF-beta receptors only BibTex
2008-11-24 R-HSA-186778 SHP2 binds to the active receptor BibTex
2008-02-12 R-HSA-177931 Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 BibTex
2008-02-12 R-HSA-177920 Binding of GRB2 to GAB1 BibTex
2008-02-12 R-HSA-177927 PI3K binds to EGF:EGFR:GRB2:GAB1 BibTex
2008-02-12 R-HSA-177930 GAB1 phosphorylation by EGFR kinase BibTex
2008-02-12 R-HSA-177941 GRB2:GAB1 binds to phosphorylated EGFR BibTex
2008-02-12 R-HSA-179467 GAB1 binds phosphatidylinositol-3,4,5-trisphosphate BibTex
2008-02-12 R-HSA-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) BibTex
2008-02-12 R-HSA-212713 Active PLC-gamma1 dissociates from EGFR BibTex
2008-02-12 R-HSA-212710 EGFR activates PLC-gamma1 by phosphorylation BibTex
2008-02-12 R-HSA-212706 Phospholipase C-gamma1 binds to the activated EGF receptor BibTex
2008-02-12 R-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR BibTex
2008-02-12 R-HSA-109813 GRB2-1 binds SOS1 BibTex
2008-02-12 R-HSA-177933 SHC1 phosphorylation by phosphorylated EGFR BibTex
2008-02-12 R-HSA-177925 SHC1 binds to the phosphorylated EGF receptor:ligand complex BibTex
2008-02-12 R-HSA-177943 GRB2:SOS1 complex binds to EGF:EGFR complex BibTex
2008-02-12 R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) BibTex
2008-02-12 R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) BibTex
2008-02-12 R-HSA-177923 Sustained activation of SRC kinase by SHP2 BibTex
2008-02-12 R-HSA-177926 Dephosphorylation of PAG by SHP2 BibTex
2008-02-12 R-HSA-177944 Activation of SHP2 through the binding to phospho-Gab1 BibTex
2008-02-12 R-HSA-177924 Dephosphorylation of Gab1 by SHP2 BibTex
2008-02-12 R-HSA-177935 SHP2 dephosphorylates Tyr 992 on EGFR BibTex
2008-02-12 R-HSA-182994 Assembly of EGFR complex in clathrin-coated vesicles BibTex
2008-02-12 R-HSA-183072 EGFR non-clathrin mediated endocytosis BibTex
2008-02-12 R-HSA-182986 CBL-mediated ubiquitination of CIN85 BibTex
2008-02-12 R-HSA-183051 CBL ubiquitinates Sprouty BibTex
2008-02-12 R-HSA-8951490 CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 BibTex
2008-02-12 R-HSA-183002 Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 BibTex
2008-02-12 R-HSA-182990 Sprouty sequesters CBL away from active EGFR BibTex
2008-02-12 R-HSA-183055 Binding of CBL to EGFR BibTex
2008-02-12 R-HSA-183052 CBL binds to GRB2 BibTex
2008-02-12 R-HSA-182988 Sprouty lures CBL away from EGFR BibTex
2008-02-12 R-HSA-183084 CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix BibTex
2008-02-12 R-HSA-183058 Phosphorylation of CBL (EGFR:GRB2:CBL) BibTex
2008-02-12 R-HSA-183067 Localization of CBL:GRB2 to the membrane BibTex
2008-02-12 R-HSA-183089 CBL binds and ubiquitinates phosphorylated Sprouty BibTex
2008-02-12 R-HSA-182969 Phosphorylation of CBL (EGFR:CBL) BibTex
2008-02-12 R-HSA-182993 Ubiquitination of stimulated EGFR (CBL) BibTex
2008-02-12 R-HSA-183094 CDC42:GTP binds CBL:Beta-Pix BibTex
2008-02-12 R-HSA-183036 Ubiquitination of stimulated EGFR (CBL:GRB2) BibTex
2007-11-12 R-HSA-201472 The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus BibTex
2007-11-12 R-HSA-201422 Phospho-R-Smad1/5/8 forms a complex with Co-Smad BibTex
2007-11-12 R-HSA-201453 Phospho-R-Smad1/5/8 dissociates from the receptor complex BibTex
2007-11-12 R-HSA-201476 Activated type I receptor phosphorylates R-Smad1/5/8 directly BibTex
2007-11-12 R-HSA-201648 An anchoring protein, Endofin, recruits R-Smad1/5/8 BibTex
2007-11-12 R-HSA-201443 Type II receptor phosphorylates type I receptor BibTex
2007-11-12 R-HSA-201457 BMP2 binds to the receptor complex BibTex
2007-11-12 R-HSA-202604 Formation of a heteromeric BMP receptor complex BibTex
2007-11-12 R-HSA-201475 I-Smad competes with R-Smad1/5/8 for type I receptor BibTex
2007-11-12 R-HSA-202626 I-Smad competes with Co-Smad for R-Smad1/5/8 BibTex
2007-11-12 R-HSA-201445 Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 BibTex
2007-11-12 R-HSA-201423 SKI complexes with the Smad complex, suppressing BMP2 signalling BibTex
2007-11-12 R-HSA-201810 The ligand trap binds the ligand BMP2, blocking BMP signalling BibTex
2007-11-12 R-HSA-201425 Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling BibTex
2007-11-12 R-HSA-201821 I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated BibTex
2006-04-18 R-HSA-173488 The SMAD2/3:SMAD4 complex transfers to the nucleus BibTex
2006-04-18 R-HSA-170847 Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 BibTex
2006-04-18 R-HSA-170850 Phosphorylated SMAD2/3 dissociates from TGFBR BibTex
2006-04-18 R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly BibTex
2006-04-18 R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 BibTex
2006-04-18 R-HSA-170843 TGFBR2 phosphorylates TGFBR1 BibTex
2006-04-18 R-HSA-170846 TGFBR2 recruits TGFBR1 BibTex
2006-04-18 R-HSA-170861 Dimeric TGF-beta-1 binds to the receptor BibTex
2006-04-18 R-HSA-173481 SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling BibTex
2006-04-18 R-HSA-173545 Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling BibTex
2006-04-18 R-HSA-177107 Secretion and activation of the latent large complex of TGF-beta-1 BibTex
2006-04-18 R-HSA-170844 Latent TGF-beta-1 is cleaved by FURIN BibTex
2006-04-18 R-HSA-173512 I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) BibTex
2006-04-18 R-HSA-173542 SMURF2 ubiquitinates SMAD2 BibTex
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