Search results for MTR

Showing 9 results out of 51

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Protein (3 results from a total of 12)

Identifier: R-HSA-3318640
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTRR: Q9UBK8
Identifier: R-HSA-3318641
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTRR: Q9UBK8
Identifier: R-HSA-3321943
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MTRR: Q9UBK8

Reaction (3 results from a total of 12)

Identifier: R-HSA-6786854
Species: Homo sapiens
Compartment: mitochondrial matrix
RNase P, ELAC2, and additional unknown nucleases cleave L strand transcripts to release the tRNAs and an mRNA contained in the long polycistronic transcripts.
Mitochondrial RNase P, comprising 3 protein subunits and no RNA moiety (Holzmann et al. 2008), endonucleolytically cleaves polycistronic mitochondrial transcripts at the 5' ends of the tRNA sequences (Sanchez et al. 2011, Howard et al. 2012, Vilardo et al. 2012, Li et al. 2015, Reinhard et al. 2015, Vilardo and Rossmanith 2015). A subcomplex of RNase P also functions as a tRNA methyltransferase and the SDR5C1 subunit is an amino acid and fatty acid dehydrogenase. Mutations in the SDR5C1 subunit of RNase P cause HSD10 disease, which is characterized by progressive neurodegeneration and cardiomyopathy (Vilardo and Rossmanith 2015)
ELAC2 cleaves polycistronic mitochondrial transcripts at the 3' ends of the tRNA sequences (Brzezniak et al. 2011, Sanchez et al. 2011). Different isoforms of ELAC2 are present in the nucleus and mitochondria (Rossmanith 2011). Mutations in ELAC2 cause cardiac hypertrophy (Haack et al. 2013).
Unknown nucleases also cleave the L strand transcript at a site 3' to MT-ND6 (reviewed in Van Haute et al. 2015).
Identifier: R-HSA-6785722
Species: Homo sapiens
Compartment: mitochondrial matrix
RNase P, ELAC2, and additional unknown nucleases cleave H strand transcripts to release the various tRNAs, rRNAs, and mRNAs contained in the long polycistronic transcripts.
Mitochondrial RNase P, comprising 3 protein subunits and no RNA moiety (Holzmann et al. 2008), endonucleolytically cleaves polycistronic mitochondrial transcripts at the 5' ends of the tRNA sequences (Sanchez et al. 2011, Howard et al. 2012, Vilardo et al. 2012, Li et al. 2015, Reinhard et al. 2015, Vilardo and Rossmanith 2015). A subcomplex of RNase P also functions as a tRNA methyltransferase and the SDR5C1 subunit is an amino acid and fatty acid dehydrogenase. Mutations in the SDR5C1 subunit of RNase P cause HSD10 disease, which is characterized by progressive neurodegeneration and cardiomyopathy (Vilardo and Rossmanith 2015)
ELAC2 cleaves polycistronic mitochondrial transcripts at the 3' ends of the tRNA sequences (Brzezniak et al. 2011, Sanchez et al. 2011). Different isoforms of ELAC2 are present in the nucleus and mitochondria (Rossmanith 2011). Mutations in ELAC2 cause cardiac hypertrophy (Haack et al. 2013) and disorders of oxidative phosphorylation (reviewed in Van Haute et al. 2015).
Unknown nucleases also cleave the H strand transcript at sites 5' to MT-CO3, 5' to MT-CO1, and 5' to MT-CYB (reviewed in Van Haute et al. 2015).
Identifier: R-HSA-9018758
Species: Homo sapiens
Compartment: plasma membrane, cytosol
RHOH plays an important role in development of T lymphocytes and binds to several kinases involved in T lymphocyte activation, including:
ZAP70 (Gu et al. 2006, Chae et al. 2010, Wang et al. 2011)
LCK (Chae et al. 2010, Wang et al. 2011)
CSK (Wang et al. 2010).

Additional RHOH interactors include:
PAK1 (Wang et al. 2010; Tajadura Ortega et al. 2018)
PAK2 (Tajadura Ortega et al. 2018)
PAK4 (Tajadura Ortega et al. 2018)
PAK5 (Wu and Frost 2006; Tajadura Ortega et al. 2018)
PAK6 (Tajadura Ortega et al. 2018)

The following RHOH interactors have only been reported in a high throughput screen by Bagci et al. 2020, and are therefore annotated as candidate RHOH effectors:
CAV1 (Bagci et al. 2020).
DBN1 (Bagci et al. 2020)
DBT (Bagci et al. 2020)
FAM91A1 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MTR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
NSFL1C (Bagci et al. 2020)
OSBPL11 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RALGAPA1 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TUBA1B (Bagci et al. 2020)
UACA (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VCP (Bagci et al. 2020)
WDR11 (Bagci et al. 2020)

Complex (3 results from a total of 16)

Identifier: R-HSA-3149516
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9013252
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-3149497
Species: Homo sapiens
Compartment: cytosol
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