Search results for BCL6

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Reaction (5 results from a total of 5)

Identifier: R-HSA-6800250
Species: Homo sapiens
Compartment: nucleoplasm
Binding of TP53 (p53) to the p53 response element in the first intron of the BCL6 gene promotes BCL6 transcription (Margalit et al. 2006). BCL6 is a transcriptional repressor that has been implicated as a facilitator of apoptosis, through inhibition of BCL2 expression (Saito et al. 2009), but also as an inhibitor of apoptosis, through inhibition of TP53 expression (Phan and Dalla-Favera 2004).
Identifier: R-HSA-6800253
Species: Homo sapiens
Compartment: nucleoplasm
TP53 (p53) binds the p53 response element located in the first intron of the BCL6 gene. This region of the BCL6 gene is frequently subject to translocations, point mutations and deletions in B-cell non-Hodgkin lymphoma (Margalit et al. 2006).
Identifier: R-HSA-9622627
Species: Homo sapiens
Compartment: nucleoplasm
Transcription of the BCL6 gene, encoding a pro-apoptotic transcriptional repressor, is directly stimulated by FOXO3 (Fernandez de Mattos et al. 2004) and FOXO4 (AFX) (Tang et al. 2002). FOXO1 stimulates BCL6 gene transcription (Shore et al. 2006), but direct binding of FOXO1 to the BCL6 gene promoter has not been demonstrated.
Identifier: R-HSA-9622630
Species: Homo sapiens
Compartment: nucleoplasm
FOXO3 (Fernandez de Mattos et al. 2004), FOXO4 (AFX) (Tang et al. 2002), and probably FOXO1 (Shore et al. 2006) bind to forkhead box elements in the promoter of the BCL6 gene.
Identifier: R-HSA-6790036
Species: Homo sapiens
Compartment: nucleoplasm
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for nuclear proteins upregulated by STAT3 include CCAAT/enhancer-binding protein delta (CEBPD) (Hutt et al. 2000), B-cell lymphoma 6 protein (BCL6) (Reljic et al. 2000), Myc proto-oncogene protein (MYC) (Kiuchi et al. 1999, Bowman et al. 2001), Proto-oncogene c-Fos (FOS) (Yang et al. 2003), Hypoxia-inducible factor 1-alpha (HIF1A) (Niu et al. 2008), Transcription factor SOX-2 (SOX2) (Foshay & Gallicano 2008), the homeobox protein NANOG (Okumura et al. 2011), Twist-related protein 1 (TWIST1) (Lo et al. 2007, Cheng et al. 2008), Zinc finger E-box-binding homeobox 1 (ZEB1) (Xiong et al. 2012), POU domain, class 2, transcription factor 1 (POU2F1) (OCT1) (Wang et al. 2013), Baculoviral IAP repeat-containing protein 5 (BIRC5, Survivin) (Gritsko et al. 2006), G1/S-specific cyclin-D1 (CCND1) (Leslie et al. 2006), Serine/threonine-protein kinase PIM1 (Przanowski et al. 2014), Forkhead box protein O1 (FOXO1), FOXO3 (Oh et al. 2011), Nuclear receptor ROR-alpha (RORA), RORC, Basic leucine zipper transcriptional factor ATF-like (BATF) (Durant et al. 2010) and Transcription factor JUNB (Coffer et al. 1995).
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