Search results for NR5A2

Showing 14 results out of 14

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Protein (6 results from a total of 6)

Identifier: R-HSA-9011735
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A2: O00482
Identifier: R-HSA-3008758
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A2: O00482-1
Identifier: R-HSA-3196162
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A2: O00482-3
Identifier: R-HSA-3196165
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A2: O00482-2
Identifier: R-HSA-4755447
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: NR5A2: O00482-2
Lysine-270 in the long isoform (isoform 2) corresponds to lysine-224 in the shorter isoform (isoform 1).
Identifier: R-HSA-4755424
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: P63165

DNA Sequence (1 results from a total of 1)

Identifier: R-HSA-9606084
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000116833

Reaction (3 results from a total of 3)

Identifier: R-HSA-4755494
Species: Homo sapiens
Compartment: nucleoplasm
PIAS1,2-1 SUMOylate NR5A2 (LRH-1) with SUMO1 at lysine-270 (lysine-224 in the shorter isoform) (Chalkiadaki and Talianidis 2005, Ogawa et al. 2009, Venteclef et al. 2010). SUMOylation is enhanced when NR5A2 is bound to ligand. SUMOylated NR5A2 acts as a transrepressor of genes involved in inflammation such as haptoglobin, SAA, and CRP.
Identifier: R-HSA-210773
Species: Homo sapiens
Compartment: nucleoplasm
The NR5A2 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NR5A2 transcription requires the activity of the PDX1 transcription factor. These events and interactions have not been studied in vivo in humans, but are inferred from corresponding ones worked out in the mouse and from in vitro studies of PDX1 protein binding to the Nr5A2 gene (Annicotte et al. 2003).
Identifier: R-HSA-9012000
Species: Homo sapiens
Compartment: nucleoplasm
GREB1 (growth regulation by estrogen in breast cancer 1) is an estrogen-responsive gene that contains three EREs located 1.6, 9.5 and 21.2 kb upstream of the transcriptional start site (Ghosh et al 2000; Lin et al, 2004; Rae et al, 2005; Deschenes et al, 2007; Sun et al, 2007). By ChIP, all three EREs are bound by ESR1 and the transcriptional co-activator NCOA3 (also known as SRC3). Although this binding occurs even in the absence of estradiol treatment, binding is enhanced after estrogen stimulation (Sun et al, 2007). Estrogen-dependent GREB1 expression also depends on removal of the repressive H3K9 methlyation mark by KDM4B (Kawazu et al, 2011; Gaughan et al, 2013). Estrogen stimulation increases the occupancy of RNA polymerase II at the GREB1 gene and may promote transcription through the formation of chromatin loops. Estrogen stimulation also increases the level of H4 acetylation at the promoter (Sun et al, 2007; Deschenes et al, 2007). In addition to ESR1 and NCOA3, Kruppel-like finger (KLF) protein ZNF217 has also been shown to bind to ESR1 and enhance recruitment to GREB1 EREs. ZNF217 overexpression is associated with anchorage independent growth in MCF7 cell lines (Nguyen et al, 2014). Although both NCOA3 and ZNF217 have been shown to interact with the GREB1 EREs, no study has examined co-occupancy of the GREB1 enhancer by these two regulators.

Complex (3 results from a total of 3)

Identifier: R-HSA-9011926
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-4755467
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-4755410
Species: Homo sapiens
Compartment: nucleoplasm

Icon (1 results from a total of 1)

Species: Homo sapiens
Curator: Bruce May
Designer: Cristoffer Sevilla
NR5A2-1 icon
Isoform of Nuclear Receptor subfamily 5 group A member 2
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