Search results for CTH

Showing 11 results out of 12

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Species

Types

Compartments

Reaction types

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Protein (1 results from a total of 1)

Identifier: R-HSA-1614606
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: CTH: P32929

Complex (1 results from a total of 1)

Identifier: R-HSA-1625212
Species: Homo sapiens
Compartment: cytosol

Reaction (7 results from a total of 8)

Identifier: R-HSA-1614583
Species: Homo sapiens
Compartment: cytosol
Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH). CTH utilises pyridoxal 5'-phosphate (PXLP) as cofactor (Chiku et al. 2009, Steegborn et al. 1999).
Identifier: R-HSA-2408543
Species: Homo sapiens
Compartment: cytosol
Cystathionine gamma-lyase (CTH) homotetramer is involved in the hydrolysis of selenocystathionine (SeCysta) into selenocysteine (Sec), ammonia and 2-oxobutanoic acid by an alpha,gamma-elimination reaction. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) homotetramer (Esaki et al. 1981).
Identifier: R-HSA-2408539
Species: Homo sapiens
Compartment: cytosol
Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).
Identifier: R-HSA-2408537
Species: Homo sapiens
Compartment: cytosol
Excess selenomethionine (SeMet) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and 2-oxobutanoic acid. This reaction is inferred from the event in mouse involving the protein cystathionine gamma-lyase (Cth) (Okuno et al. 2001, Okuno et al. 2005, Okuno et al. 2006).
Identifier: R-HSA-1614591
Species: Homo sapiens
Compartment: cytosol
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Identifier: R-HSA-1614614
Species: Homo sapiens
Compartment: cytosol
alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).
Identifier: R-HSA-1614631
Species: Homo sapiens
Compartment: cytosol
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Pathway (2 results from a total of 2)

Identifier: R-HSA-2408508
Species: Homo sapiens
Inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).
Identifier: R-HSA-2408522
Species: Homo sapiens
Selenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulphur share many chemical properties and so the substitution of normal amino acids with selenoamino acids has little effect on protein structure and function. Both inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can be introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) and then utilized for the de novo synthesis of Sec through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of Sec formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

All nutritional selenium is metabolised into selenide directly or through methylselenol (MeSeH). Sec liberated from selenoproteins is transformed to Se(2-) by selenocysteine lyase (SCLY). SeMet liberated from general proteins and from free SeMet sources is transformed into Se(2-) either through MeSeH by cystathionine gamma-lyase (CTH) followed by demethylation (SeMet to CH3SeH to H2Se), or through Sec by SCLY after the trans-selenation pathway (SeMet to Sec to H2Se). MeSec is hydrolysed into MeSeH by CTH. Methylseleninic acid (MeSeO2H) is reduced to methylselenol. MeSeH is demethylated to Se(2-) for further utilization for selenoprotein synthesis or oxidised to selenite (SeO3(2-)) for excretion in the form of selenosugar. Additionally, MeSeH is further methylated to dimethylselenide (Me2Se) and trimethylselenonium (Me3Se+) for excretion.
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