Search results for APH1B

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Protein (2 results from a total of 2)

Identifier: R-HSA-157340
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: APH1B: Q8WW43
Identifier: R-HSA-9010060
Species: Homo sapiens
Compartment: endosome membrane
Primary external reference: UniProt: APH1B: Q8WW43

Reaction (1 results from a total of 1)

Identifier: R-HSA-193682
Species: Homo sapiens
Compartment: plasma membrane, early endosome
Within early endosomes, p75NTR C-Terminal Fragment undergoes processing by gamma-secretase, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such a minimal complex is sufficient for secretase activity, although other components may exist. The p75NTR cleavage by gamma-secretase gives rise to a 20-kD ICD (IntraCellular Domain) fragment, and to a small peptide, the significance of which is unknown but that is analogous to the A-beta peptides generated from amyloid precursor protein. p75NTR ICD may have cytoplasmic and nuclear signalling functions and it is unstable.
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