Search results for CYP19A1

Showing 10 results out of 10

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Protein (5 results from a total of 5)

Identifier: R-HSA-193137
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: CYP19A1: P11511
Identifier: R-HSA-5601972
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P11511
Identifier: R-HSA-5601971
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P11511
Identifier: R-HSA-5601981
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P11511
Identifier: R-HSA-5601978
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: P11511

Set (1 results from a total of 1)

Identifier: R-HSA-5601941
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane

Reaction (3 results from a total of 3)

Identifier: R-HSA-193060
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of androstenedione (ANDST) to estrone (E1) is catalysed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane (Toda et al. 1990, Simpson et al. 1994).
Identifier: R-HSA-193143
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of testosterone to estradiol is catalyzed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane.
Identifier: R-HSA-5601849
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Aromatase (CYP19A1) catalyses the conversion of androstenedione (ANDST) to estrone (E1). Defects in CYP19A1 can cause aromatase excess syndrome (AEXS; MIM:139300) and aromatase deficiency (AROD; MIM:613546). Affected individuals cannot synthesise endogenous estrogens. In females the lack of estrogen leads to pseudohermaphroditism and progressive virilization at puberty, whereas in males pubertal development is normal. Mutations causing AEXS include C437Y, R375C, R365Q and E210K (Ito et al. 1993, Morishima et al. 1995, Carani et al. 1997, Maffei et al. 2004).

Pathway (1 results from a total of 1)

Identifier: R-HSA-5579030
Species: Homo sapiens
Aromatase (CYP19A1) catalyses the conversion of androstenedione (ANDST) to estrone (E1). Defects in CYP19A1 can cause aromatase excess syndrome (AEXS; MIM:139300) and aromatase deficiency (AROD; MIM:613546). Affected individuals cannot synthesise endogenous estrogens. In females the lack of estrogen leads to pseudohermaphroditism and progressive virilization at puberty, whereas in males pubertal development is normal (Bulun 2014).
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