Search results for LMO2

Showing 6 results out of 6

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Species

Types

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Protein (1 results from a total of 1)

Identifier: R-HSA-8956513
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: LMO2: P25791

Interactor (1 results from a total of 1)

Identifier: P25791-3
Species: Homo sapiens
Primary external reference: UniProt: P25791-3

Set (1 results from a total of 1)

Identifier: R-HSA-8956531
Species: Homo sapiens
Compartment: nucleoplasm

Reaction (3 results from a total of 3)

Identifier: R-HSA-5661115
Species: Homo sapiens
Compartment: nucleoplasm
All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine epsilon-amine group and consequently JmjC containing demethylases are able to catalyse demethylateion of tri , di and monomethylated lysines. KDM3A (JHDM2A), KDM3B (JHDM2B), KDM7A (JHDM1D), PHF8 (JHDM1E) and PHF2 when complexed with ARID5B (Wen et al. 2010, Baba et al. 2011) are specific for mono or di-methylated lysine-10 on histone H3 (H3K9Me1/2) (Yamane et al. 2006, Kim et al. 2012, Horton et al. 2010, Huang et al. 2010, Loenarz et al. 2008, Feng et al. 2010, Fortschegger et al. 2010, Qi et al. 2010).
Identifier: R-HSA-4724284
Species: Homo sapiens
Compartment: nucleoplasm
All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine epsilon-amine group and consequently JmjC containing demethylases are able to catalyse demethylateion of tri , di and monomethylated lysines. KDM3A (JHDM2A), KDM3B (JHDM2B), KDM7A (JHDM1D), PHF8 (JHDM1E) and PHF2 when complexed with ARID5B (Wen et al. 2010, Baba et al. 2011) are specific for mono or di-methylated lysine-10 on histone H3 (H3K9Me1/2) (Yamane et al. 2006, Kim et al. 2012, Horton et al. 2010, Huang et al. 2010, Loenarz et al. 2008, Feng et al. 2010, Fortschegger et al. 2010, Qi et al. 2010).
Identifier: R-HSA-8956568
Species: Homo sapiens
Compartment: nucleoplasm
RUNX1, in complex with CBFB, binds to the core TAL1 complex consisting of TAL1 (SCL), TCF3 (E2A) or TCF12 (HEB), LMO1 or LMO2, LDB1 and GATA1, GATA2 or GATA3 (Wilson et al. 2010, Tijssen et al. 2011, Sanda et al. 2012, Mansour et al. 2014, Hoang et al. 2016). Assembly of the RUNX1- and GATA3-containing TAL1 complex is positively regulated by the CDK7-containing CAK complex (Kwiatkowski et al. 2014).
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