HOXA11 (or HOXC11 or HOXD11), EYA1, and PAX2 physically associate to form a complex which binds upstream of the transcription start site of the SIX2 gene (inferred from mouse homologs). In mice, Hoxa11, Eya1 and Pax2 are individually unable to activate Six2 expression (Gong et al. 2007).
HOXA11 (or HOXC11 or HOXD11) , EYA1, and PAX2 physically interact to form a complex (inferred from mouse homologs) which binds the GDNF gene (inferred from mouse Hox11:Eya1:Pax2 binding the Six2 gene in Gong et al. 2007). The components of the HOX11:EYA1:PAX2 complex synergistically activate expression of GDNF (inferred from the mouse homologs).
Hoxa11 (or Hoxc11 or Hoxd11), Eya1, and Pax2 physically associate to form a complex which binds about 450 bp upstream of the transcription start site of the Six2 gene (Gong et al. 2007). The region contains a consensus Hox binding site and a consensus Pax2 binding site (Gong et al. 2007). Hoxa11, Eya1 and Pax2 are individually unable to activate Six2 expression (Gong et al. 2007).
Hoxa11 (or Hoxc11 or Hoxd11), Eya1, and Pax2 physically interact to form a complex (Gong et al. 2007) which binds the Gdnf gene (inferred from results with the Six2 gene in Gong et al. 2007). The components of the Hox11:Eya1:Pax2 complex synergistically activate expression of Gdnf (Gong et al. 2007).