Search results for CYP19A1

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Reaction (3 results from a total of 3)

Identifier: R-HSA-193060
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of androstenedione (ANDST) to estrone (E1) is catalysed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane (Toda et al. 1990, Simpson et al. 1994).
Identifier: R-HSA-193143
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The conversion of testosterone to estradiol is catalyzed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane.
Identifier: R-HSA-5601849
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Aromatase (CYP19A1) catalyses the conversion of androstenedione (ANDST) to estrone (E1). Defects in CYP19A1 can cause aromatase excess syndrome (AEXS; MIM:139300) and aromatase deficiency (AROD; MIM:613546). Affected individuals cannot synthesise endogenous estrogens. In females the lack of estrogen leads to pseudohermaphroditism and progressive virilization at puberty, whereas in males pubertal development is normal. Mutations causing AEXS include C437Y, R375C, R365Q and E210K (Ito et al. 1993, Morishima et al. 1995, Carani et al. 1997, Maffei et al. 2004).
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