Search results for P00533

Showing 30 results out of 61

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Results (30 results from a total of 61)

EGFR

Identifier: R-HSA-179837
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR

Identifier: R-HSA-9611160
Species: Homo sapiens
Compartment: endosome membrane
Primary external reference: UniProt: EGFR: P00533

p-6Y-EGFR

Identifier: R-HSA-179803
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

p-Y1086,Y1101-EGFR

Identifier: R-HSA-179868
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR

Identifier: R-HSA-8864019
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

p-4Y-EGFR

Identifier: R-HSA-180287
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L747_S752del

Identifier: R-HSA-1228016
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR G598V

Identifier: R-HSA-1996314
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR T263P

Identifier: R-HSA-1996315
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR G719C

Identifier: R-HSA-1177531
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR E746_S752delinsV

Identifier: R-HSA-1228025
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR A289T

Identifier: R-HSA-1996306
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR G719A

Identifier: R-HSA-1177532
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR E746_T751delinsA

Identifier: R-HSA-1228031
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L747_A750delinsP

Identifier: R-HSA-1228034
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR R108K

Identifier: R-HSA-1996330
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L861Q

Identifier: R-HSA-1177542
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
L861Q, a substitution of leucine 861 with glutamine, is a documented EGFR mutation in the non-small-cell lung cancer (NSCLC). Leu861, encoded by exon 21, localizes to the N-terminal portion of the activation loop (A loop) of the kinase domain of EGFR and together with Leu858 participates in hydrophobic interactions that keep the kinase in the inactive conformation (Zhang et al. 2006). Replacement of Leu861 with glutamine is expected to destabilize the inactive conformation of EGFR and result in constitutive catalytic activity (Zhang et al. 2006). NSCLCs harboring L861Q mutation in EGFR are responsive to small EGFR-specific tyrosine kinase inhibitors from the 4-anilinoquinazoline group gefitinib (Lynch et al. 2004) and are expected to be responsive to the related drug, erlotinib.

EGFR A289D

Identifier: R-HSA-1996327
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L747_T751del

Identifier: R-HSA-1228015
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L747_T751delinsP

Identifier: R-HSA-1228012
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR A289V

Identifier: R-HSA-1996321
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L747_P753delinsS

Identifier: R-HSA-1228010
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR E746_A750del

Identifier: R-HSA-1181211
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR G719S

Identifier: R-HSA-1169418
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR L858R

Identifier: R-HSA-1173212
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
L858R, a substitution of leucine 858 with arginine, accounts for ~40% of EGFR mutations in the non-small-cell lung cancer. L858R, encoded by exon 21, localizes to the N-terminal portion of the activation loop (A loop) of the kinase domain of EGFR. By locking the EGFR in its active conformation, L858R mutation results in constitutive catalytic activity of EGFR which is ~50-fold higher than the activity of the wild-type enzyme (Yun et al. 2007). The L858R EGFR mutant is inhibited by binding of small EGFR-specific tyrosine kinase inhibitors from the 4-anilinoquinazoline group, erlotinib and gefitinib, as well as the pyrrolopyrimidine compound AEE788. Gefitinib is ~100-fold more potent against the L858R mutant than against the wild-type EGFR kinase (Yun et al. 2007). Erlotinib (Pao et al. 2004) and AEE788 (Yun et al. 2007) are also more efficient in inhibiting the L858R mutant than the wild-type EGFR.

EGFR N771_H773dup

Identifier: R-HSA-1996317
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR A767_V769dup

Identifier: R-HSA-1996326
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR K739_I744dup

Identifier: R-HSA-1996325
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR D770_N771insNPG

Identifier: R-HSA-1996322
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533

EGFR E746_A750del;T790M

Identifier: R-HSA-1181399
Species: Homo sapiens
Compartment: plasma membrane
Primary external reference: UniProt: EGFR: P00533
Secondary mutation T790M in EGFR E746_A750del mutant confers TKI resistance and results in cancer progression in patients initially responsive to TKI therapy (Balak et al. 2006).
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