Search results for GNAS

Showing 3 results out of 3

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Reaction (3 results from a total of 3)

Identifier: R-HSA-8964287
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Upon autophosphorylation, SRC dissociates from GNAS and is subsequently activated. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.
Identifier: R-HSA-8964252
Species: Homo sapiens
Compartment: plasma membrane
G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAS) can directly bind to SRC. In the presence of active GNAS, SRC can autophosphorylate the 416-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer. GNAS increases SRC enzymatic activity by decreasing Km and not affecting Vm.
Identifier: R-HSA-8964278
Species: Homo sapiens
Compartment: cytosol, plasma membrane
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(s) subunit alpha (GNAS) can bind directly to proto-oncogene tyrosine-protein kinase Src (SRC) in vitro and in vivo. This binding results in autophosphorylation of SRC and subsequently its activation. Physiologically, the SRC family have implications in cell growth and cancer.
Cite Us!