Search results for ACOT8

Showing 5 results out of 5

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Species

Types

Compartments

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Protein (2 results from a total of 2)

Identifier: R-HSA-193426
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: ACOT8: O14734
Identifier: R-HSA-9033134
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: ACOT8: O14734

Reaction (3 results from a total of 3)

Identifier: R-HSA-390304
Species: Homo sapiens
Compartment: peroxisomal matrix
Peroxisomal ACOT8 catalyzes the hydrolysis of acetyl-CoA to form acetate and CoASH (Jones et al. 1999; Wanders and Waterham 2006).
Identifier: R-HSA-193385
Species: Homo sapiens
Compartment: peroxisomal matrix
The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).
Identifier: R-HSA-2066779
Species: Homo sapiens
Compartment: peroxisomal matrix
DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).
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