Search results for FST

Showing 10 results out of 10

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Species

Types

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Protein (7 results from a total of 7)

FST

Identifier: R-HSA-2473211
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: FST: P19883
Identifier: R-HSA-8956703
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: FSTL3: O95633
Identifier: R-HSA-8956749
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: FSTL1: Q12841
Identifier: R-HSA-8957089
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: Q12841
Identifier: R-HSA-8956915
Species: Homo sapiens
Compartment: endoplasmic reticulum lumen
Primary external reference: UniProt: O95633
Identifier: R-HSA-201832
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: FSTL1: Q12841
Identifier: R-HSA-2473199
Species: Homo sapiens
Compartment: extracellular region
Primary external reference: UniProt: FSTL3: O95633

Reaction (2 results from a total of 2)

Identifier: R-HSA-2473184
Species: Homo sapiens
Compartment: extracellular region
Two molecules of Follistatin (FST) bind an Activin dimer in serum or follicular fluid (Schneyer et al. 1992, Krummen et al. 1993, Schneyer et al. 1994, Thompson et al. 2005). FST has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FST to Activin AB is inferred.
Identifier: R-HSA-2473186
Species: Homo sapiens
Compartment: extracellular region
Two molecules of FSTL3 bind an Activin dimer (Sidis et al. 2002, Stamler et al. 2008). FSTL3 has been experimentally shown to bind Activin A and Activin B (Schneyer et al. 2003). Binding of FSTL3 to Activin AB is inferred. A portion of FSTL3 is also located in the nucleus (Tortoriello et al. 2001), however FSTL3:Activin complexes have not been demonstrated in the nucleus.

Pathway (1 results from a total of 1)

Identifier: R-HSA-2473224
Species: Homo sapiens
Compartment: extracellular region
Both Follistatin (FST) and Follistatin-like-3 (FSTL3) irreversibly bind Activin dimers and prevent Activin from interacting with its receptor (reviewed in Schneyer et al. 2004, Xia and Schneyer 2009). Though functionally similar in vitro, FST and FSTL3 do not function identically in vivo. Mice lacking FST die shortly after birth due to defects in muscle and bone (Matzuk et al. 1995); mice lacking FSTL3 are viable but have altered glucose metabolism (Mukherjee et al. 2007).
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