Search results for ETS2

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Reaction (3 results from a total of 8)

Identifier: R-HSA-3209098
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Phosphorylated ETS1 and ETS2 stimulate p16INK4A transcription, resulting in cell cycle arrest with arrested cells exhibiting high p16INK4A level and senescence-associated beta-galactosidase activity. It is possible that ETS2 is the main transmitter of RAS signaling to p16INK4A at the initiation of the senescence program, and that ETS1 maintains high p16INK4A level once the senescence is already established (Ohtani et al. 2001).
Identifier: R-HSA-3209159
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Phosphorylation of ERF at threonine T526 by activated ERKs triggers ERF export from the nucleus to the cytosol (Le Gallic et al. 2004), which is expected to relieve ERF-mediated inhibition of ETS2 transcription.
Identifier: R-HSA-3200023
Species: Homo sapiens
Compartment: nucleoplasm
ETS1 and ETS2, activated by RAS/RAF/MAP kinase cascade, bind the promoter of p16INK4A in the CDKN2A locus (Ohtani et al. 2001). CDKN2A locus also encodes p14ARF (p19ARF in mouse), but from a different promoter and in a different reading frame. While p16INK4A and p14ARF use different exon 1, (exon 1-alpha and exon 1-beta, respectively), they share exons 2 and 3. However, because the reading frames are different, there is no amino acid sequence similarity between the two proteins (Quelle et al. 1995).
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