Search results for NFATC1

Showing 12 results out of 12

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Protein (3 results from a total of 3)

Identifier: R-HSA-2025953
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: NFATC1: O95644
Identifier: R-HSA-2025935
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: O95644
Identifier: R-HSA-2685618
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: O95644

Complex (3 results from a total of 3)

Identifier: R-HSA-4551448
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-4551463
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-2025899
Species: Homo sapiens
Compartment: cytosol

Reaction (4 results from a total of 4)

Identifier: R-HSA-4551465
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
Dephosphorylated NFAT-calcineurin (CaN) complex translocates to nucleus, where it activates transcription (Okamura et al, 2000; Demjek et al, 2006; Saneyoshi et al, 2002; reviewed in Hogan et al, 2003).
Identifier: R-HSA-2025890
Species: Homo sapiens
Compartment: cytosol
Calcium activates calcineurin in two ways: binding the regulatory subunit of calcineurin directly and binding calmodulin which then interacts with the catalytic subunit of calcineurin. As inferred from mouse, B lymphocytes contain the R1 regulatory subunit (PPP3R1) and the beta catalytic subunit (PPP3CB).
In the presence of calcium and calcium:calmodulin calcineurin binds phosphorylated and unphosphorylated NFATs at 2 regions in the N-terminus (Luo et al. 1996, Garcia-Cozar et al. 1998, Park et al. 2000, evidence from mouse in Loh et al. 1996 and Wesselborg et al. 1996). Calcineurin also weakly interacts with NFATs in the absence of calcium (Garcia-Cozar et al. 1998).
Identifier: R-HSA-2025882
Species: Homo sapiens
Compartment: cytosol, nucleoplasm
As inferred from mouse (Okamura et al. 2000), calcineurin dephosphorylates NFATC2 at 13 serine residues (Batiuk et al. 1997, Kim et al. 2000). B lymphocytes also contain NFATC2 and NFATC3 which are inferred to undergo dephosphorylation at homologous serines. Dephosphorylation of NFATs exposes a nuclear localization signal which cause NFATs to be imported into the nucleus (Kim et al. 2000). In mouse, Calcineurin is observed to also transit into the nucleus in a complex with NFATs and may remain associated (Shibasaki et al. 1996).
Identifier: R-HSA-5692315
Species: Homo sapiens
Compartment: plasma membrane
T-cell activation is mediated not only by antigen stimulation through T-cell receptors but also by costimulatory signals through costimulatory molecules. Among several costimulatory molecules, the tumor necrosis factor (TNF) receptor family member OX40 (also known as TNFRSF4 or CD134) plays a key role in the survival and homeostasis of effector and memory T cells (Godfrey et al. 1994, Kashiwakura et al. 2004, Zingoni et al. 2004). OX40 mediates this costimulation by binding to its partner OX40L (also known as TNFSF4 or CD252). OX40 is a type I transmembrane protein expressed predominantly on T-lymphocytes early after antigen activation. It binds with OX40L trimer expressed on activated antigen presenting cells and endothelial cells within acute inflammatory environments. OX40 mediates signalling independently and also can augment antigen-driven TCR signalling. OX40 signalling leads to the activation of NFkB1 (p50-RELA) to stimulate survival signals to T cells in the absence of antigen recognition. It can also activate hence to activation of noncanonical NF-κB2 (p52-RELB) through NIK which might also be necessary for transmitting survival signals (Kawamata et al. 1998, Arch et al. 1998). OX40 can also enhance TCR-induced calcium influx, leading to strong nuclear accumulation of NFATc1 and NFATc2 that likely regulate production of cytokines (So et al. 2006, Croft 2010).

Set (2 results from a total of 2)

Identifier: R-HSA-2025924
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-2025852
Species: Homo sapiens
Compartment: nucleoplasm
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