Search results for CYP2A13

Showing 4 results out of 4

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-211034
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: CYP2A13: Q16696

Reaction (2 results from a total of 2)

Identifier: R-HSA-211881
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum
CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.
Identifier: R-HSA-5423647
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Cytochrome P450 2A13 is able to oxidise aflatoxin M1 (AFM1) to the reactive aflatoxin M1 epoxide (AFM1E) (He et al. 2006). AFM1E is less carcinogenic or mutagenic than aflatoxin B1-exo-8,9-epoxide (AFBO), but is equally toxic. AFM1E would usually be detoxified by conjugation with glutathione, eventually excreted in urine as a mercapturic acid (not shown here).

Set (1 results from a total of 1)

Identifier: R-HSA-3222449
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
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