Search results for ETS2

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Reaction (8 results from a total of 8)

Identifier: R-HSA-3132737
Species: Homo sapiens
Compartment: nucleoplasm
Both ETS1 and ETS2 contain a consensus site (PLLTP) for MAPK3 and MAPK1 (ERK1 and ERK2, respectively) in the vicinity of the pointed domain, while the pointed domain contains a docking site needed for ERK1/2 binding to ETS1/2. ETS1 and ETS2 are able to collaborate with RAS in superactivating the promoters that contain RREs (RAS response elements) that include ETS-binding sites. The cooperation of ETS1 and ETS2 with RAS activation is dependent on the phosphorylation of PLLTP threonine residue (T38 in ETS1; T72 in ETS2) (Yang et al. 1996, Seidel et al. 2002). Phosphorylation of ETS1 and ETS2 by ERK1/2 induces a conformational change that increases their affinity for the TAZ domain of the transcriptional coactivator CREBBP (CBP) and the transcriptional activation of RREs (Foulds et al. 2004, Nelson et al. 2010), although ETS1/ETS2 may interact with CREBBP in the absence of phosphorylation (Jayaraman et al. 1999). Phosphorylation of serine residue S41 of ETS1 (corresponds to serine residue S75 of ETS2) may be necessary for full activation of ETS1/2 (Nelson et al. 2010).
Identifier: R-HSA-3209179
Species: Homo sapiens
Compartment: nucleoplasm
Binding of ERF to ETS2 promoter strongly represses ETS2 transcription (Sgouras et al. 1995).
Identifier: R-HSA-3209165
Species: Homo sapiens
Compartment: nucleoplasm
Binding of ID1 to ETS2 inhibits ETS2-mediated activation of p16INK4A transcription (Ohtani et al. 2001).
Identifier: R-HSA-3209177
Species: Homo sapiens
Compartment: nucleoplasm
ERF binds to an ETS-binding site in the ETS2 promoter (Sgouras et al. 1995). Phosphorylation of ERF by activated MAPK1 (ERK2) or MAPK3 (ERK1) interferes with ERF-mediated upregulation of ETS2 (Le Gallic et al. 2004).
Identifier: R-HSA-8979082
Species: Homo sapiens
Compartment: nucleoplasm
ETS2, activated by RAS/RAF/MAP kinase cascade, binds the promoter of p16INK4A in the CDKN2A locus (Ohtani et al. 2001). CDKN2A locus also encodes p14ARF (p19ARF in mouse), but from a different promoter and in a different reading frame. While p16INK4A and p14ARF use different exon 1, (exon 1-alpha and exon 1-beta, respectively), they share exons 2 and 3. However, because the reading frames are different, there is no amino acid sequence similarity between the two proteins (Quelle et al. 1995).
Identifier: R-HSA-3209098
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Phosphorylated ETS1 and ETS2 stimulate p16INK4A transcription, resulting in cell cycle arrest with arrested cells exhibiting high p16INK4A level and senescence-associated beta-galactosidase activity. It is possible that ETS2 is the main transmitter of RAS signaling to p16INK4A at the initiation of the senescence program, and that ETS1 maintains high p16INK4A level once the senescence is already established (Ohtani et al. 2001).
Identifier: R-HSA-3209159
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Phosphorylation of ERF at threonine T526 by activated ERKs triggers ERF export from the nucleus to the cytosol (Le Gallic et al. 2004), which is expected to relieve ERF-mediated inhibition of ETS2 transcription.
Identifier: R-HSA-3200023
Species: Homo sapiens
Compartment: nucleoplasm
ETS1 and ETS2, activated by RAS/RAF/MAP kinase cascade, bind the promoter of p16INK4A in the CDKN2A locus (Ohtani et al. 2001). CDKN2A locus also encodes p14ARF (p19ARF in mouse), but from a different promoter and in a different reading frame. While p16INK4A and p14ARF use different exon 1, (exon 1-alpha and exon 1-beta, respectively), they share exons 2 and 3. However, because the reading frames are different, there is no amino acid sequence similarity between the two proteins (Quelle et al. 1995).
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