Search results for NR3C2

Showing 17 results out of 22

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Protein (6 results from a total of 11)

Identifier: R-HSA-5618122
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: NR3C2: P08235
Identifier: R-HSA-4341124
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P08235
Identifier: R-HSA-3196153
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR3C2: P08235-3
Identifier: R-HSA-3196178
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR3C2: P08235-4
Identifier: R-HSA-3196183
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR3C2: P08235-2
Identifier: R-HSA-3008717
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR3C2: P08235-1

Set (2 results from a total of 2)

Identifier: R-ALL-9027520
Compartment: cytosol
Identifier: R-ALL-9035360
Compartment: nucleoplasm

Reaction (2 results from a total of 2)

Identifier: R-HSA-5618099
Species: Homo sapiens
Compartment: cytosol
Steroid hormones receptors (SHRs) are intracellular transcription factors that can be activated by binding specific ligands (i.e., steroid hormones (SH)) to the ligand-binding domain (LBD) (Ray DW et AL. 1999; Pike AC et al. 1999; Bledsoe RK et al. 2002; Li Y et al. 2005; Kumar R and McEwan IJ 2012; Kumar R et al. 2011; Williams SP & Sigler PB 1998; Tanenbaum DM et al. 1998; Lusher SJ et al. 2012). LBD (E-region) resides in the C-terminal half of the receptor and in addition to ligand binding function contains a transcriptional activation function (AF2), sequences for dimerization, heat shock protein association, intermolecular silencing and intramolecular repression (Kumar R and McEwan IJ 2012). The binding of hormone acts as an allosteric switch to regulate SHR-DNA and SHR-protein interactions, including interdomain interactions and/or dimerization (Kumar R and McEwan IJ 2012).

SHs are synthesized from cholesterol in the adrenal cortex (glucocorticoids, mineralocorticoids, and adrenal androgens), the testes (testicular androgens, estrogen), and the ovary and placenta (estrogen and progestogen or progestins) (Payne AH & Hales DB 2004; Hu J et al. 2010;). SHs reach their target cells via the blood, where they are bound to specific carrier proteins (Grishkovskaya I et al. 2000; Hammond GL 2016). SHs detach from the carrier proteins and because of their lipophilic nature readily diffuse through the plasma membrane of cells (Oren I et al. 2004). Within the target cells SHs bind to steroid hormone receptors (SHRs) which are present in a heterocomplex with heat shock protein HSP90 and co-chaperones (e.g., immunophilins p23) (Echeverria PC & Picard D 2010). The ATP-bound form of HSP90 and chaperone-mediated conformational changes are required to keep SHRs in a ligand binding-competent state (McLaughlin SH et al. 2002; Pratt WB et al. 2008; Krukenberg KA et al. 2011).

Identifier: R-HSA-4341016
Species: Homo sapiens
Compartment: nucleoplasm
PIAS1 SUMOylates NR3C2 (Mineralcorticoid receptor, MR) at lysine-89, lysine-399, lysine-428, and lysine 494 with SUMO1 (Tallec et al. 2003, Tirard et al. 2007, Yokota et al. 2007). SUMOylation represses the transcription activation activity of NR3C2.

Complex (6 results from a total of 6)

Identifier: R-HSA-5618109
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8979216
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-4341117
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9725884
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-9725887
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-8948980
Species: Homo sapiens
Compartment: cytosol

Icon (1 results from a total of 1)

Species: Homo sapiens
Mineralocorticoid receptor
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