Search results for EPHX2

Showing 5 results out of 5

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Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-2142819
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: EPHX2: P34913
Identifier: R-HSA-9033088
Species: Homo sapiens
Compartment: peroxisomal matrix
Primary external reference: UniProt: P34913

Complex (1 results from a total of 1)

Identifier: R-HSA-2142777
Species: Homo sapiens
Compartment: cytosol

Reaction (2 results from a total of 2)

Identifier: R-HSA-2161961
Species: Homo sapiens
Compartment: cytosol
Epoxide hydrolase 2 (EPHX2) hydrolyses 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids ("EET(1)") to their corresponding dihydroxyeicosatrienoic acids ("DHET(1)") (Werner et al. 2002; Gomez et al. 2004). The majority of the EET biological activities are diminished by this hydrolysis.
Identifier: R-HSA-9024993
Species: Homo sapiens
Compartment: cytosol
Dimeric bifunctional epoxide hydrolase 2 (EPHX2 dimer, soluble epoxide hydrolase, sEH) hydrolyses 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form 13(R),14(S)-dihydroxy-docosahexaenoic acid, aka maresin 2 (MaR2) (Deng et al. 2014). Like MaR1, MaR2 possesses anti-inflammatory and pro-resolving activities although it is not as potent as MaR1 (Deng et al. 2014).
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